全文获取类型
收费全文 | 7644篇 |
免费 | 511篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 71篇 |
儿科学 | 177篇 |
妇产科学 | 210篇 |
基础医学 | 1067篇 |
口腔科学 | 371篇 |
临床医学 | 850篇 |
内科学 | 1509篇 |
皮肤病学 | 173篇 |
神经病学 | 837篇 |
特种医学 | 158篇 |
外科学 | 695篇 |
综合类 | 36篇 |
一般理论 | 9篇 |
预防医学 | 861篇 |
眼科学 | 103篇 |
药学 | 546篇 |
中国医学 | 24篇 |
肿瘤学 | 489篇 |
出版年
2024年 | 8篇 |
2023年 | 120篇 |
2022年 | 213篇 |
2021年 | 401篇 |
2020年 | 235篇 |
2019年 | 308篇 |
2018年 | 333篇 |
2017年 | 267篇 |
2016年 | 266篇 |
2015年 | 323篇 |
2014年 | 431篇 |
2013年 | 488篇 |
2012年 | 774篇 |
2011年 | 756篇 |
2010年 | 389篇 |
2009年 | 322篇 |
2008年 | 477篇 |
2007年 | 483篇 |
2006年 | 401篇 |
2005年 | 354篇 |
2004年 | 253篇 |
2003年 | 214篇 |
2002年 | 204篇 |
2001年 | 22篇 |
2000年 | 15篇 |
1999年 | 24篇 |
1998年 | 19篇 |
1997年 | 14篇 |
1996年 | 13篇 |
1995年 | 8篇 |
1994年 | 5篇 |
1993年 | 12篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 6篇 |
1989年 | 3篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有8186条查询结果,搜索用时 15 毫秒
71.
72.
Davide Firinu Vanessa Garcia-Larsen Paolo Emilio Manconi Stefano R. Del Giacco 《Current rheumatology reports》2016,18(6):35
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare autoimmune disease which, due to its clinical presentation and symptoms, is often misdiagnosed and unrecognized. Its main features are prominent inflammatory cutaneous and articular manifestations. Treatments with immunosuppressive drugs have been used for the management of SAPHO with variable results. To date, the use of anti-TNF-α agents has proved to be an effective alternative to conventional treatment for unresponsive or refractory SAPHO cases. TNF-α is a pro-inflammatory cytokine and pivotal regulator of other cytokines, including IL-1 β, IL-6, and IL-8, involved in inflammation, acute-phase response induction, and chemotaxis. IL-1 inhibition strategies with anakinra have shown efficacy as first and second lines of treatment. In this review, we will describe the main characteristics of biological drugs currently used for SAPHO syndrome. We also describe some of the promising therapeutic effects of ustekinumab, an antibody against the p40 subunit of IL-12 and IL-23, after failure of multiple drugs including anti-TNF-α and anakinra. We discuss the use and impact of the new anti-IL-1 antagonists involved in the IL-17 blockade, in particular for the most difficult-to-treat SAPHO cases. 相似文献
73.
The purpose is to examine the impact of the Implantable Miniature Telescope procedure on the level of treatment satisfaction and quality of life of individuals with end-stage age-related macular degeneration. Six individuals who had undergone the Implantable Miniature Telescope procedure were recruited. The participants completed two survey instruments about their overall quality of life and level of treatment satisfaction post intervention. In-depth interviews were also conducted to gain a perspective of the participant’s lived experience. A moderately high quality-of-life and treatment satisfaction rating was reported by participants post intervention. Qualitative themes included loss of independence, realistic perspective about the procedure, importance of rehabilitation following the procedure, and high treatment satisfaction despite lack of improvement in visual functioning. Moderately high quality-of-life ratings and treatment satisfaction were reported despite reports of limited improvements in participants’ visual function and ability to utilize the Implantable Miniature Telescope. However, qualitative responses revealed a negative impact on quality of life in relation to their diagnosis of end-stage age-related macular degeneration, but not in direct relation to the Implantable Miniature Telescope procedure. 相似文献
74.
75.
Vanessa Moñivas Palomero Alejandro Durante-Lopez Mario Torres Sanabria Javier Segovia Cubero Jesús González-Mirelis Jorge Vazquez Lopez-Ibor Sara M. Navarro Rico Isabel Krsnik Fernando Dominguez Alejandro Martinez Mingo Francisco J. Hernandez-Perez Gibanel Cavero Susana Mingo Santos 《Journal of the American Society of Echocardiography》2019,32(7):845-853.e1
76.
