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111.
Kerem Inanoglu Dilek Ozcengiz Yasemin Gunes Hakki Unlugenc Geylan Isik 《Journal of anesthesia》2010,24(5):700-704
Purpose
In this study, we aimed to compare the effects of ropivacaine alone and ropivacaine plus tramadol administered epidurally for postoperative analgesia in children. 相似文献112.
Fatih Kose Ayberk Besen Saime Paydas Mustafa Balal Gulfiliz Gonlusen Tamer Inal Ayse Dogan Mustafa Kibar 《Clinical and experimental nephrology》2010,14(1):22-27
Background
Nonsteroidal anti-inflammatory drugs act by inhibiting the rate-limiting enzymes cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2), which are important in prostanoid formation. The aim of this experimental study was to examine the effects of selective Cox-2 inhibitor, rofecoxib, with or without furosemide, on urine and serum electrolytes, creatinine clearance, plasma renin activity (PRA), and Cox-2 expression in the renal cortex. 相似文献113.
Filiz Özülker Tamer Özülker Aysun Küçüköz Uzun Tevfik Özpaçacı 《Medical oncology (Northwood, London, England)》2011,28(4):1101-1106
In this study, we investigated the efficacy of 99mTc-DTPA scintigraphic analysis of GFR with the Gates method in comparison
with the measurement of plasma urea and creatinine, in the detection of nephrotoxicity occurred in patients treated with cisplatin.Twenty-six
male patients with a mean age of 26.73 ± 6.39 years (age range 15–42) who had seminomatous and nonseminomatous testicular
carcinoma were included in our study. The patients received cisplatin with a dose of 20 mg/m2 per day for five consecutive days repeated every 21 days. Before starting chemotherapy, immediately after the end of four cycles
of chemotherapy and 7 months after the beginning of chemotherapy, plasma urea and creatinine levels were measured and simultaneously
scintigraphic GFR estimation using 99 mTc-DTPA with the Gates method was performed. In the measurements done immediately after
the chemotherapy, in 18 of the 26 patients GFR levels decreased, in 4 of the 8 remaining patients GFR did not change, and
in 4 patients there was an increase in the GFR levels. The changes in the averages of the plasma urea and creatinine levels
between measurements done before and after the chemotherapy were not statistically significant. The decrease in the average
of the GFR values immediately after chemotherapy, in comparison to the average of GFR values measured before chemotherapy,
was found to be statistically significant with paired sample t test analysis (P < 0.009 with 95% CI). We concluded that scintigraphic GFR measurement using the Gates method with 99mTc-DTPA is a suitable
method in the diagnosis of nephrotoxicity occuring due to cisplatine. 相似文献
114.
Tamer A. Gheita Yasser Ezzat Safaa Sayed Ghada El-Mardenly Waleed Hammam 《Clinical rheumatology》2010,29(2):181-188
To detect and describe the incidence of musculoskeletal manifestations in different malignant diseases as well as their relation
to the treatment received whether by chemotherapy or radiation therapy. Sixty patients with different malignant diseases were
included in this study, 45 with solid tumors and 15 patients with hematological malignancy. The mean age was 46.55 ± 11.04 years
and the mean disease duration was 2 ± 0.75 years. The patients were fully examined for any rheumatologic involvement, laboratory
investigations were performed as well as dual energy X-ray absorptiometry study for bone densitometry. Treatment strategies
were assessed including the chemotherapeutics, radiation therapy, and/or surgery. Myalgias and arthralgias were the most frequent
followed by flexor tenosynovitis, frozen shoulder, and fibromyalgia syndrome. Hypertrophic osteoarthropathy was seen in five
patients, cutaneous vasculitis in two patients as well as arthritis. Osteonecrosis was present in one of the lunate carpal
bones of a patient with non-Hodgkin’s lymphoma (1.67%) and receiving high dose steroids. Rheumatoid factor was positive in
four patients, three of which had hepatitis C virus positivity and cryoglobulins. Anti-neutrophil cytoplasmic antibody was
negative in all the studied patients. The bone mineral density was significantly reduced in the patients with malignancy compared
to the control. Mild to moderate osteoporosis was present, being more evident in the spine and forearm. The bone loss was
higher in those with solid tumors and even more obvious in those receiving aromatase inhibitors. Musculoskeletal manifestations
occurring during malignancies and following the treatment represent a significant percentage of symptoms and signs which may
raise a clue to differential diagnosis. 相似文献
115.
116.
