全文获取类型
收费全文 | 746篇 |
免费 | 54篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 28篇 |
妇产科学 | 8篇 |
基础医学 | 95篇 |
口腔科学 | 4篇 |
临床医学 | 42篇 |
内科学 | 250篇 |
皮肤病学 | 18篇 |
神经病学 | 38篇 |
特种医学 | 11篇 |
外科学 | 89篇 |
综合类 | 39篇 |
预防医学 | 43篇 |
眼科学 | 12篇 |
药学 | 71篇 |
中国医学 | 2篇 |
肿瘤学 | 46篇 |
出版年
2023年 | 4篇 |
2022年 | 8篇 |
2021年 | 21篇 |
2020年 | 9篇 |
2019年 | 7篇 |
2018年 | 8篇 |
2017年 | 11篇 |
2016年 | 11篇 |
2015年 | 12篇 |
2014年 | 14篇 |
2013年 | 25篇 |
2012年 | 35篇 |
2011年 | 45篇 |
2010年 | 19篇 |
2009年 | 17篇 |
2008年 | 40篇 |
2007年 | 27篇 |
2006年 | 34篇 |
2005年 | 32篇 |
2004年 | 22篇 |
2003年 | 28篇 |
2002年 | 28篇 |
2001年 | 23篇 |
2000年 | 24篇 |
1999年 | 23篇 |
1998年 | 14篇 |
1996年 | 12篇 |
1995年 | 7篇 |
1994年 | 7篇 |
1993年 | 4篇 |
1992年 | 30篇 |
1991年 | 28篇 |
1990年 | 21篇 |
1989年 | 8篇 |
1988年 | 12篇 |
1987年 | 11篇 |
1985年 | 14篇 |
1984年 | 12篇 |
1983年 | 8篇 |
1981年 | 3篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1975年 | 3篇 |
1974年 | 5篇 |
1972年 | 12篇 |
1971年 | 5篇 |
1970年 | 7篇 |
1969年 | 9篇 |
1967年 | 10篇 |
1966年 | 5篇 |
排序方式: 共有802条查询结果,搜索用时 15 毫秒
21.
Prashant Pandey Divya Setya Amit K. Devra Vijay Kumar Sinha Anil Prasad Bhatt Amit Pande Praveen Kumar Mukesh Kumar Singh Shweta Ranjan 《Transfusion and apheresis science》2021,60(1):102954
Background and aimsPreconditioning using different protocols has been tested to prevent antibody mediated rejection (ABMR) individually for ABO and HLA incompatibility. However, simultaneous presence of both barriers is still less explored. The aim of this study was to report outcomes of institutional desensitization protocol in renal transplant recipients with simultaneous ABO and HLA incompatibility.Materials and methodsThis was a retrospective study conducted from October 2015 to December 2018. All patients with a clinical diagnosis of dialysis dependent chronic kidney disease (CKD), who were prospective coexistent HLA and ABO incompatible renal transplant recipients were included in the study. Patients were followed up and graft function and patient survival was assessed at 1 y from the date of transplant.ResultsMedian and mode baseline anti-A titers were 64, while median and mode baseline anti-B titers were 256. All recipients were discharged by tenth postoperative day. None of the patients had any bleeding complications. Post transplant infection rate was found to be 20 %. A total of 54 therapeutic plasma exchange (TPE) procedures were performed before transplant and 8 were performed after transplant. Graft survival and patient survival was 100 % at 3, 6, 9, and 12 months. Range and mean follow-up period was 15–42 months and 23 months respectively. Mean glomerular filtration rate (GFR) at 1 y using the CKD-EPI equation was 85.25 ± 13.76 mL/min. Biopsy proven ABMR was observed in one case only which was managed with TPE and immunosuppression.ConclusionSimultaneous ABO and HLA incompatibility in renal transplant recipients can be managed successfully with adequate preconditioning and careful monitoring. 相似文献
22.
F de la Serna B Meier A K Pande P Urban J J Adatte V P Moles J P Killisch J J Bodenmann G Barcellona P A Dorsaz 《Catheterization and cardiovascular diagnosis》1992,25(4):285-289
Coronary pacing using as unipolar negative electrode a guidewire placed in a coronary branch was tested in 349 sites of 300 consecutive patients undergoing coronary angioplasty. It was possible for 339 sites (97%). The threshold currents ranged from 1 to 15 (mean +/- standard deviation 3.4 +/- 2.4) mA. Side effects were seen in 13 patients (4%): 6 (2%) had transient coronary spasm, 4 (1%) had diaphragmatic stimulation, and 3 (1%) had stinging pain at the skin electrode. Of the 10 cases with pacing failure, left ventricular pacing was successfully tested in 5 by introducing the coronary wire or another wire into the left ventricle. It yielded a threshold of 2-8 (3.2 +/- 2.7) mA. Therapeutic pacing for significant bradycardia was required in 7 patients (2%). It was successful in all. Coronary or left ventricular pacing appears to be a simple and reliable temporary measure. When there is no wire in the coronary artery or for diagnostic catheterization, left ventricular pacing can be done using the same setup and any type of guidewire. 相似文献
23.
