愈合时间和微动效应对种植义齿形成骨性结合的影响

种植体与周围骨组织界面之间形成骨性结合是种植体在颌骨中获得稳定固位的组织学基础,而种植体植入颌骨后的无负荷愈合时间和种植体的微动效应是决定骨性结合能否形成的关键因素,相关的研究也一直是种植义齿研究领域的热点之一.本文对种植义齿愈合时间以及微动效应的研究进程和相关理论的发展进行了综述.     

Diabetic retinopathy identification based on multi-source-free domain adaptation

AIM: To address the challenges of data labeling difficulties, data privacy, and necessary large amount of labeled data for deep learning methods in diabetic retinopathy (DR) identification, the aim of this study is to develop a source-free domain adaptation (SFDA) method for efficient and effective DR identification from unlabeled data. METHODS: A multi-SFDA method was proposed for DR identification. This method integrates multiple source models, which are trained from the same source domain, to generate synthetic pseudo labels for the unlabeled target domain. Besides, a softmax-consistence minimization term is utilized to minimize the intra-class distances between the source and target domains and maximize the inter-class distances. Validation is performed using three color fundus photograph datasets (APTOS2019, DDR, and EyePACS). RESULTS: The proposed model was evaluated and provided promising results with respectively 0.8917 and 0.9795 F1-scores on referable and normal/abnormal DR identification tasks. It demonstrated effective DR identification through minimizing intra-class distances and maximizing inter-class distances between source and target domains. CONCLUSION: The multi-SFDA method provides an effective approach to overcome the challenges in DR identification. The method not only addresses difficulties in data labeling and privacy issues, but also reduces the need for large amounts of labeled data required by deep learning methods, making it a practical tool for early detection and preservation of vision in diabetic patients.     

基于医务人员视角的远程医疗服务使用意愿和关键问题研究

目的:分析我国医务人员远程医疗服务使用意愿和关键问题,以完善远程医疗服务体系。方法:2019年10—11月,对福建、海南、河南、湖南、贵州、四川和青海7个省份中已参与过远程医疗的邀请方和受邀方医务人员进行电子问卷调查,主要内容为医务人员对远程医疗的使用意愿、满意度情况和认知评价情况等。通过描述性统计分析和非参数检验,探...     

The Biomarkers for Predicting Viral Hepatitis-Associated Hepatocellular Carcinoma

BackgroundHepatocellular carcinoma (HCC) is the fifth most common cancer in the world, and more than half of the newly diagnosed cases are chronic hepatitis B patients. Due to the lack of specific clinical manifestations, many patients are already at an advanced stage at the time of diagnosis and therefore have missed the best time for treatment. Organs in a pathological state usually secrete specific substances into the blood, which can indirectly indicate the pathological state of the organ, so some biological markers in the blood can be used as a tool to predict the incidence of HCC.MethodsThe Research articles related to HCC were collected by searching PubMed databases with the keywords “hepatocellular carcinoma”, “serum biomarker”, “hepatitis B”, “prediction” and “prognosis”, and Additional articles were identified by manual search of references found in the primary articles, followed by a summary and review.ResultsViral hepatitis is the main cause of HCC worldwide, and this phenomenon is particularly prominent in Asian and African populations. A variety of serological markers including M2BPGi, IL-6 and COMP can be used to predict the incidence of long-term HCC in patients. The risk of HCC is dynamic rather than constant, and dynamic detection will help improve prediction accuracy. For hepatitis B patients, HBV DNA load and HBcr Ag are important predictive markers of HCC.ConclusionFor a high-risk population of HCC, early risk prediction is helpful to guide clinical work, and timely adjustments of the screening frequency and treatment plan are helpful to prolong the survival time of HCC patients.     

