全文获取类型
收费全文 | 334篇 |
免费 | 27篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 20篇 |
妇产科学 | 4篇 |
基础医学 | 92篇 |
口腔科学 | 5篇 |
临床医学 | 20篇 |
内科学 | 53篇 |
皮肤病学 | 1篇 |
神经病学 | 18篇 |
特种医学 | 50篇 |
外科学 | 25篇 |
综合类 | 2篇 |
预防医学 | 20篇 |
眼科学 | 5篇 |
药学 | 31篇 |
肿瘤学 | 16篇 |
出版年
2023年 | 1篇 |
2021年 | 3篇 |
2020年 | 1篇 |
2019年 | 5篇 |
2018年 | 3篇 |
2017年 | 6篇 |
2016年 | 5篇 |
2015年 | 4篇 |
2014年 | 8篇 |
2013年 | 5篇 |
2012年 | 15篇 |
2011年 | 12篇 |
2010年 | 18篇 |
2009年 | 14篇 |
2008年 | 11篇 |
2007年 | 25篇 |
2006年 | 19篇 |
2005年 | 16篇 |
2004年 | 6篇 |
2003年 | 14篇 |
2002年 | 8篇 |
2001年 | 8篇 |
2000年 | 6篇 |
1999年 | 8篇 |
1998年 | 9篇 |
1997年 | 9篇 |
1996年 | 15篇 |
1995年 | 17篇 |
1994年 | 5篇 |
1993年 | 9篇 |
1992年 | 8篇 |
1991年 | 9篇 |
1990年 | 6篇 |
1989年 | 10篇 |
1988年 | 8篇 |
1987年 | 4篇 |
1986年 | 7篇 |
1985年 | 5篇 |
1984年 | 2篇 |
1982年 | 6篇 |
1981年 | 3篇 |
1980年 | 7篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 2篇 |
排序方式: 共有368条查询结果,搜索用时 15 毫秒
31.
颜光涛 《军医进修学院学报》2010,31(1):1-3,38
对瘦素与肿瘤的最新研究进展进行综述,并阐明瘦素参与调节肿瘤发生、发展的可能机制,它可能有望成为早期诊治肿瘤的一个关键点。 相似文献
32.
33.
Chalmers RM; Howard RS; Wiles CM; Hirsch NP; Miller DH; Williams A; Spencer GT 《QJM : monthly journal of the Association of Physicians》1996,89(6):469-476
Twenty-nine patients with a neuronopathic or neuropathic disorder were
referred for assessment of respiratory insufficiency between 1978 and 1994.
Diagnoses included spinal muscular atrophy (6), chronic idiopathic
demyelinating neuropathy (4), Vialetto-van Laere syndrome (3), hereditary
motor and sensory neuropathy (3) and a miscellaneous group (5). We also
describe seven patients with Guillain-Barre syndrome (GBS) who required
long-term ventilatory support for over 6 months to 7 years after the
initial illness. Respiratory insufficiency occurred as a consequence of
respiratory muscle weakness, impaired bulbar function and restrictive lung
defects. In some groups presentation was with progressive nocturnal
hypoventilation culminating in acute respiratory failure. Five patients
with GBS or chronic idiopathic demyelinating neuropathy were weaned from
ventilatory support up to 18 months after the initial illness. The
remaining 24 patients required continuous or nocturnal ventilatory support
using intermittent positive-pressure ventilation (13), negative pressure
ventilation (4), nasal-mask-delivered intermittent positive-pressure
ventilation (4), nasal-mask-delivered continuous positive-pressure
ventilation (3), mouthpiece-assisted ventilation by day (2) and rocking bed
(1). None have been weaned from support after a period of ventilation
ranging from one month to 10 years. Eight patients have subsequently died.
相似文献
34.
L. Chambers A. Avery J. Dalrymple L. Farrell G. Gibson J. Harrington G. Rijkers I. Rowland A. Spiro G. Varela‐Moreiras L. Vokes L. Younge K. Whelan S. Stanner 《Nutrition Bulletin》2019,44(2):165-173
Scientific and clinical evidence on the health effects of probiotics has expanded rapidly in recent years and points towards benefits for a number of specific health conditions, particularly those related to the gut. Healthcare professionals are important conduits in the transfer of evidence‐based messages on probiotics, but research indicates many do not consider themselves to have good knowledge in this area. To identify potential solutions to support healthcare professionals, the British Nutrition Foundation held a one‐day roundtable event on 7 February 2019 to gather expert views on the content of, and best delivery mode for, evidence‐based resources to guide healthcare professional advice about the use of probiotics. This report describes the main themes emerging from the discussions and the group's recommendation for the development of a UK‐focused online toolkit for healthcare professionals, which assimilates, appraises and translates current scientific knowledge of probiotics to promote evidence‐based practice for the benefit of patients. 相似文献
35.
36.
L. Niers R. Martín G. Rijkers F. Sengers H. Timmerman N. van Uden H. Smidt J. Kimpen M. Hoekstra 《Allergy》2009,64(9):1349-1358
Background: Modification of the intestinal microbiota by administration of probiotic bacteria may be a potential approach to prevent allergic disease. We aimed to study primary prevention of allergic disease in high-risk children by pre- and postnatal supplementation of selected probiotic bacteria.
Methods: In a double-blind, randomized, placebo-controlled trial, a mixture of probiotic bacteria selected by in-vitro experiments ( Bifidobacterium bifidum, Bifidobacterium lactis, and Lactococcus lactis ; Ecologic® Panda) was prenatally administered to mothers of high-risk children (i.e. positive family history of allergic disease) and to their offspring for the first 12 months of life.
