Mandibular distraction osteogenesis reconstructed the upper airway in a case of Melnick�CNeedles syndrome

Introduction

We report a 16-year-old female with Melnick?CNeedles syndrome complicated with severe obstructive sleep apnea?Chypoxia syndrome.

Clinical report

An overnight sleep study demonstrated that the patient had severe obstructive sleep apnea with an apnea?Chypopnea index of 95/h. The lowest oxygen saturation was only 34%. The distraction osteogenesis technique was used to lengthen her mandible for the reconstruction of her upper airway.

Result and Discussion

Postoperative panorex showed that the bilateral body of her mandible had been distracted about 16?mm singulorumly in the end of our distraction. Lateral radiograph revealed that the diameter of oral pharynx widen nearly 5?mm. The patient recovered after the upper airway reconstruction.     

静态拉伸应变对人牙周膜成纤维细胞的影响

目的：研究人牙周膜成纤维细胞(PDLF)在机械拉伸应变作用下，细胞和细胞核投影面积及其细胞骨架的改变情况，探讨PDLF的形态、功能和应变之间的关系。方法：采用自制的细胞体外静态机械加载装置用不同的拉伸应变量加力于细胞上，通过激光扫描共聚焦显微镜观察细胞骨架的形态及其改变情况，并进行统计分析。结果：在8％、12％、16％力值组，细胞和细胞核投影面积随着加力时间和力值的增加而每天递增，肌动蛋白纤维也随之逐渐增粗，排列更有规律；而在20％力值组，其结果则反之。结论：静态拉伸应变可影响牙周膜成纤维细胞的骨架。     

上颌尖牙唇向错位34例临床矫治

为了对上颌尖牙唇向错位进行正确的矫治设计,作者根据错位的病因、X线头影测量结果,对34例上颌尖牙唇向错位病例,分别采用前牙片段方丝辅弓法,改良Richett's弓法,推磨牙向后法,拔除第2乳磨牙法,拔除第一双尖牙法,取得满意结果。作者认为在矫治上颌尖牙唇向错位时,应充分利用潜在间隙,根据X线头影测量结果及错位形成原因进行综合分析,选用最佳方法进行矫治。     

MRI在口腔颌面部肿块诊断中的应用

作者对38例发生在口腔颌面部肿块患者采用MRI检诊。结合缅针穿吸缅胞学检查，并与CT扫描对比研究。结果提示：对口腔颌面部肿块。管状瘤或临床怀疑肿瘤有颅底、眶尖、翼腭窝、咽侧、颈部大血管神经累及者。MRI扫描成像清晰。软组织分辨率高。能早期发现骨质侵蚀。作者还对MRI在监测颌面部癌瘤切除术后局部是否复发进行初步观察。     

Surgery of juvenile periodontitis]

The clinical efficiency of surgery for juvenile periodontitis (JP) followed-up for 13.5 (6-21) months was evaluated in this paper. A total of 102 teeth in 43 patients were included in the study, of them, three-wall infrabony pocket was in 74 teeth, two-wall infrabony pocket was in 21 teeth, one-wall infrabony pocket was in 7 teeth. After scaling, root planning and flap procedure, the rate of clinical efficiency was 74.51%, of which, three-wall infrabony pocket was 85.14%, two-wall infrabony pocket was 52.38%, one-wall infrabony pocket was 28.57%. The results show that if teeth with JP were effectively treated in time, better clinical efficiency can be obtained likewise, and if sectional osseous defects were properly treated, osseous restoration still is possible.     

Novel identification of a four-base-pair deletion mutation in PITX2 in a Rieger syndrome family

Rieger syndrome is one of the most serious causes of tooth agenesis. Mutations in the PITX2, FOXC1, and PAX6 genes have been associated with Rieger syndrome. We have studied a three-generation Chinese family affected with Rieger syndrome and showing prominent dental abnormalities. Mutational screening and sequence analysis of the PITX2 gene revealed a previously unidentified four-base-pair deletion of nucleotides 717-720 in exon 5 in all affected members. The mutation causes a frame shift after Thr44, the 7th amino acid of the homeo-domain, and introduces a premature stop codon in the gene sequence. This deletion is the first unquestionable loss-of-function mutation, deleting all the functionally important parts of the protein. Our novel discovery indicates that the oligodontia and other phenotypes of Rieger syndrome observed in this family are due to this PITX2 mutation, and these data further support the critical role of PIXT2 in tooth morphogenesis.     

1,25（OH）2维生素D3诱导小鼠混合培养细胞白细胞介素1αmRNA …

本研究旨在探讨破骨细胞形成过程中１，２５（ＯＨ）２维生素Ｄ３「１，２５（ＯＨ）２Ｄ３」和白细胞介素１α两种生物因子间的相互作用关系，以期进一步了解正畸牙齿移动过程中牙周组织改建的生物学机理。     

Quantitatively study of voice onset time-Glottal stop]

To quantitatively evaluate the acoustic characteristics of glottal stop, pronunciation of/ka/in 10 normal subjects and 14 patients with cleft palates were analyzed by sound spectrography and 20 msec in all normal articulation of /ka/ with an average time of 44.6 msec.In the test group of /ka/ demonstrated an average time of 20.8 msec.The inverse correlation ship between VOT and the psyco-acoustical judgment for the degree of distortion was demonstrated to be significant.     

镧、铈、氟在抑制人离体牙根面脱矿中作用的比较研究

作者采用含镧(La)、铈(Ce)、氟(F)的脱矿液，在体外模拟口腔pH循环变化的环境中对离体人牙根面进行抑制脱钙的实验研究，并采用化学及能谱分析手段，对La，Ce，F在根面的抑制脱钙作用进行定量分析。结果显示，这三种微量元素对根面均有明显的抑制脱钙作用，但F较La、Ce的抑制作用强．该研究还从晶体物理化学角度对La、Ce、F的抑制脱矿作用的机理进行探讨。     

The value of the different radiological examining methods in caries diagnosis]

This in vitro study compared the results of clinical examination (abbreviation CE) and the three radiological methods (i.e RVG-radiovisiography) on occlusal and proximal caries diagnosis,using pathological observation as the final standard.The results are:on occlusal caries diagnosis,CE provide the most accordant result to the pathological result.There are statistically significant differences between SR and CE,BW and CE.1st suggests that to occlusal caries diagnosis,CE is still a convenient and efficient way.On proximal caries diagnosis,there are statistically significant differences between SR and CE,BW and CE.BW has the most coincident result with pathological one.