320例急性脑血管疾病的危险因素及诱发因素分析

３２０例急性脑血管疾病的危险因素及诱发因素分析晋江市安海医院施群力，陈娜，杨玲对急性脑血管意外的发病危险因素及诱发因素已有诸多报道。由于地区不同，气候特点的差异，生活习惯不同，发病年龄分布，发病季节等也有所差异。本文对我院从１９８９年至１９９４年收治...     

ACUPUNCTURE AT JIANJING FOR TREATMENT OF ACHALASIA OF THE CARDIA

Achalasia of the cardia,also known ascardiospasm or megalo—esophagus,Is char-acterized by the symptom of dysphagia.Diagnosis of the disease and its division intodifferent types are described in the PracticalTextbook of Medicine and Symposium onMedicine.During the recent 10 years,theauthor treated 21 cases of the disease byacupuncture with satisfactory results as re-ported in the following.     

环丙沙星注射液引起过敏反应2例

环丙沙星注射液引起过敏反应２例施志刚刘萍杨（河北医科大学第三医院０５００５１）梁灵芝乔久玉（石家庄市友谊医院）环丙沙星属于喹诺酮类药物，是新一代合成的广谱抗菌药。该药抗菌谱广、杀菌作用强、毒副作用小因此广泛应用于临床。但近一个月来使用该药发生２例过敏...     

嘉兴外来人员生活环境与肠道传染病相关知信行现况调查分析

目的了解城郊结合部外来人员聚集地生活环境现况和霍乱等肠道传染病健康知信行情况,进一步明确肠道传染病防治健康教育与健康促进工作的重点开展方向。方法采用随机抽样的方法,运用统一设计的调查问卷对嘉兴市5县2区城郊结合部等外来人员聚集地进行流行病学调查。结果93.06%的调查对象以租房为主,90.61%的生活用水来源于自来水,9.25%用井水;78.61%的人知道霍乱传播途径,21.53%的人知道霍乱主要临床症状,28.03%的人知道肠道传染病全部预防措施;77.31%的知识来源于电视,其他顺位依次为书刊、广播、家人或朋友处;希望获得宣传资料形式:传单占46.68%,墙报占31.21%。结论外来人员租房人数居多,有部分人使用井水;肠道传染病相关知识了解的较少。应采取多部门齐抓共管来改善外来人员聚集地的生活环境,因地制宜地对外来人员开展有针对性的预防肠道传染病健康教育。     

大肠癌手术后肝转移的诊断与治疗

目的：探讨大肠癌手术后肝转移的诊断与治疗。方法：对35例大肠癌手术后肝转移的诊治效果进行回顾性分析。结果：所有的病例均得到CEA、B超和（或）CT检查证实，其1年和3年生存率在根治性手术切除组明显高于其他治疗组。结论：肝转移癌的早期诊断是提高生存率的关键，手术切除及选择性肝动脉栓塞化疗是改善其预后的选择。     

吗啡预处理-后处理对大鼠离体心脏缺血再灌注损伤的影响

Objective To evaluate the effects of morphine preconditioning-postconditioning on ischemia-reperfusion (I/R) injury in isolated rat hearts. Methods Male SD rats weighing 180-200 g were killed after intraperitoneal injection of heparin 500 U/kg. The hearts were immediately removed and perfused in a Langendorff apparatus with K-H solution gassed with 95%O2-5%CO2 .HR and left ventricular systolic pressure (LVSP) were measured from a fluid-filled latex balloon in the left ventricle. Global myocardial ischemia was induced by interrupting perfusion for 45 min followed by 60 min reperfusion. Forty isolated rat hearts were randomly divided into 5 groups (n = 8 each): group 1 (I/R); group II morphine preconditioning (M1 ); group Ⅲ morphine postconditioning (M2); group IV M1 + M2; group V 5-hydroxydecanoate (5-HD) + M2. Group M1 was perfused with K-H solution containing morphine 3.0 μmol/L for 20 min 30 min before ischemia followed by 10 min normal K-H solution perfusion. Group M2 was perfused with K-H solution containing morphine 3.0 μmol/L for 10 min at the beginning of reperfusion followed by 50 min normal K-H solution perfusion. Group 5-HD + M2 was perfused with K-H solution containing morphine 3.0 μmol/L+ 5-HD 10-4 mmol/L for 10 min at the beginning of reperfusion followed by 50 min normal K-H solution perfusion. Myocardial CK-MB activity was measured and myocardial infarct size (IS/AAR) detennined (by 2,3,5-triphenyl tetrazolium staining) at the end of 60 min reperfusion. Results The preconditioning, postconditioning and combination of preconditioning and postconditioning with morphine 3.0 μmol/L perfusion for 10 min all provided cardio-protective effects in terms of IS/AAR and myocardial activation of CK-MB. Conclusion Although the combination of morphine preconditioning and postconditioning can protect the heart against I/R injury, the effects are similar to those of either of them alone, and the reason may be that either of them alone protects the heart against I/R injury via activating mitoKATP .     

中国人中所见黑蒙性痴呆的新突变

在３个中国婴儿型黑蒙性痴呆（Ｔａｙ－Ｓａｃｈｓｄｉｓｅａｓｅ，ＴＳＤ）家庭中鉴定了３种突变等位基因，这３家无血缘关系，也无亲近婚配。其中两种突变等位基因是新的，第三种则为曾报道过的突变（Ｇ１４４４Ａ）。家庭１，ＤＮＡ经ＰＣＲ体外扩增后直接测序，发现为ＨＥＸＡ基因第５外显子的第５４７核苷酸处插入一个腺嘌呤所造成的移码突变，导致插入部位下游６ｂＰ处提前出现终止密码。用等位基因特异性寡核苷酸（ＡＳＯ）杂交证明先证者为突变基因纯合子。家庭２，用单链构象多态性（ＳＳＣＰ）分析及将扩增的第１３外显子直接测序，发现为第１４５３核苷酸Ｔ转换为Ｃ，造成第４８５位色氨酸为精氨酸取代，以Ｔ１４５３Ｃ（ｅｘｃｏｎ１３）／Ｗ４８５Ｒ表示之（Ｗ代表色氨酸，Ｒ代表精氨酸）。此突变造成了一个Ｆｎｕ４Ｈ１酶切位点。患儿则为此等位基因的纯合子。当Ｔ１４５３Ｃ定向致突变的αｃＤＮＡ在ＣＯＳ－１细胞中表达时，未能测出氨基已糖苷酶（Ｈｅｘ）Ｓ的活性。家庭３的突变为第１３外显子的１４４４核苷酸Ｇ转换为Ａ，造成第４８２位谷氨酸为赖氨酸取代，以Ｇ１４４４Ａ（ｅｘｏｎｌ３）／Ｅ４８２Ｋ表示之（Ｅ代表谷氨酸，Ｋ代表赖氨酸）。此突变发生于一个ＧｐＧ二核苷酸，以     

一种新的复方制剂对胃溃疡疗效的统计分析

研制一种新用复方制剂,用于治疗胃溃疡。为了解其是否确有治疗效果,用大鼠结扎胃溃疡模型作实验,对所得的数据资料进行了统计分析。