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排序方式: 共有1507条查询结果,搜索用时 31 毫秒
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2.
Kiyoshi Uchide Hirohisa Ueno Noboru Takizawa Yasunori Okada 《Journal of bone and mineral research》2003,18(2):381-382
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) were measured in a mild case of dyssegmental dysplasia. X-ray pictures of a female baby born vaginally at 39 weeks of gestation showed short, bent, dumbbell-shaped long bones of the limbs and profound dyssegmental ossification in the spine, findings characteristic of dyssegmental dysplasia. When the levels of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were measured, the levels of MMP-2 and TIMP-1 were significantly reduced. This case might provide a clue to disclose the etiology of dyssegmental dysplasia. 相似文献
3.
Satoshi Yoneda Yozo Kobayashi Takehiro Nunoi Kosuke Takeda Atsushi Matsumori Minoru Andoh Hirohisa Tsujinoue Kimio Nishimura Hiroshi Fukui 《Nihon Shokakibyo Gakkai zasshi》2006,103(11):1270-1273
A 23-year-old woman had lower abdominal pain, diarrhea and bloody stool was admitted and given a diagnosis of influenza B. Her home doctor had started treatment by neuraminidase inhibitor (oseltamivir) the previous day. Colonoscopic examination revealed an area of hemorrhage and erosion in the left transverse colon. After halting oseltamivir treatment these symptoms disappeared and her colonoscopic findings improved. A drug-induced lymphocyte stimulation test was positive for oseltamivir. This case is the first reported case of acute hemorrhagic colitis induced by oseltamivir. 相似文献
4.
Jun Maeda Mitsunori Ohta Hirohisa Hirabayashi Hikaru Matsuda 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2005,53(4):196-198
We present a case of lung cancer that showed false positive accumulation in an 18F fluorodeoxyglucose positron emission tomography (FDG-PET) scan following induction chemotherapy for suspected metastasis
and progression of malignancy. A 66-year-old man was diagnosed with squamous cell carcinoma in the lung, classified as clinical
stage IIIA (T2N2M0), and underwent induction chemotherapy. An FDG-PET scan prior to chemotherapy demonstrated accumulation
only in the tumor, whereas following treatment it revealed a strong accumulation not only in the tumor, but also in the supraclavicular
lymph nodes, which indicated lymph node metastasis. The patient underwent a biopsy of the right supraclavicular lymph node
and mediastinoscopy, after which all dissected lymph nodes showed sarcoid reactions and no tumor cells were found pathologically.
We concluded that when evaluating the effect of induction chemotherapy for malignancy, a sarcoid reaction might lead to the
false positive accumulation of FDG. 相似文献
5.
Yasushi Sano Hirohisa Machida Kuang‐I. Fu Hiroaki Ito Takahiro Fujii 《Digestive endoscopy》2004,16(Z1):S93-S96
The goal of endoscopic mucosal resection (EMR) is to allow the endoscopist to obtain tissue or resect lesions not previously amenable to standard biopsy or excisional techniques and to remove malignant lesions without open surgery. In this article, we describe the results of conventional EMR and EMR using an insulation‐tipped (IT) electrosurgical knife (submucosal dissection method) for large colorectal mucosal neoplasms and discuss the problems and future prospects of these procedures. At present, conventional EMR is much more feasible than EMR using IT‐knife from the perspectives of time, money, complication, and organ preservation. However, larger lesions tend to be resected in a piecemeal fashion; and it is difficult to confirm whether EMR has been complete. For accurate histopathological assessment of the resected specimen en bloc EMR is desirable although further experience is needed to establish its safety and efficacy. Further improvements of in EMR with special knife techniques are required to simply and safely remove large colorectal neoplasms. 相似文献
6.
Hirohisa Miyake Patrick O. Eghwrudjakpor Takashi Sakamoto Koreaki Mori 《Child's nervous system》1992,8(5):243-246
Experimental hydrocephalus was induced in rats by intracisternal injection of kaolin suspension. The amounts of norepinephrine and dopamine were determined in the whole brain and specific brain regions at 1 week (acute phase) and 4 weeks (chronic phase). The turnover of catecholamine, an index of the activity of catecholamine-containing neurons, was determined by measuring the decrease in catechlamine contents 2 h after intraperitoneal injection of -methyl-p-tyrosine (250 mg/kg), an inhibitor of tyrosine hydroxylase. We observed that the catecholamine contents in kaolin-induced hydrocephalus were not significantly different from control values. Following injection of -methyl-p-tyrosine, there was decrease in levels of catecholamines in both control and hydrocephalic rats. This decrease was, however, significantly less in induced hydrocephalus than in control animals. This result suggested that in hydrocephalus, the activities of norepinephrinergic and dopaminergic neurons are reduced. 相似文献
7.
