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301.
Recombinant immunoblot assay reaction patterns and hepatitis C virus RNA in blood donors and non-A, non-B hepatitis patients 总被引:5,自引:0,他引:5
D Bresters ; HL Zaaijer ; HT Cuypers ; HW Reesink ; IN Winkel ; PJ van Exel-Oehlers; AA van Drimmelen; PL Jansen ; CL van der Poel; PN Lelie 《Transfusion》1993,33(8):634-638
To establish the value of the second-generation recombinant immunoblot assay (RIBA-2) and cDNA polymerase chain reaction (cDNA PCR) for confirmation of hepatitis C virus (HCV) infection, anti-HCV reaction patterns and the presence of HCV RNA were examined in 610 blood donors and 255 non-A, non-B hepatitis patients who were positive or indeterminate in RIBA-2. Of RIBA-2-positive donors (n = 191) and patients (n = 224), 75.4 and 89.7 percent, respectively, were HCV RNA positive. The most frequently observed anti-HCV recognition patterns in HCV RNA-positive donors and patients were c22, c33c, and c100 and/or 5- 1-1 (67.3%, 57.7%) and c22, c33c (24.8%, 29.3%). Among subjects with a RIBA-2-indeterminate result, HCV RNA was detected more often in patients (n = 31) than in donors (n = 419): 67.7 and 2.1 percent, respectively. In viremic persons with single-band reactivity in RIBA-2, this reactivity was always directed against either c22 or c33c. HCV RNA was detected by cDNA PCR in none of 162 persons with only anti-c100 and/or anti-5-1-1 reactivity. Therefore, RIBA-2 reactivity against c100 in combination with 5-1-1 should not be considered positive but indeterminate. In RIBA-2-indeterminate persons, HCV RNA detection is necessary for reliable confirmation of HCV infection. 相似文献
302.
Onyeka IN Miettola J Ilika AL Vaskilampi T 《African journal of reproductive health》2011,15(2):109-115
This study evaluated efforts of secondary schools to prevent unintended pregnancy among students and their reactions to pregnant students before and after delivery. A cross-sectional survey of 46 teachers in three public and two private schools in Anambra state, Nigeria was carried out. Information was collected using self-administered questionnaire. Of all the teachers in the study, 87% reported unintended pregnancies among students in the previous 3 years. Expulsion (43%) and suspension (28%) were the most common reactions. Private schools were more likely to expel pregnant students than public schools. Following the delivery of their babies, 43% discontinued their education in the same school, whereas 37% continued their education in a different school. Counselling was given before suspension or expulsion in 4% of public schools and 15% of private schools. Majority of the schools (61%) did not have sex education as part of their schools' curriculum. Students should be re-admitted in order to ensure continuity of their academic development, prevent unemployment and mitigate poverty-induced repeat pregnancy. 相似文献
303.
目的:探讨单用雷贝拉唑与法莫替丁联合莫沙必利治疗胃食管反流病的临床效果。方法选取2008年3月~2011年7月本院收治的胃食管反流病患者120例,随机分为治疗组和对照组各60例,治疗组应用雷贝拉唑进行治疗,1~4周口服雷贝拉唑20 mg,1次/d,5~12周改为隔日一次维持治疗;对照组应用法莫替丁进行治疗,1~4周用法莫替丁20 mg,2次/d,加莫沙必利5 mg,3次/d口服,5~12周维持用药则单用法莫替丁20 mg,2次/d。治疗第1、4、8、12周返院就诊,了解患者症状好转程度,第12周对原有食管炎者进行内镜检查以了解食管炎治愈情况。结果治疗组临床症状缓解率及食管炎治愈率明显高于对照组,差异有统计学意义(P<0.05)。结论与法莫替丁加莫沙必利相比,雷贝拉唑治疗胃食管反流病具有临床症状缓解快速、完全缓解率高的优势。 相似文献
304.
