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101.
102.
The role of oncogenes, tumour suppressor genes and growth factors in oral squamous cell carcinoma: a case of apoptosis versus proliferation 总被引:1,自引:0,他引:1
Mutation, deactivation and disregulated expression of oncogenes and tumour-suppressor genes may be involved in the pathogenesis of oral squamous cell carcinoma (SCC). Deactivation of the p53 tumour-suppressor gene allows cell proliferation and blocks apoptosis of malignant oral keratinocytes. Mutation in the ras oncog-ene results in persistent mitogenic signalling. Upregul-ated c-Myc expression, in the presence of growth factors, provides an additional proliferative signal. Loss of retino-blastoma tumour-suppressor gene (Rb) function may contribute to oral keratinocyte hyperproliferation and recent evidence suggests that simultaneous deactivation of both p53 and Rb is required for tumourigenesis. Enhanced Bcl-2 and reduced Fas expression inhibit tumour cell apoptosis and may convey resistance to cyto-toxic drugs and T cell-mediated cytotoxicity, respectively. Exogenous mutagens such as tobacco, alcohol and viral oncogenes may cause altered expression of oncogenes and tumour-suppressor genes in some cases of oral SCC. The impact of these mechanisms on future therapies for oral SCC is highlighted. 相似文献
103.
Itır Şebnem Bilici Yusuf Emes Buket Aybar Serhat Yalçın 《Journal of cranio-maxillo-facial surgery》2018,46(6):916-922
Purpose
In temporomandibular disorders (TMDs), unless splints are effective, combined therapies are performed. The aim of this study is to show the effectiveness of the local anaesthethic injections (trigger point injections) to the masticatory muscles.Materials and methods
The study was composed of TMD patients and the predictor variables were therapy combinations including stabilization splint (SS) therapy, SS+trigger point injection therapy (TPI) and arthrocentesis. The primary outcome variables were pain and jaw movements. The follow-ups were done at 1st and 3rd months. 56 patients who were treated for TMD with only SS or combined therapies were included in the study. The effects of additional TPIs were compared to SS therapy alone. Also the effect of arthrocentesis was evaluated too.Results
All groups revealed significant decreases in pain scores. Decreases in mouth openings were observed in some of the patients in the injection groups.Conclusion
The combined treatment method in which the injections were applied at shorter time intervals, was a more effective method for decreasing VAS scores in TMD patients in this study but further studies are required. 相似文献104.
105.
Prediction of subtle left ventricular systolic dysfunction in homozygous and heterozygous familial hypercholesterolemia: Genetic analyses and speckle tracking echocardiography study 下载免费PDF全文
106.
107.
Concurrent infections with two parasites: a nematode,Trichinella spiralis, and a protozoon,Toxoplasma gondii, were investigated. Antibody production (total immunoglobulin and IgM) was similar in double and single infections. However, the number ofToxoplasma cysts in the brains of mice infected withTrichinella and challenged 1–6 weeks later withToxoplasma was higher than in mice infected withToxoplasma alone, while mice infected withToxoplasma and challenged 4–14 days later withTrichinella had lower worm burdens in the intestine than animals infected withTrichinella alone. Greater loss in body weight was observed in mice infected with both parasites than in those infected with either parasite alone. 相似文献
108.
Tavil Y 《International journal of cardiology》2009,135(3):398
The concurrence of acute coronary syndrome with amoxicillin/clavulanic acid intake has been defined as Kounis syndrome. There are some controversial factors which may effect this circumstance. Particularly, the condition which triggers the coronary vasospasm may mimic this syndrome. Furthermore, in the present case, an allergic study had been performed, showing hypersensitivity to penicillin and beta-lactamic agents that ruled out the role of amoxicillin administration. 相似文献
109.
Pathak S Yusuf SW Doyle TN Francis IA Hurst PA Davidson C 《The British journal of radiology》2006,79(944):e62-e63
Aortocaval fistula (ACF) and false aneurysm are a recognized complication of open abdominal aortic aneurysm (AAA) repair. Untreated they are often fatal. However, open surgical repair of this complication is associated with a high operative mortality and a significant complication rate. Endovascular management using a stent-graft to exclude the false aneurysm and fistula is a technically feasible alternative and confers many advantages over open repair by virtue of its minimally invasive nature. We report the endovascular management of this rare but serious complication of open AAA repair. 相似文献
110.
Sonia S. Anand Francois Caron John W. Eikelboom Jackie Bosch Leanne Dyal Victor Aboyans Maria Teresa Abola Kelley R.H. Branch Katalin Keltai Deepak L. Bhatt Peter Verhamme Keith A.A. Fox Nancy Cook-Bruns Vivian Lanius Stuart J. Connolly Salim Yusuf 《Journal of the American College of Cardiology》2018,71(20):2306-2315