Hery?Wijayanto Yuriko?Hirai Yosirou?Kamanaka Akira?Katho Dondin?Sajuthi Hirohisa?HiraiEmail author 《Chromosome research》2005,13(7):715-722
The course of chromosome evolution in small apes is still not clear, though painting analyses have opened the way for elucidating
the puzzle. Even the C-banding pattern of the lar-group of gibbons (the genus Hylobates) is not clarified yet, although our previous studies suggested that lar-group gibbons have a unique C-banding pattern. We
therefore made observations to establish C-banded karyotypes of the agile gibbons included in the lar-group. The data were
compared with those of siamangs (the genus Symphalangus), which carry distinctive C-bands, to determine the chromosomal patterns in each group. C-banded chromosomes of agile gibbons
showed several terminal, interstitial and paracentric bands, whose patterns are specific for each chromosome, whereas the
C-bands of siamangs were located only at the terminal and centromeric regions in most chromosomes. Moreover, the C-bands of
agile gibbons and siamangs were shown to be G+C-rich and A+T-rich DNA, respectively, by DAPI/C-band sequential staining. Additionally,
PRINS labelling with a telomere primer revealed that agile gibbons have telomeric DNA only at chromosome ends where there
is no C-band (non-telomeric heterochromatin), whereas the telomeric DNA of siamangs is located in the terminal C-banded regions
(telomeric heterochromatin). Although the evolutionary mechanisms in small apes are still unknown, C-banding patterns and
distribution of telomeric DNA sequences should provide valuable data to deduce the evolutionary pathways of small apes. 相似文献
8.
9.
Spök A Gaugitsch H Laffer S Pauli G Saito H Sampson H Sibanda E Thomas W van Hage M Valenta R 《International archives of allergy and immunology》2005,137(2):167-180
The prevalence of allergic diseases has been increasing continuously and, accordingly, there is a great desire to evaluate the allergenic potential of components in our daily environment (e.g., food). Although there is almost no scientific evidence that genetically modified organisms (GMOs) exhibit increased allergenicity compared with the corresponding wild type significant concerns have been raised regarding this matter. In principle, it is possible that the allergenic potential of GMOs may be increased due to the introduction of potential foreign allergens, to potentially upregulated expression of allergenic components caused by the modification of the wild type organism or to different means of exposure. According to the current practice, the proteins to be introduced into a GMO are evaluated for their physiochemical properties, sequence homology with known allergens and occasionally regarding their allergenic activity. We discuss why these current rules and procedures cannot predict or exclude the allergenicity of a given GMO with certainty. As an alternative we suggest to improve the current evaluation by an experimental comparison of the wild-type organism with the whole GMO regarding their potential to elicit reactions in allergic individuals and to induce de novo sensitizations. We also recommend that the suggested assessment procedures be equally applied to GMOs as well as to natural cultivars in order to establish effective measures for allergy prevention. 相似文献
10.
Atsushi Ohashi PhD Hirohisa Kotera BS Hideo Hori BS Makoto Hibiya PhD Koji Watanabe MD PhD Kazutaka Murakami MD PhD Midori Hasegawa MD PhD Makoto Tomita MD PhD Yoshinobu Hiki MD PhD Satoshi Sugiyama MD PhD 《Journal of artificial organs》2005,8(4):252-256
Polyvinyl chloride (PVC) tubing is an indispensable medical material for extracorporeal circulation therapy. However, di(2-ethylhexyl)phthalate
(DEHP), a suspected endocrine disruptor, can be eluted from PVC, suggesting that an alternative material that does not contain
DEHP is needed for clinical applications. First, we evaluated the endocrine disrupting risks of the plasticizers contained
in PVC tubes by investigating their binding affinities for the human estrogen receptor alpha (ERα). Our results revealed that,
while DEHP has some binding affinity for ERα, neither epoxidized soybean oil nor tris(2-ethylhexyl)trimellitate (an alternative
to DEHP) has any affinity for ERα. Second, we evaluated the endocrine disrupting risks of a tube made of newly developed plasticizer-free
(PF) materials. We confirmed the presence of DEHP and detected several unidentified substances in plasma stored within the
PVC tube. This plasma's competitive binding affinity for ERα was significantly higher than that of control plasma (P < 0.01). In contrast, the profile of plasma stored in the PF tube was similar to that of the control, both in terms of high-performance
liquid chromatography chromatograms and competitive binding capacity for ERα, suggesting that the PF tube is biocompatible
and is useful for reducing the elution of substances capable of binding to ERα.
Presented in part at the 42nd Congress of the Japanese Society for Artificial Organs, October 5–7, 2004, Tokyo, Japan 相似文献