Prashant Pandey Divya Setya Vijay Sinha Anil Bhatt Amit Devra Amit Pande Praveen Kumar Shweta Ranjan 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2020,24(5):578-590
Successful renal transplantation across HLA barrier in sensitized individuals has been on the rise during the past decade, primarily due to improved desensitization regimes. The aim of this study was to share outcome of desensitization in renal transplant recipients with donor‐specific anti‐HLA antibodies (DSA). This was a retrospective analysis of all HLA immunized individuals who were prospective renal transplant recipients. All such patients underwent preconditioning as per the institutional desensitization protocol. Complement‐dependent cytoxicity‐based crossmatch (CDC‐XM), luminex‐based crossmatch (LM‐XM) and flowcytometry‐based crossmatch (FC‐XM) were done in all cases. If any of these tests turned out positive, single antigen bead assay (SAB) was performed. Desensitization for DSA was performed in 55 patients and all patients were followed‐up for 1 year to assess graft function and patient outcome. CDC‐XM being a less sensitive assay, could not detect incompatibility in 29 (52.73%) cases. After desensitization, even though SAB and LM‐XM results revealed an MFI within acceptable range, FC‐XM being an extremely sensitive assay, continued to give a positive result in eight (14.55%) cases. The mean ± SD number of pretransplant TPE were 3.44 ± 0.98 (2‐11). Out of 55, there were 10 patients who were lost to follow up. Patient and graft survival of 45 patients at 1 year was found to be 100%. Preconditioning for renal transplants in the form of immunosuppression with TPE is an extremely useful auxiliary for transplantation in HLA sensitized renal transplant recipients. 相似文献
24.
Pande RL 《Current treatment options in cardiovascular medicine》2012,14(2):177-183
Hyperlipidemia increases the incidence of atherosclerotic vascular disease and is associated with greater rates of recurrent
cardiovascular events among individuals with established vascular disease. Several large population studies have confirmed
the link between all cholesterol components (including elevated low-density lipoprotein [LDL] cholesterol, total cholesterol,
and triglyceride levels, and reduced high-density lipoprotein [HDL] levels) with coronary heart disease and other manifestations
of systemic atherosclerosis. In addition, landmark clinical trials have clearly established that lowering LDL cholesterol
levels with statins (HMG-CoA reductase inhibitors) can lower recurrent cardiovascular events by nearly 25%. The benefits of
altering non-LDL cholesterol levels (eg, triglycerides and HDL) are less clear, but several other medications are often used
in conjunction with statins for cholesterol lowering. First-line therapy for lipid lowering in patients with atherosclerotic
vascular disease includes statins and a recommendation for lifestyle changes (including diet and exercise). Second-line options
for lowering cholesterol include fibrates, nicotinic acid, bile acid sequestrants, and ezetimibe. Therapeutic goals for patients
with vascular disease are to achieve an LDL cholesterol level < 100 mg/dL, or <70 mg/dL in individuals at particularly high
risk. 相似文献
25.
26.
Ashish Gupta Harish K. Rao Raghav Pande Soumya Gupta 《The Indian journal of surgery》2013,75(1):27-29
A middle aged housewife presented with an anterior abdominal wall mass which was slowly growing over a period of 1 years over the midline scar of previous caesarean section with cystic degeneration in a part of the tumor. Fine needle aspiration cytology revealed a papillary serous cystadenoma. At exploratory laparotomy tumor was seen arising from the ventral surface of the parietal peritoneum with normal viscera, omentum and ovaries. The pathologist reported the tumor as Benign Multicystic Peritoneal Mesothelioma. It is a rare but clinically favourable neoplasm with wide excision as the definitive treatment. Of the 130 cases reported in the literature, it has the least incidence in the Indian Subcontinent. 相似文献
27.
Aim The national Bowel Cancer Screening Programme has been rolled out nationwide following pilot screening in two health authorities in the UK. The aim of this study was to define overall 5‐year survival of screen detected cancers and to compare the overall survival outcome of screened vs symptomatic patients over a 10‐year period. Method All patients with colorectal cancer treated at one trust in patients of screening age (50–69 years) during the pilot screening programme (2000–2008) were analysed. Patients were defined as screen detected or symptomatically detected. Disease pathology and recurrence data were obtained from the hospital’s computerized results reporting system and mortality was cross‐matched with data from the West Midlands Cancer Intelligence Network. Results In all, 633 patients aged 50–69 were identified in the study period; 155 patients had a screen detected cancer and 478 did not. A log‐rank test completed on survival outcomes indicated that survival was significantly worse in the symptomatic group. This difference persisted if only patients treated with curative intent were considered. Conclusion Survival outcome was significantly better in the screened vs the symptomatic population in all groups and also in those treated for curative intent. There was a trend towards better survival for screen detected cancer when compared stage for stage. 相似文献
28.