Results: Parental-reported eczema during the first 3 months of life was significantly lower in the intervention group compared with placebo, 6/50 vs 15/52 ( P = 0.035). After 3 months, the incidence of eczema was similar in both groups. Cumulative incidence of parental-reported eczema at 1 and 2 years was 23/50 (intervention) vs 31/48 (placebo) and 27 (intervention) vs 34 (placebo), respectively. The number needed to treat was 5.9 at age 3 and 12 months and 6.7 at age 2 years. The intervention group was significantly more frequently colonized with higher numbers of Lc. lactis. Furthermore, at age 3 months, in vitro production of IL-5 (146 pg/ml vs 72 pg/ml; P = 0.04) was decreased in the probiotic-group compared with the placebo-group.
Conclusions: This particular combination of probiotic bacteria shows a preventive effect on the incidence of eczema in high-risk children, which seems to be sustained during the first 2 years of life. In addition to previous studies, the preventive effect appears to be established within the first 3 months of life. 相似文献
Methods: In a double-blind, randomized, placebo-controlled trial, a mixture of probiotic bacteria selected by in-vitro experiments ( Bifidobacterium bifidum, Bifidobacterium lactis, and Lactococcus lactis ; Ecologic
Results: Parental-reported eczema during the first 3 months of life was significantly lower in the intervention group compared with placebo, 6/50 vs 15/52 ( P = 0.035). After 3 months, the incidence of eczema was similar in both groups. Cumulative incidence of parental-reported eczema at 1 and 2 years was 23/50 (intervention) vs 31/48 (placebo) and 27 (intervention) vs 34 (placebo), respectively. The number needed to treat was 5.9 at age 3 and 12 months and 6.7 at age 2 years. The intervention group was significantly more frequently colonized with higher numbers of Lc. lactis. Furthermore, at age 3 months, in vitro production of IL-5 (146 pg/ml vs 72 pg/ml; P = 0.04) was decreased in the probiotic-group compared with the placebo-group.
Conclusions: This particular combination of probiotic bacteria shows a preventive effect on the incidence of eczema in high-risk children, which seems to be sustained during the first 2 years of life. In addition to previous studies, the preventive effect appears to be established within the first 3 months of life. 相似文献
37.
J. Neil Waddell MDipTech PGDipCDTech HDE ; Alan GT Payne BDS MDent DDSc FCD ; Michael V. Swain BSc PhD ; Jules A. Kieser BDS PhD DSc FLS FDSRCSEd 《Clinical implant dentistry and related research》2010,12(1):26-38
Background: Soldered or cast bars are used as a standard of care in attachment systems supporting maxillary and mandibular implant overdentures. When failures of these bars occur, currently there is a lack of evidence in relation to their specific etiology, location, or nature. Purpose: To investigate the failure process of a case series of six failed soldered bars, four intact soldered bars, and one intact cast milled bar, which had been supporting implant overdentures. Materials and Methods: A total of 11 different overdenture bars were removed from patients with different configuration of opposing arches. A failed bar (FB) group (n = 6) had failed soldered overdenture bars, which were recovered from patients following up to 2 years of wear before requiring prosthodontic maintenance and repair. An intact bar (IB) group (n = 5) had both soldered bars and a single cast milled bar, which had been worn by patients for 2 to 5 years prior to receiving other aspects of prosthodontic maintenance. All bars were examined using scanning electron microscopy to establish the possible mode of failure (FB) or to identify evidence of potential failure in the future (IB). Results: Evidence of a progressive failure mode of corrosion fatigue and creep were observed on all the FB and IB usually around the solder areas and nonoxidizing gold cylinder. Fatigue and creep were also observed in all the IB. Where the level of corrosion was substantial, there was no evidence of wear from the matrices of the attachment system. Evidence of an instantaneous failure mode, ductile and brittle overload, was observed on the fracture surfaces of all the FB, within the solder and the nonoxidizing gold cylinders, at the solder/cylinder interface. Conclusion: Corrosion, followed by corrosion fatigue, appears to be a key factor in the onset of the failure process for overdenture bars in this case series of both maxillary and mandibular overdentures. Limited sample size and lack of standardization identify trends only but prevent broad interpretation of the findings. 相似文献
38.
Rijkers K van Aalst J Kurt E Daemen MA Beuls EA Spincemaille GH 《Journal of neurosurgery》2009,110(2):274-278
The authors present the case of a 49-year-old female patient with complex regional pain syndrome-Type I (CRPSI) who was suffering from nonhealing wounds and giant bullae, which dramatically improved after spinal cord stimulation (SCS). The scientific literature concerning severe cutaneous manifestations of CRPS-I and their treatment is reviewed. Nonhealing wounds and bullae are rare manifestations of CRPS-I that are extremely difficult to treat. Immediate improvement of both wounds and bullae after SCS, such as in this case, has not been reported previously in literature. Considering the rapidly progressive nature of these severe skin manifestations, immediate treatment, possibly with SCS, is mandatory. 相似文献
39.
40.
Robotics in otolaryngology and head and neck surgery: Recommendations for training and credentialing: A report of the 2015 AHNS education committee,AAO‐HNS robotic task force and AAO‐HNS sleep disorders committee 下载免费PDF全文
Neil D. Gross MD F. Christopher Holsinger MD J. Scott Magnuson MD Umamaheswar Duvvuri MD PhD Eric M. Genden MD Tamer AH. Ghanem MD PhD Kathleen L. Yaremchuk MD David Goldenberg MD Matthew C. Miller MD Eric J. Moore MD Luc GT. Morris MD James Netterville Gregory S. Weinstein MD Jeremy Richmon MD 《Head & neck》2016,38(Z1):E151-E158