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991.
992.
Background
The treatment of Morton’s neuroma (MN) can be operative, conservative and infiltrative. Our aim was the evaluation of evidence on outcomes with different types of conservative, infiltrative and surgical treatment in patients affected by primary MN.Methods
The bibliographic search was conducted in MEDLINE, Cochrane Library, DARE. Only studies in English were collected. The last search was in August 2015. Case series and randomized controlled trials (RCTs) assessing patients’ satisfaction or pain improvement at an average follow-up of at least 6 months after treatment of primary MN were included. Two reviewers selected the studies, evaluated their methodological quality, and retrieved data independently.Results
Of 283 titles found, only 29 met the inclusion criteria. Data showed better outcomes with operative treatment.Conclusions
The evaluated case series and few RCTs showed better results with invasive treatment. More and better RCTs which evaluate risk-benefit ratio are required to confirm these results. 相似文献993.
Gerhard Schumann Roberto Bonora Ferruccio Ceriotti Georges Férard Carlo A Ferrero Paul F H Franck F Javier Gella Wieland Hoelzel Poul J?rgen J?rgensen Takashi Kanno Art Kessner Rainer Klauke Nina Kristiansen Jean-Marc Lessinger Thomas P J Linsinger Hideo Misaki Mauro Panteghini Jean Pauwels Fran?oise Schiele Heinz G Schimmel Gerhard Weidemann Lothar Siekmann 《Clinical chemistry and laboratory medicine》2002,40(7):718-724
This paper is the fourth in a series dealing with reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 degrees C and the certification of reference preparations. Other parts deal with: Part 1. The Concept of Reference Procedures for the Measurement of Catalytic Activity Concentrations of Enzymes; Part 2. Reference Procedure for the Measurement of Catalytic Concentration of Creatine Kinase; Part 3. Reference Procedure for the Measurement of Catalytic Concentration of Lactate Dehydrogenase; Part 5. Reference Procedure for the Measurement of Catalytic Concentration of Aspartate Aminotransferase; Part 6. Reference Procedure for the Measurement of Catalytic Concentration of Gamma-Glutamyltransferase; Part 7. Certification of Four Reference Materials for the Determination of Enzymatic Activity of Gamma-Glutamyltransferase, Lactate Dehydrogenase, Alanine Aminotransferase and Creatine Kinase at 37 degrees C. A document describing the determination of preliminary upper reference limits is also in preparation. The procedure described here is deduced from the previously described 30 degrees C IFCC reference method. Differences are tabulated and commented on in Appendix 2. 相似文献
994.
Schauer U Stemberg F Rieger CH Borte M Schubert S Riedel F Herz U Renz H Wick M Carr-Smith HD Bradwell AR Herzog W 《Clinical chemistry》2003,49(11):1924-1929
BACKGROUND: There is currently no international reference preparation for IgG subclass (IgGSc) quantification. This situation has led to calibration differences among assays and a variety of reference interval values with consequential difficulties in comparing results. We therefore evaluated IgGSc concentrations in Certified Reference Material 470 (CRM 470). METHODS: Pure, polyclonal IgG1, -2, -3, and -4 were prepared from a large serum pool for use as primary standards. The IgG mass in each preparation was calculated from amino-acid analysis data. IgGSc concentrations were assessed in CRM 470 by nephelometry with modern analytical techniques, using these reference preparations. Subsequently, IgGSc concentrations were measured in 380 healthy individuals (250 males and 130 females), and age-dependent reference intervals were established. RESULTS: IgGSc concentrations in CRM 470 were as follows: IgG1, 5028 mg/L; IgG2, 3418 mg/L; IgG3, 579 mg/L, and IgG4, 381 mg/L, with a total IgG concentration of 9406 mg/L, 2.83% below the certified total IgG value of 9680 mg/L. Age-dependent percentile curves for the four IgGSc were constructed using a Box-Cox transformation. Maximum median values were as follows: IgG1, 6.02 g/L at 11 years; IgG2, 3.45 g/L at 31 years; IgG3, 0.63 g/L at 17 years; and IgG4, 0.48 g/L at 14 years. No significant sex-related differences were observed. CONCLUSIONS: The correlation between the summation of individual IgGSc and separate measurements of total IgG concentrations was good and supports the accuracy of the results. The results are based on The Binding Site assays and should not be considered appropriate for other assays unless so demonstrated. 相似文献
995.
