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排序方式: 共有1141条查询结果,搜索用时 15 毫秒
991.
Lisa Buckmiller MD Umesh Dyamenahalli MD Gresham T. Richter MD 《The Laryngoscope》2009,119(10):2051-2054
Infantile hemangiomas arising in the trachea are rare. These lesions pose a management dilemma as several treatment options can provide safe management. Propranolol, a nonselective beta‐blocker, has recently been introduced as a novel modality for the treatment of proliferating hemangiomas. This report illustrates the successful management of tracheal hemangiomas using oral propranolol in a young patient with otherwise treatment‐resistant airway lesions. Despite various endoscopic therapeutic attempts, the patient remained stridulous with airway disease that persisted into the involution phase of the average hemangioma cycle. Within 6 weeks of beginning oral propranolol (2 mg/kg/day), her airway compromise was eliminated and she had complete resolution of endoscopically visible disease. No side effects from propranolol occurred. We propose that oral propranolol should be considered for use in airway hemangiomas. Laryngoscope, 2009 相似文献
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Umesh Mahantshetty Tanuja Teni Pushpa Naga Chandni Hotwani Sumuki Umesh Sadhana Kannan Vinod Hande Sagar Pawar Reena Engineer Supriya Chopra Kedar Deodhar Amita Maheshwari Lavanya Gurram Sudeep Gupta Shyam Kishore Shrivastava 《Gynecologic oncology》2018,148(2):299-304
Objective
With an aim to investigate the impact of Human Papilloma Virus (HPV) 16/18 infection on clinical outcomes in locally advanced cervical cancers treated with radical radio (chemo) therapy, we undertook this prospective study.Methods
Between May 2010 and April 2012, 150 histologically proven cervical cancer patients treated with radio (chemo) therapy were accrued. Cervical biopsies/brushings were collected at pre-treatment, end of treatment and at 3 monthly intervals up to 24 months. Quantitative estimation of HPV 16/18 was done using real-time polymerase chain reaction (RT-PCR) and correlated with various clinical end-points.Results
Out of 150 patients accrued, 135 patients were considered for final analysis. Pre-treatment HPV16/18 DNA was detected in 126 (93%) patients, with HPV-16 present in 91%. The mean log (± SD) HPV-16 and HPV-18 viral load at pre-treatment was 4.76 (± 2.5) and 0.14 (± 2.1) copies/10 ng of DNA, respectively. Though significant decline in viral load was observed on follow-ups (p < 0.0001); by 9-month follow-up, 89 (66%) patients had persistence of HPV infection. Patients with persistent HPV 16/18 infection had a significantly higher overall and loco-regional relapses [44/89 (49%) and 29/89 (32%)] as compared to HPV clearance by 9 months [12/43 (28%) and 5/43 (11%)] with p = 0.024 and p = 0.02, respectively. Also, persistent HPV infection by 24-month showed a significant impact on loco-regional control (LRC) and recurrence-free survival (RFS).Conclusion
In locally advanced cervical cancers treated with radical radio (chemo) therapy, persistent HPV 16/18 infection is significantly high in immediate post-treatment period and correlated with higher loco-regional, overall relapses and was also associated with early relapses. 相似文献995.
Manas Pratim Roy H. P. S. Sachdev Umesh Kapil Naveen Kumar Bhardwaj Neeraj Gupta Mahendra Kumar Gupta Sandeep Agarwala Alisha Gupta Devi Dayal Nimisha Jain Anuradha Khadilkar Vaman V. Khadilkar Shahid Akhtar Siddiqui Amruta Pendse Bonny Jasani Jogender Kumar Amitabh Singh Deep Dutta Anu Thukral Ashok K. Deorari 《Indian pediatrics》2018,55(1):75-82
996.
Do patients have worse outcomes in heart failure than in cancer? A primary care‐based cohort study with 10‐year follow‐up in Scotland 下载免费PDF全文
997.
Efficacy,safety, and pharmacokinetics of simeprevir,daclatasvir, and ribavirin in patients with recurrent hepatitis C virus genotype 1b infection after orthotopic liver transplantation: The Phase II SATURN study 下载免费PDF全文
Xavier Forns Marina Berenguer Kerstin Herzer Martina Sterneck Maria Francesca Donato Pietro Andreone Stefano Fagiuoli Tomasz Cieciura Magdalena Durlik Jose Luis Calleja Zoe Mariño Umesh Shukla Thierry Verbinnen Oliver Lenz Sivi Ouwerkerk‐Mahadevan Monika Peeters Katrien Janssen Ronald Kalmeijer Wolfgang Jessner 《Transplant infectious disease》2017,19(3)
998.
Mohan CV Phillips MJ Bhat BV Umesh NR Padiyar PA 《Revue scientifique et technique (International Office of Epizootics)》2008,27(1):161-173
Disease is one of the gravest threats to the sustainability of the aquaculture industry. A good understanding of biosecurity and disease causation is essential for developing and implementing farm-level plans and husbandry measures to respond to disease emergencies. Using epidemiological approaches, it is possible to identify pond- and farm-level risk factors for disease outbreaks and develop intervention strategies. Better management practices (BMPs) should be simple, science-based, cost-effective and appropriate to their context if farmers are to adopt and implement them. As part of a regional initiative by the Network of Aquaculture Centres in Asia-Pacific (NACA) to control aquatic animal diseases, effective extension approaches to promote the widespread adoption of BMPs have been developed in India, Indonesia, Vietnam and Thailand, and have proved their worth. A highly successful programme, which addresses rising concerns about the effect of disease on the sustainability of shrimp farming in India, is now in its seventh year. In this paper, the authors present a brief insight into the details of the programme, its outcomes and impact, the lessons learned and the way forward. 相似文献
999.
Vinodkumar R Vaidya SD Siva Kumar BV Bhise UN Bhirud SB Mashelkar UC 《European journal of medicinal chemistry》2008,43(5):986-995
Synthesis of a series of novel and functionalized benzimidazole derivatives by the condensation of OPDA with 4-bromobenzoic acid and subsequent reactions of the product obtained with phenylacetylene and 6-ethynyl-4,4-dimethylthiochroman utilising Sonogashira coupling has been reported. The Sonogashira coupling products were then alkylated at the benzimidazole -NH with different electrophilic reagents leading to functionalized derivatives. All the compounds synthesized were screened for their potential anti-bacterial, anti-asthmatic and anti-diabetic properties, which exhibited moderate activities in screening studies in vitro. 相似文献
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