Deepti Pande Reena Negi Kanchan Karki Udai S. Dwivedi Ranjana S. Khanna Hari D. Khanna 《Urologic oncology》2013,31(8):1561-1566
ObjectivesTo understand the association between markers of oxidative stress, levels of vascular endothelial growth factor (VEGF), and cell proliferation index in relation to disease progression, clinical stage, and cytologic grade in pathophysiology of prostate carcinoma.Patients and methodsCase control study comprised of 40 prostate carcinoma patients along with 40 age- and sex-matched healthy subjects as controls. Levels of 8-hydroxy-2-deoxy guanosine, protein carbonyl, and malondialdehyde along with total antioxidant status were measured to study the oxidative stress status in the study subjects. Angiogenesis was evaluated by studying the VEGF level and cell proliferation index.ResultsThe levels of markers of oxidative stress along with VEGF and cell proliferation index were found to be significantly higher with significantly decreased levels of antioxidant activity in the study subjects in comparison with healthy controls. The results indicate oxidative stress, angiogenesis, and cell proliferation activity increase progressively with the increase in staging and progression of disease.ConclusionsOxidative stress parameters, angiogenesis, and cell proliferation activity point clearly that with the progression of oxidative stress there is a simultaneous progression of angiogenesis, regulation and control of endothelial cell proliferation in relation to disease progression, clinical stage, and cytologic grade in the pathophysiology of prostate carcinoma. 相似文献
29.
Objective
The purpose of this study is to understand the epidemiology, clinical features, behavior, and the prognostic factors that influence the outcome of intracranial meningiomas in children.Methods
Thirty-one patients with age less than 18 years who underwent surgery for intracranial meningiomas during the period of at 1988–2012 at Voluntary Health Services Hospital, Chennai, India were studied. These formed 3.7 % of the total 831 cases of intracranial meningiomas operated at the institute.Results
The study group included 22 (71 %) males and 9 (29 %) females. The mean age of presentation was 15 years, with the youngest being 9 months old. Two (6 %) had evidence of neurofibromatosis type 2 (NF2). The most common symptoms at presentation were seizures in 11 (35.5 %), weakness of limbs in 11 (35.5 %), and raised intracranial pressure in 10 (32 %). Convexity meningiomas were seen in 16 (51 %) and skull base in 15(49 %). Multiple meningiomas was seen in two (6 %) of the patients and intraventricular location was found in one patient (3 %). Two (6 %) had evidence of NF2. Gross total excision was achieved in 26 (83 %) and subtotal excision in 5 (17 %). WHO grade I was found in 20 (64 %) and higher grade was seen in 11 (36 %). The mean follow-up was 46.2 months. Recurrence was seen in 20 patients (64 %). In patients with higher grade or with recurrence resurgery and radiotherapy was given. Three (9 %) had multiple recurrences. On a mean follow-up of 46.2 months, 25 patients (81 %) were neurologically intact, 5 (16 %) were having moderated disability, and 1 (3 %) patient died.Conclusions
Childhood meningiomas are uncommon lesions with a slight male predominance. They can have a varied clinical presentation. Higher grade is found more frequently compared with adults. Gross total resection is the goal and in higher grade meningiomas radiotherapy helps as a good adjuvant. Though the rate of recurrence is high, resurgery and radiotherapy gives a good outcome. 相似文献30.
Synergistic Combination for Chemoprevention of Hepatocellular Carcinoma: An In Silico and In Vitro Approach 下载免费PDF全文
Savita Mishra Deepshikha Pande Katare 《Basic & clinical pharmacology & toxicology》2017,120(6):532-540
Combination therapy is one of the best methods to manage the fatality rate in hepatocellular carcinoma (HCC). This study aimed to formulate a synergistic combination of synthetic and herbal compounds for the treatment of HCC as well as to elucidate a possible signalling mechanism. MTT and enzymatic assay were performed to determine the synergistic effect of drug combination (sorafenib, vitamin K1 and trans‐chalcone) on HepG2 cell lines after intoxication with H2O2. Protein–protein interaction and docking studies were performed using Pathwaylinker2.0 and Schrödinger's software application to find out the mechanism of action and major targets for drug combination. The overall in vitro result showed that combination of trans‐chalcone, vitamin K1 and sorafenib (10, 5 and 5 μM concentration, respectively) enhanced the resistance against oxidative stress generated by H2O2. The interaction studies helped in identification of few targets for docking of ligands (trans‐chalcone, vitamin K1 and sorafenib). The study reports the synergistic effects of the formulation that can protect the cells from oxidative stress and restore normal levels of cellular enzymes in HepG2 cell line. We were able to determine the mechanism of action of herbal and synthetic formulation through in silico studies. Finally, docking studies confirmed potential targets for inhibition of hepatocarcinogenesis. 相似文献