996.
Hans-Dirk?Düngen Svetlana?Apostolovi? Simone?Inkrot Elvis?Tahirovi? Florian?Krackhardt Milan?Pavlovi? Biljana?Putnikovi? Mitja?Lain??ak G?tz?Gelbrich Frank?Edelmann Rolf?Wachter Thomas?Eschenhagen Finn?Waagstein Ferenc?Follath Mathias?Rauchhaus Wilhelm?Haverkamp Karl-Josef?Osterziel Rainer?Dietz 《Clinical research in cardiology》2008,97(9):578-586
Background Chronic heart failure (CHF) is a widespread disease with severe quality of life impairment and a poor prognosis. Beta-blockers
are the mainstay of CHF therapy; yet they are under-prescribed and under-dosed in clinical practice. This is particularly
evident in elderly patients, which may be due to a fear of side-effects or intolerance. Beta-blockers have further not been
adequately tested in patients with diastolic CHF, which is particularly common in elderly patients. Finally, comparative data
on the use of different beta-blockers in patients with CHF is scarce.
Aim To compare the tolerance of bisoprolol and carvedilol in elderly patients with CHF.
Methods CIBIS-ELD is an investigator-initiated, multi-centre, 1:1 randomised, double-blind, phase III trial comparing bisoprolol and
carvedilol in patients ≥65 years with systolic or diastolic CHF. Recruitment started in April 2005 and is anticipated to be
completed by April 2008 with at least 800 patients enrolled.
Perspective This is the first large scale head to head beta-blockers trial in an elderly population with CHF. Besides determining which
of two standard beta-blockers is best tolerated in elderly patients with systolic or diastolic CHF, we expect to gain further
insight into the treatment of the particular population of patients with diastolic CHF.
This trial was supported by the Competence Network of Heart Failure funded by the Federal Ministry of Education and Research
(BMBF, project number 01GI0205) and is registered with number ISRCTN34827306 at . 相似文献
997.
Carlo V. Feo Alessandro De Troia Massimo Pedriali Simone Sala Maria Chiara Zatelli Paolo Carcoforo Claudio F. Feo 《BMC surgery》2018,18(1):103
Background
Adrenal cavernous hemangiomas are very rare benign tumors that usually present as incidental findings on abdominal imaging. Preoperative differential diagnosis from other benign or malignant adrenal neoplasms may be challenging.Case presentation
A 70-year old man was referred for an 8-cm abdominal mass incidentally discovered on a contrast-enhanced computed tomography (CT) performed to investigate a pulmonary nodule. Biochemical tests ruled out any endocrine dysfunction and iodine 123 metaiodobenzylguanidine whole body scintiscan single-photon emission CT excluded a pheocromocitoma. Findings on magnetic resonance imaging were non-specific and the patient was elected for a left adrenalectomy. Histopathological diagnosis revealed a cavernous hemangioma. A portion of the resected tissue was tested for drug sensitivity to mitotane, doxorubicin, and sunitinib.Conclusions
Adrenal hemangioma is a rare disease but should be included in the differential diagnosis of adrenal tumors. The surgical resection is generally required to exclude malignant disease, resolve pressure-related symptoms, and prevent retroperitoneal hemorrhage. Although specific features in diagnostic imaging are often lacking, if the diagnosis is established preoperatively a laparoscopic adrenalectomy can be performed due to the benign nature of the lesion. Doxorubicin and sunitinib were both capable of reducing primary culture cell viability, this suggest that similar drugs may be useful in the medical treatment of adrenal hemangiomas.998.
