全文获取类型
收费全文 | 267篇 |
免费 | 18篇 |
专业分类
儿科学 | 16篇 |
妇产科学 | 19篇 |
基础医学 | 29篇 |
口腔科学 | 11篇 |
临床医学 | 18篇 |
内科学 | 56篇 |
皮肤病学 | 5篇 |
神经病学 | 21篇 |
特种医学 | 2篇 |
外科学 | 17篇 |
综合类 | 12篇 |
预防医学 | 15篇 |
眼科学 | 15篇 |
药学 | 42篇 |
中国医学 | 1篇 |
肿瘤学 | 6篇 |
出版年
2023年 | 1篇 |
2022年 | 9篇 |
2021年 | 17篇 |
2020年 | 11篇 |
2019年 | 7篇 |
2018年 | 15篇 |
2017年 | 8篇 |
2016年 | 8篇 |
2015年 | 13篇 |
2014年 | 16篇 |
2013年 | 23篇 |
2012年 | 26篇 |
2011年 | 19篇 |
2010年 | 12篇 |
2009年 | 9篇 |
2008年 | 15篇 |
2007年 | 15篇 |
2006年 | 14篇 |
2005年 | 7篇 |
2004年 | 11篇 |
2003年 | 8篇 |
2002年 | 8篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1984年 | 1篇 |
1978年 | 1篇 |
1975年 | 1篇 |
排序方式: 共有285条查询结果,搜索用时 15 毫秒
71.
Nouf N. Mahmoud Haneen Qabooq Shrouq Alsotari Ola A. Tarawneh Nour H. Aboalhaija Sawsan Shraim Alaaldin M. Alkilany Enam A. Khalil Rana Abu-Dahab 《RSC advances》2021,11(33):19956
Herein, a polymeric nanofiber scaffold loaded with Quercetin (Quer)–gold nanorods (GNR) was developed and characterized. Several parameters related to loading Quer into GNR, incorporating the GNR-Quer into polymeric solutions, and fabricating the nanofibers by electrospinning were optimized. GNR-Quer loaded into a polymeric mixture of poly(lactic-co-glycolic acid) (PLGA) (21%) and poloxamer 407 (23%) has produced intact GNR-Quer-nanofibers with enhanced physical and mechanical properties. GNR-Quer-nanofibers demonstrated a slow pattern of Quer release over time compared to nanofibers free of GNR-Quer. Dynamic mechanical thermal analysis (DMTA) revealed enhanced uniformity and homogeneity of the GNR-Quer-nanofibers. GNR-Quer-nanofibers demonstrated a high ability to retain water upon incubation in phosphate buffer saline (PBS) for 24 h compared to nanofibers free of GNR-Quer. A cellular toxicity study indicated that the average cellular viability of human dermal fibroblasts was 76% after 24 h of exposure to the nanofibers containing a low concentration of GNR-Quer.Incorporating GNR-Quer into a mixture of 21% PLGA LMWT and 23% poloxamer 407 produced smooth, intact and uniform electrospun nanofibers with enhanced mechanical properties and hydration potential. 相似文献
72.
Sawsan M. Kalache Benoit H. Mulsant Simon J. C. Davies Angela Y. Liu Aristotle N. Voineskos Meryl A. Butters Dielle Miranda Mahesh Menon Robert S. Kern Tarek K. Rajji 《Schizophrenia bulletin》2015,41(2):374-381
Objective: Life expectancy in individuals with schizophrenia continues to increase. It is not clear whether cognitive deficits associated with schizophrenia remain as strong predictors of function in older and younger individuals. Thus, we assessed the relationship between cognition and functional competence in individuals with schizophrenia across 7 decades of life. Methods: We analyzed data obtained in 232 community-dwelling participants with schizophrenia (age range: 19–79 years). Cognition was assessed using the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery. Functional competence was assessed using the UCSD Performance-based Skills Assessment, which includes measures of Comprehension and Planning of Recreational Activities Skills, Financial Skills, Communication Skills, Transportation Skills, and Household Management Skills. To assess the effects of Global Cognition on functional competence, we performed hierarchical multivariate linear or logistic regression analyses controlling for age, education, gender, and negative symptoms. Results: Participants’ mean age was 49.1 (SD = 13.2, range = 19–79 years), 161 (69%) were male, and 55 (24%) were aged ≥60. Global Cognition was a predictor of Comprehension and Planning Skills (Exp(β) = 1.048), Financial Skills (Exp(β) = 1.104), Communication Skills (ΔR
2 = .31) and Transportation Skills (Exp(β) = 1.066), but not Household Management Skills after adjusting for age, education, gender, and negative symptoms of schizophrenia. Conclusion: Cognition remains a strong predictor of functional competence across the lifespan. These findings suggest that treating cognitive impairment associated with schizophrenia could improve individuals’ function independent of their age.Key words: aging, cognition, functional, competence, lifespan, schizophrenia 相似文献
73.