Sarah Yale MD Nicole Stefanko MD Patrick McCarthy MD MME Vanessa McFadden MD PhD James McCarthy MD 《Pediatric dermatology》2020,37(2):377-378
Dapsone gel is a topical treatment for facial acne in adolescents and adults, and while systemic dapsone therapy is known to be associated with methemoglobinemia, once-daily topical dapsone has been well tolerated with few side effects in large randomized controlled trials. We describe the first reported case of severe methemoglobinemia in a healthy adolescent using daily topical dapsone. Although the medication was prescribed for facial use only, the patient reported topical use over her back and chest as well. This case illustrates the potential for significant systemic dapsone absorption even with daily topical dosing and demonstrates the need for clear anticipatory guidance to prevent the potential morbidity and mortality associated with methemoglobinemia from improper topical dapsone use. 相似文献
77.
Sibylle de Germay Manuela Rueter Franois Montastruc Vanessa Rousseau Maryse Lapeyre‐Mestre Jean‐Louis Montastruc 《Fundamental & clinical pharmacology》2019,33(4):471-478
Atropinic drugs are known to potentially induce physical and/or mental impairments in the elderly. The aim of this study was to investigate trends of atropinic exposure in patients ≥65 years in France between 2006 and 2015. A repeated cross‐sectional study was performed quarterly from January 1, 2006 to December 31, 2015, in the ‘Echantillon Généraliste des Bénéficiaires (EGB)’, a representative sample of the French population. Exposed patients were identified using the Anticholinergic Durán's list. Outcomes were rate of patients exposed to at least one atropinic drug (atropinic prevalence rate) and atropinic burden per patient (sum of atropinic burden scores). Interrupted time series were used to analyze the impact of market withdrawal of some drugs with atropinic properties during the period of the study. The number of patients ≥65 years registered in the EGB ranged from 75 611 in 2006 to 95 389 in 2015. Atropinic prevalence rate decreased significantly from 45.6% in 2006 to 33.2% in 2015 (?12.4%, slope significance P < 0.05). Subjects aged ≥85 years were the most exposed. Total atropinic burden decreased significantly between 2006 and 2015 (2.2 ± 1.7 in 2006; 2.0 ± 1.5 in 2015; slope significance P < 0.05), especially in patients ≥85 years. Market withdrawals for safety reasons of some atropinic drugs were significantly associated with a decrease in the atropinic prevalence rate (P < 0.05) and atropinic burden per patient (P < 0.05). In conclusion, atropinic drug exposure in the elderly significantly decreased in France between 2006 and 2015. This decrease can be partly explained by regulatory measures against some atropinic drugs. 相似文献
78.
79.
Vanessa M. Noriega Thomas J. Gardner Veronika Redmann Gerold Bongers Sergio A. Lira Domenico Tortorella 《Viruses》2014,6(3):1202-1218
Human cytomegalovirus (HCMV) encodes a number of viral proteins with homology to cellular G protein-coupled receptors (GPCRs). These viral GPCRs, including US27, US28, UL33, and UL78, have been ascribed numerous functions during infection, including activating diverse cellular pathways, binding to immunomodulatory chemokines, and impacting virus dissemination. To investigate the role of US28 during virus infection, two variants of the clinical isolate TB40/E were generated: TB40/E-US28YFP expressing a C-terminal yellow fluorescent protein tag, and TB40/E-FLAGYFP in which a FLAG-YFP cassette replaces the US28 coding region. The TB40/E-US28YFP protein localized as large perinuclear fluorescent structures at late times post-infection in fibroblasts, endothelial, and epithelial cells. Interestingly, US28YFP is a non-glycosylated membrane protein throughout the course of infection. US28 appears to impact cell-to-cell spread of virus, as the ΔUS28 virus (TB40/E-FLAGYFP) generated a log-greater yield of extracellular progeny whose spread could be significantly neutralized in fibroblasts. Most strikingly, in epithelial cells, where dissemination of virus occurs exclusively by the cell-to-cell route, TB40/E-FLAGYFP (ΔUS28) displayed a significant growth defect. The data demonstrates that HCMV US28 may contribute at a late stage of the viral life cycle to cell-to-cell dissemination of virus. 相似文献