Clinical evaluation of ceramic inlay made by CAD/CAM for 3 year]

In this study,ceramic inlays made by CAD/CAM system were used to restore posterior tooth defects.After three years of clinical observation on 21 prostheses no secondary caries was found and patients satisfied with their restoration on aspects of color match and resistance to wear etc.Five cases of inlay fracture and of obvious space between inlay margin and Cavowall were found.The main reason was the insufficient thickness of the inlays meanwhile the selection of bonding agent was not appropriate.The clinical successful rate is 76.20%.As CAD/CAM is a sophisticated technique induced into prosthodontic area just in 1980's,it has still some deficiency to be improved and perfected.     

下颌骨骨折动力加压固定断面应力分析

实验采用反射光弹模拟应力分析法,通过受力模型等差线条纹图观测、分析、量化换算,对下颌骨骨折轴向和偏心动力加压固定作断面压应力比较研究.结果显示两种固定状态下骨折断面均表现为挤压应力,沿骨折线应力分布不均匀,板周区和牙槽区呈压应力高峰带,最大应力分量在轴向和偏心加压分别为1.8MPa和2.3MPa(板周区),以及0.5MPa和1.0MPa(牙槽区),中间区受力较弱.轴向动力加压总压力为100N,偏心动力加压总压力为140N,后者比前者断面应力分布稍趋合理.     

异种烧结骨修复颌骨缺损的临床观察

本文报告了应用异种烧结骨修复颌骨缺损25例,采用手术前后X线及免疫学、r骨显像等观察,进行了较系统的临床研究.经6～12个月追踪观察,结果表明:创口愈合正常,未见免疫排斥反应.术后3周左右植骨成活,2～3个月有新骨形成、与空白对照组比较,烧结骨有明显加快骨缺损部位成骨作用,新生骨出现早,成骨速度快.证实烧结骨具有良好的组织相容性和骨传导能力,具有较高的临床实用性,是一种较理想的骨移植材料.     

吸烟与牙周病关系的研究

为研究吸烟与牙周病的关系，调查４３２名中老年男性的口腔卫生状况、牙周状况及吸烟习惯。结果表明吸烟者软垢指数与不吸烟者相同，龈炎区段数两者差异无显著性，吸烟者牙周炎区段数高于不吸烟者。重度吸烟者牙周炎区段数高于轻、中度吸烟者及不吸烟者。调查结果提示吸烟可能是牙周病流行的高危因素之一。     

Genome-wide association scan for childhood caries implicates novel genes

Dental caries is the most common chronic disease in children and a major public health concern due to its increasing incidence, serious health and social co-morbidities, and socio-demographic disparities in disease burden. We performed the first genome-wide association scan for dental caries to identify associated genetic loci and nominate candidate genes affecting tooth decay in 1305 US children ages 3-12 yrs. Affection status was defined as 1 or more primary teeth with evidence of decay based on intra-oral examination. No associations met strict criteria for genome-wide significance (p < 10E-7); however, several loci (ACTN2, MTR, and EDARADD, MPPED2, and LPO) with plausible biological roles in dental caries exhibited suggestive evidence for association. Analyses stratified by home fluoride level yielded additional suggestive loci, including TFIP11 in the low-fluoride group, and EPHA7 and ZMPSTE24 in the sufficient-fluoride group. Suggestive loci were tested but not significantly replicated in an independent sample (N = 1695, ages 2-7 yrs) after adjustment for multiple comparisons. This study reinforces the complexity of dental caries, suggesting that numerous loci, mostly having small effects, are involved in cariogenesis. Verification/replication of suggestive loci may highlight biological mechanisms and/or pathways leading to a fuller understanding of the genetic risks for dental caries.     

Parry-Romberg syndrome combined with hemifacial spasm: association or chance event?

Parry-Romberg syndrome or progressive facial hemiatrophy is a rare clinical entity of an unknown etiology. We present the case of a 57-year-old Chinese woman with Parry-Romberg syndrome and hemifacial spasm both on the right side. Its association was not reported before. In our report of Parry-Romberg syndrome with hemifacial spasm, we try to explore whether there were some relations between the 2 diseases. We found an offending vessel compressing the root exit zone of the facial nerve and no evidence of vessel compression at ipsilateral trigeminal nerve motor rootlet.     

Role of calcium and PKC in salivary mucous cell exocrine secretion

Fluid and exocrine secretion of mucins by salivary mucous glands is regulated predominantly by parasympathetic activation of muscarinic receptors. A direct role for subsequent putative signaling steps, phospholipase C (PLC), increased intracellular calcium ([Ca(2+)](i)), and isoforms of protein kinase C (PKC) in mediating muscarinic exocrine secretion has not been elucidated, and these are potential therapeutic targets to enhance mucin secretion in hyposalivary patients. We found that muscarinic-induced mucin secretion by rat sublingual tubulo-acini was dependent upon PLC activation and the subsequent increase in [Ca(2+)](i), and further identified a transient PKC-independent component of secretion dependent upon Ca(2+) release from intracellular stores, whereas sustained secretion required entry of extracellular Ca(2+). Interactions among carbachol, PKC inhibitors, phorbol 12-myristate 13-acetate, and thapsigargin to modulate [Ca(2+)](i) implicated conventional PKC isoforms in mediating sustained secretion. With increasing times during carbachol perfusion of glands, in situ, PKC-α redistributed across glandular membrane compartments and underwent a rapid and persistent accumulation near the luminal borders of mucous cells. PKC-β1 displayed transient localization near luminal borders, whereas the novel PKCs, PKC-δ or PKC-ε, displayed little or no redistribution in mucous cells. Collective results implicate synergistic interactions between diacylglycerol (DAG) and increasing [Ca(2+)](i) levels to activate cPKCs in mediating sustained muscarinic-induced secretion.     

Efficacy of A-dec's ICX dental unit waterline treatment solution in the prevention and treatment of microbial contamination in dental units

OBJECTIVE: Even though some chemical agents can disinfect biofilms in dental unit waterlines, there remains concern that all remnants of the biofilm matrix are not eliminated. Even with periodic treatments, the bacterial populations in dental unit waterlines recur rapidly. In addition, with some previously tested products, patient safety, as well as toxic, caustic and corrosive residual chemicals are also a concern. This study evaluated ICX, A-dec's new water treatment solution, in a series of experiments for prevention, microbial spectrum of activity, minimum inhibitory time determination, and treatment of established biofilms. METHODOLOGY: New dental unit waterline tubing was treated continuously during simulated patient care over 28 days with municipal water. It was then treated with ICX. Effluents from lines with established biofilms (averaging > 10(4) CFU/ml at day 0) were treated to assess levels of CFU counts within 21 days of exposure to ICX. RESULTS: Tubing treated with ICX did not develop a detectable biofilm using ruthenium red staining, and microbes in effluents remained undetectable. CONCLUSION: ICX is effective in maintaining the effluent within the American Dental Association's and the Centers for Disease Control's recommendation for < 500 CFU/ml. In addition, considering the preliminary finding that ICX reduces microbial contamination of effluents from established biofilm lines, it may be useful in long-term treatment alone or when coupled with a shock treatment to assist in biofilm destruction.