全文获取类型
收费全文 | 8582篇 |
免费 | 609篇 |
国内免费 | 89篇 |
专业分类
耳鼻咽喉 | 105篇 |
儿科学 | 296篇 |
妇产科学 | 292篇 |
基础医学 | 929篇 |
口腔科学 | 160篇 |
临床医学 | 930篇 |
内科学 | 1846篇 |
皮肤病学 | 215篇 |
神经病学 | 863篇 |
特种医学 | 228篇 |
外科学 | 1402篇 |
综合类 | 166篇 |
一般理论 | 3篇 |
预防医学 | 416篇 |
眼科学 | 139篇 |
药学 | 645篇 |
中国医学 | 70篇 |
肿瘤学 | 575篇 |
出版年
2023年 | 35篇 |
2022年 | 76篇 |
2021年 | 219篇 |
2020年 | 106篇 |
2019年 | 197篇 |
2018年 | 236篇 |
2017年 | 166篇 |
2016年 | 186篇 |
2015年 | 253篇 |
2014年 | 313篇 |
2013年 | 434篇 |
2012年 | 564篇 |
2011年 | 624篇 |
2010年 | 378篇 |
2009年 | 355篇 |
2008年 | 519篇 |
2007年 | 508篇 |
2006年 | 520篇 |
2005年 | 461篇 |
2004年 | 448篇 |
2003年 | 326篇 |
2002年 | 309篇 |
2001年 | 275篇 |
2000年 | 216篇 |
1999年 | 217篇 |
1998年 | 59篇 |
1997年 | 60篇 |
1996年 | 54篇 |
1995年 | 33篇 |
1994年 | 45篇 |
1993年 | 44篇 |
1992年 | 100篇 |
1991年 | 102篇 |
1990年 | 104篇 |
1989年 | 97篇 |
1988年 | 80篇 |
1987年 | 71篇 |
1986年 | 58篇 |
1985年 | 56篇 |
1984年 | 54篇 |
1983年 | 37篇 |
1982年 | 16篇 |
1981年 | 25篇 |
1980年 | 20篇 |
1979年 | 40篇 |
1978年 | 23篇 |
1977年 | 20篇 |
1976年 | 23篇 |
1975年 | 19篇 |
1974年 | 23篇 |
排序方式: 共有9280条查询结果,搜索用时 15 毫秒
141.
Longitudinal urinary metabolomic profiling reveals metabolites for asthma development in early childhood
下载免费PDF全文
![点击此处可从《Pediatric allergy and immunology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
142.
143.
144.
145.
Erythema elevatum diutinum (EED) is a rare chronic form of leukocytoclastic vasculitis with unknown etiology. EED has been
described in association with hematological malignancies, infections and a number of rheumatological diseases. We report a
patient with systemic lupus erythematosus (SLE) who presented with intermittent attacks of tender nodules and plaques on the
shins and ankles for 6 months. Skin biopsy confirmed the diagnosis of EED. Treatment with dapsone resulted in complete resolution
of the skin lesions. EED is rarely reported in SLE, and its presentation and treatment is reviewed. 相似文献
146.
147.
Nobiletin,a Polymethoxylated Flavone,Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways
下载免费PDF全文
![点击此处可从《Phytotherapy research : PTR》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Ray‐Jade Chen Hou‐Chang Chiu Jia‐Lun Wu Ming‐Yi Shen Duen‐Suey Chou Joen‐Rong Sheu Kuan‐Hung Lin Wan‐Jung Lu 《Phytotherapy research : PTR》2016,30(2):214-221
Nobiletin, a bioactive polymethoxylated flavone (5,6,7,8,3',4'‐hexamethoxyflavone), is abundant in citrus fruit peel. Although nobiletin exhibits antitumor activity against various cancer cells, the effect of nobiletin on glioma cells remains unclear. The aim of this study was to determine the effects of nobiletin on the human U87 and Hs683 glioma cell lines. Treating glioma cells with nobiletin (20–100 µm ) reduced cell viability and arrested the cell cycle in the G0/G1 phase, as detected using a 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay and propidium iodide (PI) staining, respectively; however, nobiletin did not induce cell apoptosis according to PI‐annexin V double staining. Data from western blotting showed that nobiletin significantly attenuated the expression of cyclin D1, cyclin‐dependent kinase 2, cyclin‐dependent kinase 4, and E2 promoter‐binding factor 1 (E2F1) and the phosphorylation of Akt/protein kinase B and mitogen‐activated protein kinases, including p38, extracellular signal‐regulated kinase, and c‐Jun N‐terminal kinase. Our data also showed that nobiletin inhibited glioma cell migration, as detected by both functional wound healing and transwell migration assays. Altogether, the present results suggest that nobiletin inhibits mitogen‐activated protein kinase and Akt/protein kinase B pathways and downregulates positive regulators of the cell cycle, leading to subsequent suppression of glioma cell proliferation and migration. Our findings evidence that nobiletin may have potential for treating glioblastoma multiforme. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
148.
149.
150.