复式脉冲体外碎石机的临床应用分析

目的总结复式脉冲体外碎石治疗泌尿系结石的经验。方法应用复式脉冲体外碎石机治疗泌尿系结石患者1206例,其中肾结石508例,输尿管结石603例,膀胱结石95例,结石大小0.4cm×0.5cm~2.5cm×2.5cm。碎石机工作电压4~8.5kV,放电次数1500~3000。结果肾结石的治愈率58.3%(296/508),输尿管结石的治愈率72.7%(438/603),膀胱结石的治愈率82.4%(78/95),并发症:81.8%(986/1206)的患者复式脉冲体外碎石治疗后有不同程度肉眼血尿,13.6%(164/1206)的患者出现肾绞痛,14例患者治疗后出现高热,2例患者出现肾被膜下血肿。结论体外复式脉冲碎石技术应作为泌尿系结石的首选治疗方法。     

一肾一夹肾血管性高血压动物模型的制作

目的研究一肾一夹(1K1C)肾血管性高血压动物模型的制作。方法选用200~220 g体重的SD大鼠,制作1K1C高血压大鼠模型。随机分为正常对照组、单肾对照组(1K)、1K1C组、1K1C+BEA组。使用药物2-溴乙胺氢溴酸盐(BEA)破坏肾髓质。采用尾动脉袖套法测量各组大鼠血压的变化。结果1K组大鼠血压4周后有明显升高,与正常对照组比较,差异有统计学意义(P<0.05),但是1K组大鼠与正常对照组大鼠4周后血压远未达到肾血管性高血压入选标准;1K1C组大鼠血压在1周后开始升高,2周时已达到本实验高血压入选标准;1K1C+BEA组血压升高更明显,4周时血压与1K1C组比较,差异有统计学意义(P<0.05)。结论本方法制作肾血管性高血压模型简单易行,成功率约80%。     

单一髂腹股沟入路治疗髋臼双柱骨折的疗效分析

目的:探讨单一髂腹股沟入路手术治疗髋臼双柱骨折的疗效.方法:选取2008年7月至2016年7月我院骨科收治的髋臼双柱骨折患者60例为研究对象,采用单一髂腹股沟入路手术成功复位后,前柱骨折运用重建接骨板螺钉固定,后柱骨折以拉力螺钉固定骨折端.按照Matta标准评估骨折复位情况,采用改良Merle D'Aubigne an...     

早期新生儿黄疸的动态监测及早期干预治疗效果评价

目的观察出生1周内新生儿黄疸的动态变化、高胆红素血症患儿病因分析及早期干预治疗的效果。方法利用经皮胆红素测定仪对我院产科出生的928例新生儿每日进行同一部位的皮肤测定,根据新生儿不同出生情况对超过胆红素值安全范围的及时给予口服药物或转儿科蓝光治疗。结果928例新生儿因高胆红素血症住院156例,高胆红素血症发生率为15.74%,无1例发生胆红素脑病。结论对新生儿黄疸进行监测和早期干预治疗,可大幅度降低高胆红素血症的发病率,从而防止胆红素脑病的发生。     

边防海岛战士心理健康状况及人格特征与应对方式的研究

目的了解边防海岛战士的心理健康状况,人格特征及应对方式的关系。方法采用症状自评量表(SCL-90)、艾森克个性问卷(EPQ)和简易应对方式问卷对960名边防海岛战士进行心理测试,了解他们心理健康状况,人格特征和应对方式特点及其影响因素。结果(1)边防海岛战士SCL-90各因子分均显著高于军人常模;(2)边防海岛战士应对方式与心理健康状况密切相关,积极应对方式与SCL-90某些因子相关,消极应对方式与SCL-90各因子均呈显著正相关(P<0.01);(3)边防海岛战士在面对应激时所采取的应对方式与人格特征密切相关,消极应对方式与人格问卷中的P分(精神质)和N分(神经质)有显著或高度显著正相关(P<0.01),积极应对方式与人格问卷中的P分(精神质)呈负相关,和E分(内外向)呈正相关。结论边防海岛战士心理健康状况差于军人总体水平,人格特征及应对方式对心理健康水平有较大影响。