一期根治术治疗婴儿肛周脓肿47例

2008～2011年，我们采用一期根治术治疗婴儿肛周脓肿47例，取得满意疗效，现报告如下。 临床资料：本组患儿男46例，女1例；年龄7d至12个月，平均1～3个月；发病时间平均2～5d。脓肿位于截石位3点位19例，9点位27例。     

玻璃纤维桩并树脂修复上前牙冠折伴安氏Ⅱ类错殆临床观察

目的:针对安氏Ⅱ类深覆骀青少年上颌前牙冠折患者,使用玻璃纤维桩并树脂修复体进行早期修复和正畸治疗,观察其疗效.方法:患者35例,患牙37颗,以玻璃纤维桩并复合树脂修复,其中30例患者接受了正畸治疗.结果:本研究中所修复的37颗牙,在2年随访中,修复体均无脱落折断.结论:采用玻璃纤维桩并复合树脂修复安氏Ⅱ类错胎深覆骀青少年前牙冠折,可获得良好的固位及美观效果,并为正畸治疗及成年后永久修复治疗创造条件.     

甲氨基阿维菌素的致突变性、致畸性及亚慢性毒性的研究

目的与方法:本文报道了甲氨基阿维菌素小鼠骨髓嗜多染红细胞微核试验,小鼠精子畸形试验,Ames 试验,对大鼠的亚慢性毒性试验及致畸试验的研究结果。结果与结论:其剂量在6. 3～25. 2mg/ kg 的微核试验结果表明,各剂量组与阴性对照组的微核率比较,结果无显著意义( P > 0105) 。10～500μg/ 皿剂量组Ames 试验及15. 8～63mg/ kg. bw 剂量组小鼠精子畸形试验结果均为阴性。致畸研究结果表明,该药对大鼠无明显母体毒作用和胚胎毒作用。亚慢性毒性试验中,高剂量组雌性大鼠(9. 26mg/ kg. bw) 尿素氮、雄性大鼠(12. 6mg/ kg. bw) 尿素氮及白蛋白水平有一定程度的改变,雄、雌性大鼠肾脏脏器系数有显著的改变( P < 0105) 。雄性大鼠(12. 6mg/ kg. bw) 体重明显降低( P < 0105) ,比雌性大鼠影响略大。亚慢性毒性最大耐受剂量雌性大鼠为1. 16mg/ kg. bw ,雄性大鼠为1. 57mg/ kg. bw。     

细支气管肺泡癌的FDG-PET影像特点

目的研究细支气管肺泡癌对~(18)氟脱氧葡萄糖(FDG)的摄取特点。方法 1998年12月～2004年10月间,35例细支气管肺泡癌患者术前行FDG-正电子发射体层显像(PET)检查。PET结果用目测法与半定量分析方法判读。半定量分析方法中计算标准摄取值(SUV)。结果所有肿瘤都被FDG-PET探测到,目测法相应部位FDG不同程度浓聚。半定量分析细支气管肺泡癌组织的FDG摄取(SUVmax and SUVmean)高于相应的正常肺组织(SUVlung)(P＜0.001),SUVmax、SUVmean和SUVlung分别为3.14±1.65、2.40±1.34 和0.38±0.08。细支气管肺泡癌SUV与肿瘤大小正相关(P＜0.05)。21例(21／35,60.0％)SUVmean与15例(15／35,42.9％)SU Vmax低于2.5。这21例肿瘤全部被目测法与半定量分析判断为良性。结论 (1)细支气管肺泡癌组织的FDG摄取高于正常肺组织。(2)肿瘤FDG摄取与肿瘤大小有关。(3)很多细支气管肺泡癌病例 FDG-PET检查可呈现假阴性。     

有机磷酸酯引起的迟发性神经病的“强化”机理

某些酯酶抑制剂可以强化创伤和中毒引起的轴突病 ,这可以从临床症状和组织病理学上加以证实。有机磷酸酯诱导的迟发性神经病是研究轴突病强化机制的良好模型 ,有机磷酸酯诱导的迟发性神经病的强化可能与神经系统的修复机理有关。强化剂的靶标位点还未清楚 ,但不是神经病靶标酯酶 ,而可能与一种类似于神经病靶标酯酶的特殊酯酶有关     

浆膜受侵的结直肠癌术后腹腔化疗联合静脉化疗的临床研究

Objective To compare the clinical efficacy of postoperative intraperitoneal chemotherapy combined with systemic chemotherapy to systemic chemotherapy alone for serosa-involved colorectal cancer. Methods According to the criteria of serosa-involving in colorectal cancer, 332 cases were divided into 2 groups prospectively without randomization. Study group (n=166) was treated with intraperitoneal chemotherapy combined with systemic chemotherapy, and control group (n=166) with systemic chemotherapy alone. Incidence of local recurrence, peritoneal metastasis, hepatic metastasis, other distant metastasis and 3-year, 5-year overall survival (OS) rate of two groups were compared. Results 3-year and 5-year OS rates of stage Ⅱ B in study group were similar to those in control group (χ2=0.612,P=0.434). The above rates of stage Ⅲ in study group were higher than those in control group (χ2=3.989,P=0.046). Either the study group or the control group, the 3-year and 5-year OS rates of patients undergone laparoscopic surgery or open surgery were similar (P=0.839, P=0.172). Incidences of local recurrence, peritoneal metastasis and hepatic metastasis in study group were 1.9%, 3.8% and 3.8% respetively, lower than those in control group (8.2%,9.5% and 10.1%,P<0.05). Distant metastasis rate in study group was similar to that in control group. In study group, intraperitoneal chemotherapy regimen with Oxaliplatin had lower rates of peritoneal metastasis and hepatic metastasis as compared to that with Cisplatin (0.9% vs 8.8% ,P=0.019), while the incidences of local recurrence and other distant metastasis were similar. Conclusions Postoperative intraperitoneal chemotherapy combined with systemic chemotherapy improves 3-year and 5-year overall survival rates in patients with stage Ⅲ serosa-involved colorectal cancer, and decreases local recurrence, peritoneal metastasis and liver metastasis rate, especially when intraperitoneal chemotherapy regimen contains Oxaliphtin. Comparing with open surgery, laparoscopic surgery dose not improve 3-year and S-year overall survival rates in patients receiving combined chemotherapy or systemic chemotherapy alone.     

长期误诊为周期性麻痹的干燥综合征并肾小管酸中毒1例报告

患者,女,32岁。1976年因四肢无力低血钾而诊为“周期性麻痹”,此后有类似发作。1980年因眼干诊为“角膜炎”,并反复皮肤紫瘢。1985年分娩后出现口干无力多饮多尿,关节肿痛及肝功异常。因再次四肢软瘫、呼吸困难,经当地医院补钾治疗后于1987年5月11日入我院。体检:血压110/80,心、肺、肝、脾未见异常,肾区无叩痛、双下肢点片状紫瘢,左手指