Renzo Rozzini Angelo Bianchetti Simone Franzoni Orazio Zanetti Marco Trabucchi 《Journal of cross-cultural gerontology》1991,6(1):83-90
Health status, functional status, and social influences were analyzed as risk factors associated with mortality in 1201 elderly subjects (70–75 years old), living in the center of Brescia, Northern Italy, followed up for three years.Mortality was positively associated with degree of impairment in health status, functional status, and mental status as measured by cognitive function and mood depression. Among social conditions no relation was found between mortality and living alone, education, or income, while a significant inverse relationship has been found between mortality and activities. In defining risk factors of mortality in aged people not only health status and cognitive function have to be taken into account but also social activities; these latter may act as protective factors buffering the organism from the effects of noxious stimuli.Paper originally presented at the XIVth International Congress of Gerontology, Acapulo, Mexico 18–23 June 1989. 相似文献
999.
Chinali M de Simone G Wachtell K Gerdts E Gardin JM Boman K Nieminen MS Papademetriou V Dahlöf B Devereux RB 《Journal of hypertension》2008,26(7):1472-1476
In hypertensive patients without prevalent cardiovascular disease, enhanced left atrial systolic force is associated with left ventricular hypertrophy and increased preload. It also predicts cardiovascular events in a population with high prevalence of obesity. Relations between left atrial systolic force and left ventricular geometry and function have not been investigated in high-risk hypertrophic hypertensive patients. Participants in the Losartan Intervention For Endpoint reduction in hypertension echocardiography substudy without prevalent cardiovascular disease or atrial fibrillation (n = 567) underwent standard Doppler echocardiography. Left atrial systolic force was obtained from the mitral orifice area and Doppler mitral peak A velocity. Patients were divided into groups with normal or increased left atrial systolic force (>14.33 kdyn). Left atrial systolic force was high in 297 patients (52.3%), who were older and had higher body mass index and heart rate (all P < 0.01) but similar systolic and diastolic blood pressure, in comparison with patients with normal left atrial systolic force. After controlling for confounders, increased left atrial systolic force was associated with larger left ventricular diameter and higher left ventricular mass index (both P < 0.01). Prevalence of left ventricular hypertrophy was greater (84 vs. 64%; P < 0.001). Participants with increased left atrial systolic force exhibited normal ejection fraction; higher stroke volume, cardiac output, transmitral peak E velocities and peak A velocities; and lower E/A ratio (all P < 0.01). Enhanced left atrial systolic force identifies hypertensive patients with greater left ventricular mass and prevalence of left ventricular hypertrophy, but normal left ventricular chamber systolic function with increased transmitral flow gradient occurring during early filling, consistent with increased preload. 相似文献
1000.
Pasqualina Laganà Gabriella Caruso Ilaria Corsi Elisa Bergami Valentina Venuti Domenico Majolino Rosabruna La Ferla Maurizio Azzaro Simone Cappello 《International journal of hygiene and environmental health》2019,222(1):89-100
The retrieval of a polystyrene macro-plastic piece stranded on the shores in King George Island (South Shetlands, Antarctica) gave the opportunity to explore the associated bacterial flora. A total of 27 bacterial isolates were identified by molecular 16s rRNA gene sequencing and 7 strains were selected and screened for their ability to produce biofilm and antibiotic susceptibility profiles. All the bacterial isolates were able to produce biofilm. The Kirby-Bauer disk diffusion susceptibility test to 34 antibiotics showed multiple antibiotic resistances against the molecules cefuroxime and cefazolin (belonging to cephalosporins), cinoxacin (belonging to quinolones) and ampicillin, amoxicillin + clavulanic acid, carbenicillin and mezlocillin (belonging to beta-lactams). The obtained results suggest that plastics can serve as vectors for the spread of multiple resistances to antibiotics across Antarctic marine environments and underline the relevance of future studies on this topic. 相似文献