^125I（±）心得静的制备及其与小鼠肺,脑β受体的结合特性

用氯胺-T氧化法制备[125Ⅰ]-心得静(125Ⅰ-IPIN)为探针,研究其与小鼠脑、肺组织β-肾上腺素能受体(β-adrenergic receptor,β-AR)的结合特性。平衡结合试验、结合解离动力学试验及竞争抑制试验结果表明:125Ⅰ-IPIN与上述组织β-AR的结合具有可饱和性、可逆性和特异性。其平衡解离常数(KD)为0.143±0.042nM(脑,n=14),0.180±0.072nM(肺,n=13);最大结合容量(Bmax)为37.04±6.68 fmol/mg蛋白(脑),370.05±86.36 fmol/mg蛋白(肺);Hill系数接近1.当配基浓度在0.01～0.3nM的范围内。Scatchard分析呈一直线。     

胫,股骨内压与膝关节疼痛关系的研究和治疗方法探讨

作者对膝关节痛和休息痛病人21例做了股、胫骨内压和关节镜检查,其均值股骨髁0.143±0.01kPa,16例(76.19％)超过对照组0.130kPa(P<0.01);胫骨髁0.180±0.022kPa,18例(85.7％),超过对照组0.105kPa。同时测量膝关节腔内压21例。均值为0.135±0.035kPa,18例(85.7％)高于对照组0.120kPa。认为骨内压增高是引起膝关节痛的原因。本文还就膝关节特发性骨内高压症的临床表现、镜下特点、个体临界骨内压和治疗方法进行了探讨。     

1,6—二磷酸果糖对手术后应激病人应用全肠外营养支持效果的影响

本文在胃癌行全胃或胃大部切除术引起的中等程度应激病人，随机分组对比观察了全肠外营养或ＴＰＮ加用１，６－二磷酸果糖的效果。结果显示，与单纯ＴＰＮ相比，ＴＰＮ加用ＦＤＰ后血清皮质醇和胰高血糖素等应激激素水平有所下降，尿中３－甲基组氨酸排出减少，累积氮平衡增加。     

Posterior Cervical-Thoracic Thermograms: Pattern Persistence and Correlation with Chronic Headache Syndromes

SYNOPSIS
These experiments investigate thermographic patterns in the posterior cervical/thoracic (PCT) region of 530headache patients and 30 headache/injury-free volunteers. The study examines: The longitudinal persistence ofProximal and Distal patterns; three distinct midline patterns (PCT I, II, and III); and their correlation with diagnosis,injury, and pain.
Twenty-four (80%) of 30 randomly selected subjects displayed unchanged Proximal patterns at the meanobservation period of 5.5 months. PCT pattern fluctuations occurred in 13/30 (43.3%) subjects. The distinctivenessof each subject's Proximal and Distal patterns was verified by blind calling of thermogram pairs. Patternpersistence was validated with alcohol spray-Patterns were identical regardless of using a 0.5°C or 1.0°Ctemperature setting. Temperature settings of 1.0°C yielded more distinct Proximal and Distal patterns.
Chi square analysis determined that there was no significant difference in the number of PCT III patterns in theexperimental or control groups.
In conclusion, it appears that Proximal and Distal Patterns may be consistent over time and individually unique,but that PCT patterns fluctuate and, therefore, do not correlate with chronic headaches.