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Pasquale Spataro Angela Di Pietro Maria Elena Scoglio Giuseppa Visalli Cristina Chirico Isa Picerno 《Renal failure》2013,35(5):441-448
Introduction. Recently, the identification of the SEN virus as a possible etiological agent of parental transmission hepatitis led to the study of the prevalence of such pathogen agents, particularly SENV-H, in our population. This paper compares the rate prevalence in high-risk subjects, such as dialysis patients, and low-risk subjects, such as blood donors. Material and Methods. The study was carried out on SEN virus DNA extracted from serum of dialysis patients and blood donors, and the presence of viral genomes was performed by the nested PCR method. Results. The results showed a higher prevalence in male blood donors, supporting the hypothesis of an epidemiological role for sexual and also parental transmission, as is clearly demonstrated by the high prevalence in dialysis patients. The result reduced the importance of the possible etiological role of the SEN virus due to the high percentage of positivity in healthy population, and it induces one to consider poorly significant the pathogenicity of such viral agents. Conclusion. For this instance, the authors, in agreement with the phylogenically related TT virus, described SEN viruses as absolutely not pathogens and considered them as “simple guests.” 相似文献
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Antonino Di Franco Filippo M. Sarullo Ylenia Salerno Stefano Figliozzi Rossella Parrinello Pietro Di Pasquale Gaetano A. Lanza 《Am J Cardiovasc Drugs》2014,14(2):101-110
Beta-blockers have become one of the cornerstones of treatment of patients with heart failure (HF) and depressed left ventricular function, but in clinical practice only 30–35 % of patients achieve the therapeutic target dose as established in randomized clinical trials. Moreover, high resting heart rate (HR) has emerged as a simple but relevant risk factor for cardiovascular events, including coronary artery disease and HF; also, it was found to have an independent prognostic value in patients with HF. Evidence that HR could be considered a good parameter to evaluate the quality of treatment in patients with HF has been suggested; of note, many patients maintain a resting HR ≥70 beats per minute despite optimal beta-blocker therapy. In recent years, a new drug able to reduce HR, ivabradine, has been introduced in clinical practice, and its use in the clinical setting of HF patients has been recommended by current European Society of Cardiology (ESC) guidelines. Here we review the evidence of the prognostic role of HR in systolic HF and the potential relationship between HR lowering and the beneficial effects of beta-blockers; we will also analyze the reasons why an appropriate use of these drugs is seldom achieved in clinical practice, and review the evidence for the use of ivabradine in systolic HF in the clinical setting. 相似文献
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Primary care nursing activities with patients affected by physical chronic disease and common mental disorders: a qualitative descriptive study
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A Dedicated Nutritional Care Program (NUTRICARE) to reduce malnutrition in institutionalised dysphagic older people: A quasi‐experimental study
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Milko Zanini PhD MSN MSoc Annamaria Bagnasco PhD Gianluca Catania PhD MSN RN Giuseppe Aleo PhD MA Marina Sartini BSC PhD Maria Luisa Cristina MSc MNatSc Stefania Ripamonti MSBiol Fiammetta Monacelli PhD MD Patrizio Odetti MD Loredana Sasso MSN FAAN 《Journal of clinical nursing》2017,26(23-24):4446-4455