This paper explores the beliefs of a rural population in the Sudan in relation to the causes of oral diseases and their attitudes towards traditional healers and treatments. Qualitative methods, using ethnography and narrative, explored people's experiences. The study identifies conflicting narratives concerning oral health with coherent cultural beliefs and attitudes appearing to underpin oral health related behaviours. 相似文献
74.
Peroxisome proliferator–activated receptor (PPAR)α expression in T cells mediates gender differences in development of T cell–mediated autoimmunity
下载免费PDF全文
![点击此处可从《The Journal of experimental medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
75.
Orchidee H. Hishmat Hoda I. El-Diwani Sherifa M. A. Bakr Sawsan S. Mahmoud Somaya A. Nada 《Archives of pharmacal research》1993,16(2):168-174
The michael adducts2a,b were obtained from the reaction of the phenylacetyl derivative1 with benzaldehyde and p-anisaldehyde respectively.2a and2b were subjected to react with cyanoethanoic acid hydrazide, malononitrile, cyanothioacetamide, cyanoacetamide and 1,1,3-tricyano-2-amino
propene to yield4a-h and5a,b respectively. Hydrogen peroxide oxidation of2a,b gave the aurone derivative6a,b. The pyrone derivatives8a,b were obtained from2a,b by addition of chloroacetyl chloride followed by dehydrochlorination. 相似文献
76.
77.
Azab ME Bishara SA Ramzy RM Oteifa NM El-Hoseiny LM Ahmed MA 《Parasitology research》2004,92(6):473-477
This is the first study dealing with the correlation between HLA antigens and cystic echinococcosis (CE) in Egyptian patients. The potential immunogenetic predisposition for susceptibility and resistance to unilocular echinococcosis was investigated by HLA-DRB1 typing; first by HLA-DRB1 amplification using PCR then using the allele-specific probing technique based on the reverse hybridization principle. The study was carried out on 35 patients with confirmed CE, and 100 apparently healthy individuals. A statistically significant positive association was found between HLA-DR3 and HLA-DR11 and the occurrence of CE. HLA-DR3 antigen was positively associated with the occurrence of isolated pulmonary cysts, multiple cysts, cysts >5 cm in size, non-cured disease and with a common radiological picture of hydatid cyst. A significant positive association of HLA-DR11 with the occurrence of cysts <5 cm in size was detected. This study demonstrates that carriers of DR-3 and DR-11 are at high risk for CE, and that those with DR-3 are more liable to complications. 相似文献
78.
This work provides substantial evidence for the advocated diuretic effect of parsley in folk medicine and determines the mechanism of action of the herb. Rats offered an aqueous parsley seed extract to drink, eliminated a significantly larger volume of urine per 24 h as compared to when they were drinking water. These findings were supported by the results of other experiments using an in situ kidney perfusion technique which demonstrated also a significant increase in urine flow rate with parsley seed extract. This effect was still apparent in presence of amiloride, furosemide and in the absence of sodium, but not in the absence of potassium, suggesting that the diuretic effect of the herb is mediated through an increase in K+ retention in the lumen. Parsley extract, was shown on the other hand, to reduce the activity of the Na+-K+ ATPase in both cortex and medulla homogenates. Such an inhibition would decrease apical cellular Na+ reabsorption, lower K+ secretion, increase K+ concentration in the intercellular space and consequently would inhibit passive K+ influx across the tight junctions. The mechanism of action of parsley seems to be mediated through an inhibition of the Na+-K+ pump that would lead to a reduction in Na+ and K+ reabsorption leading thus to an osmotic water flow into the lumen, and diuresis. 相似文献
79.
80.