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51.
Michael Marks Pere Millat-Martinez Dan Ouchi Chrissy h Roberts Andrea Alemany Marc Corbacho-Monné Maria Ubals Aurelio Tobias Cristian Tebé Ester Ballana Quique Bassat Bàrbara Baro Martí Vall-Mayans Camila G-Beiras Nuria Prat Jordi Ara Bonaventura Clotet Oriol Mitjà 《The Lancet infectious diseases》2021,21(5):629-636
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Yoshiaki?AbeEmail authorView authors OrcID profile Kentaro?Narita Hiroki?Kobayashi Akihiro?Kitadate Masami?Takeuchi Yoichi?Kikuchi Toshihiro?Ouchi Kengo?Takeuchi Kosei?Matsue 《Annals of hematology》2018,97(12):2345-2352
To investigate the prevalence and clinical value of abnormal findings detected via brain magnetic resonance imaging (MRI) in patients with intravascular large B-cell lymphoma (IVLBCL), we identified 33 patients with IVLBCL pathologically diagnosed and evaluated with pretreatment brain MRI. Abnormal findings on brain MRI were categorized into four patterns: (1) hyperintense lesion in the pons on T2-weighted imaging (T2WI), (2) nonspecific white matter lesions, (3) infarct-like lesions, and (4) meningeal thickening and/or enhancement. Abnormal cerebral findings were detected in 29 patients (87.9%). Hyperintense lesion in the pons was the most common finding (n?=?19 (57.6%) patients), followed by nonspecific white matter lesions (n?=?14 (42.4%) patients), infarct-like lesions (n?=?8 (24.2%) patients), and meningeal thickening and/or enhancement (n?=?4 (12.1%) patients). Impaired consciousness was seen in most of the patients with infarct-like lesions (87.5%) but less frequently in patients with hyperintense lesion in the pons (47.4%). We reviewed brain MRI findings in 39 patients with diffuse large B cell lymphoma with central nervous system (CNS) involvement and/or high-risk extranodal lesions for CNS involvement as a control group. In contrast to the patients with IVLBCL, no patient had hyperintense lesion in the pons in the control group (P?<?0.001). Follow-up brain MRI revealed improvement of abnormal findings in most of the patients who responded to chemotherapy. This study highlighted the diagnostic implication of hyperintense lesion in the pons on T2WI and the clinical usefulness of pretreatment brain MRI in IVLBCL even in patients without impaired consciousness. 相似文献
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Takeshi Kuwada Masahiro Shiokawa Yuzo Kodama Sakiko Ota Nobuyuki Kakiuchi Yasuhito Nannya Hajime Yamazaki Hiroyuki Yoshida Takeharu Nakamura Shimpei Matsumoto Yuya Muramoto Shuji Yamamoto Yusuke Honzawa Katsutoshi Kuriyama Kanako Okamoto Tomonori Hirano Hirokazu Okada Saiko Marui Hiroshi Seno 《Gastroenterology》2021,160(7):2383-2394.e21
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Christina Andica Koji Kamagata Takuya Hayashi Akifumi Hagiwara Wataru Uchida Yuya Saito Kouhei Kamiya Shohei Fujita Toshiaki Akashi Akihiko Wada Masahiro Abe Hiroshi Kusahara Masaaki Hori Shigeki Aoki 《Neuroradiology》2020,62(4):483-494
The reproducibility of neurite orientation dispersion and density imaging (NODDI) metrics in the human brain has not been explored across different magnetic resonance (MR) scanners from different vendors. This study aimed to evaluate the scan–rescan and inter-vendor reproducibility of NODDI metrics in white and gray matter of healthy subjects using two 3-T MR scanners from two vendors. Ten healthy subjects (7 males; mean age 30 ± 7 years, range 23–37 years) were included in the study. Whole-brain diffusion-weighted imaging was performed with b-values of 1000 and 2000 s/mm2 using two 3-T MR scanners from two different vendors. Automatic extraction of the region of interest was performed to obtain NODDI metrics for whole and localized areas of white and gray matter. The coefficient of variation (CoV) and intraclass correlation coefficient (ICC) were calculated to assess the scan–rescan and inter-vendor reproducibilities of NODDI metrics. The scan–rescan and inter-vendor reproducibility of NODDI metrics (intracellular volume fraction and orientation dispersion index) were comparable with those of diffusion tensor imaging (DTI) metrics. However, the inter-vendor reproducibilities of NODDI (CoV = 2.3–14%) were lower than the scan–rescan reproducibility (CoV: scanner A = 0.8–3.8%; scanner B = 0.8–2.6%). Compared with the finding of DTI metrics, the reproducibility of NODDI metrics was lower in white matter and higher in gray matter. The lower inter-vendor reproducibility of NODDI in some brain regions indicates that data acquired from different MRI scanners should be carefully interpreted. 相似文献
59.
Natsuko Ishida Yuya Kondo Yuri Chikano Erina Kobayashi‐Nakade Yukio Suga Junko Ishizaki Kiyonobu Komai Ryo Matsushita 《Biopharmaceutics & drug disposition》2019,40(8):294-301
Lambert‐Eaton myasthenic syndrome (LEMS) is characterized by muscle weakness, amyotrophy, easy fatigability, and depressed tendon reflexes. 3,4‐Diaminopyridine (3,4‐DAP) is the recommended therapy for the treatment of LEMS. However, estimations of 3,4‐DAP pharmacokinetics in human and animals, such as rats, are rarely reported because 3,4‐DAP is an orphan drug for the treatment of a very rare disease (LEMS). In particular, little is known about its tissue distribution. Therefore, the pharmacokinetics of 3,4‐DAP were studied, with particular focus on tissue distribution, in rats. After intravenous administration of 3,4‐DAP to rats, the half‐life of 3,4‐DAP was 15.9 ± 3.9 min and the volume of distribution at steady‐state was 2.8 ± 0.7 L/kg. The tissue‐to‐plasma partition coefficient (Kp) was high in the kidney, heart, and muscle. In addition, with increased steady state plasma concentration (Css), a tendency toward increased Kp was found in most tissues. In the muscle, a likely target region of 3,4‐DAP in LEMS patients, the Kp was higher than in the plasma. Furthermore, more than 68% of 3,4‐DAP was distributed to the muscle as determined by the ratio of 3,4‐DAP distribution calculated from the apparent volumes of distribution. Hence, 3,4‐DAP may provide for more effective and long‐lasting effects. 相似文献
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