Tugrul Akin Umit Aykan Koray Karadayi Ali Aydin Tamer Fazil Yildiz Ahmet Hamdi Bilge 《Ophthalmic surgery, lasers & imaging》2007,38(6):520-522
The authors describe a technique for performing a safe and controlled continuous curvilinear capsulorhexis (CCC) in white cataracts using the contrast-enhancing effect of green light from an endoillumination probe. After attaching a green filter to the endoillumination unit of the vitrectomy set, a CCC was performed under the green light of the endoillumination probe, which was placed on the periphery of the cornea in a manner that followed the tearing edge of the capsulorhexis. This technique may be an alternative to capsular dyes in performing a safe and controlled CCC in white cataracts. 相似文献
117.
A M Tamer L B Friedman S R Maxwell H A Cynamon H N Perez W W Cleveland 《The Journal of pediatrics》1985,107(1):14-19
A prospective randomized study of 100 well-nourished infants with acute gastroenteritis resulting in dehydration and acidosis was carried out at the Jackson Memorial Hospital, Miami from 1981 to 1983. Patients were randomly assigned to receive either standard intravenous therapy or oral rehydration. Infants in the latter group first received solution A containing 75 mEq/L sodium, 30 mEq/L potassium, 75 mEq/L chloride [corrected], 30 mEq/L bicarbonate, and 2 gm/dL glucose [corrected]. After ad libitum feeding for six hours, solution B containing 50 mEq/L sodium, 30 mEq/L potassium, 50 mEq/L chlorine, 30 mEq/L bicarbonate, and 3 gm/dL [corrected] glucose was given. With three exceptions (6%), oral rehydration was comparable to the intravenous regimen in clinical estimates of improvement, although the oral group had more stools in the first day. The oral group had faster correction of acidosis and a sustained rise in serum potassium concentration, whereas in the intravenous group the potassium concentration showed first a drop with a later increase, but levels were at all times below those in the oral group. Although potassium was given from the beginning of oral rehydration, and at a higher concentration than recommended by the World Health Organization, no hyperkalemia occurred. We concluded that oral therapy is safe, less expensive for patients, and more convenient for the medical and nursing staffs. 相似文献
118.
Conclusion Management of UTI in children—the most challenging task because of the reasons explained earlier can be thus made easy by;
(a) proper diagnosis which includes high index of suspicion and finding out asymptomatic cases through mass screening especially
of young infants; and (b) treating these cases with appropriate antibiotics therapy as short course therapy for simple infection,
chronic suppressive therapy for recurrent infections and intensive therapy for acute upper urinary tract infection. Follow
up of such children in a special clinic set up in large equipped hospital will minimise the risk of future renal complications. 相似文献
119.
Recently, case reports of patients with primary pulmonary hypertension (PPH) treated with sildenafil demonstrated encouraging results. The mechanism proposed is a relatively selective pulmonary vasodilation via increased levels of cGMP because of the inhibition of phosphodiesterase type 5. Two siblings with a similar medical history, severe symptoms and elevated levels of pulmonary artery pressures were diagnosed with PPH after a thorough diagnostic work-up. Both patients were treated with coumadin, sildenafil, furosemide, spironolactone and digoxin. One of the patients had no improvement during the hospital course and died two months after discharge. The other patient improved dramatically during the hospital course, and this improvement was sustained. At the three-month follow-up control, she was much improved in terms of clinical status and echocardiographic findings. 相似文献
120.
OBJECTIVE: Ischemia plays an important role in the development of pathological changes in nerve tissue, and restoration of blood flow results in injury (ischemia/reperfusion [I/R] injury) mediated by toxic oxygen free radicals. Trapidil is currently used as a coronary artery vasodilating agent and is also used for the prevention of ischemic symptoms of cerebral vasospasm. The purpose of this study was to determine the effects of trapidil on I/R injury and the ischemic tolerance of rat peripheral nerves. METHODS: Preischemia or prereperfusion administration of trapidil (8 mg/kg) was evaluated in the rat sciatic nerve I/R injury model. Nerve tissue samples from the I/R injury site were assayed for malondialdehyde (MDA), nitrites, and nitrates, as markers of I/R injury, and pathological changes were evaluated by electron microscopy. RESULTS: I/R resulted in an increase in MDA levels, which remained elevated for 2 weeks in control nerves. Rats that received trapidil before ischemia exhibited decreased MDA levels, and rats that received trapidil after the standard 3 hours of ischemia demonstrated increased tolerance to reperfusion, as reflected in significantly decreased MDA levels. Nitrite and nitrate levels in trapidil-treated rats were significantly higher than those in control animals. Histological evaluations of the sciatic nerve segments demonstrated that preischemia and postischemia trapidil treatments had a sparing effect against the myelin damage and axonal edema that are consistently noted in untreated ischemic reperfused nerves. CONCLUSION: The results confirm that pretreatment with trapidil before the ischemic insult or before reperfusion provides marked protection against I/R injury in peripheral nerves. 相似文献