国内康复医学相关资源网站综合评估与分析 总被引:5,自引:0,他引:5
目的:探讨网络技术在康复医学资源共享领域的运用。方法:收集近五年来国内有代表性的康复医学资源网站或网络技术,按照各自属性分为学术组织类、专职机构类、特色康复医疗专业类、个体类四组,从一般普通网站共有的特征以及与康复医学资源共享相关的指标两方面进行了分析和比较。结果:所有网站在一般的总体性能指标上差异并不明显,但在与资源共享相关的指标评测中,各类网站总体差异很大。结论:网络技术在康复医学资源共享领域的应用正处于发展阶段,诸多方面尚须深人探究,但将有限的资源最大化共享对推动康复医学事业的整体发展将起到难以估量的作用。 相似文献
305.
Demet YALIN KEHRBAR Metin
ZGEN Servet YOLBA Ahmet YILDIRIM Nee BAAK TÜRKMEN Ebru
NALAN ETEM Osman FT brahim Hanifi
ZERCAN Süleyman Serdar KOCA 《Turkish Journal of Medical Sciences》2021,51(4):2142
Background/aimThe purpose of this study was to investigate the antiarthritic potentials of the inhibition of Src kinase in vivo and in vitro settings. Materials and methodsArthritis was induced by intradermal injection of chicken type II collagen combined with incomplete Freund’s adjuvant (collagen induced arthritis [CIA] model) in Wistar albino rats. One day after the onset of arthritis, dasatinib, a potent Src kinase inhibitor, (5 mg/kg/day) was given via oral gavage. Tissue Src, Fyn, MAPK and STAT mRNA expressions were determined by real-time polymerase chain reaction. On the other hand, fibroblast like synoviocytes (FLSs) were harvested patients with rheumatoid arthritis (RA) undergoing surgical knee joint replacement. FLSs were stimulated with cytokines and dasatinib was added in different concentrations. MMP –1, –3, and –13 levels in FLSs culture were determined by ELISA.ResultsThe tissue mRNA expressions of Src, Fyn, MAPK and STATs were increased in the arthritis CIA group compared to the control group. Their mRNA expressions in the CIA + dasatinib group were decreased and similar in the control group. In in vitro setting, MMP –1, –3, and –13 expressions from FLSs induced by IL-1β and TNF-α were increased, while dasatinib suppressed their productions from FLSs.ConclusionThe present study shows that the inhibition of Src kinase has antiarthritic potentials in both in vivo and in vitro settings. Src kinase inhibition may be candidate to further research in human RA. 相似文献
306.
[目的] 总结徐光星教授依主次病机从燥热伤肺、气阴不足论治肺癌的经验。[方法] 通过跟诊学习,整理相关医案,查阅历代中医文献及国医大师何任教授辨治肿瘤的相关论述与治疗肺癌验案,从病因病机、辨治思路两方面,分析徐教授依主次病机,从燥热伤肺、气阴不足辨治肺癌的临床经验,并佐以两则医案验证。[结果] 徐教授认为,肺癌的形成是由于正气内虚、邪毒侵袭、燥热伤肺、痰瘀互结所致,提出以燥热伤肺、气阴不足为主次病机治疗肺癌,并传承何任教授从益气养阴治疗中晚期肺癌的基本大法,治疗或以燥热伤肺、气阴不足为主病机,清热润燥、益气养阴为主法;或以燥热伤肺、气阴不足为次病机,化痰散结、活血化瘀、清热解毒为主法,兼以清热润燥、益气养阴。所附医案一辨为肺癌后期,以燥热伤肺、气阴不足为主病机,治拟益气养阴、清热润燥、化痰散结;医案二辨为肺癌中期,以痰热壅肺为主病机,燥热伤肺、气阴不足为次病机,治拟清热化痰、养阴润燥,均药治稳好。[结论] 徐光星教授以燥热伤肺、气阴不足为主次病机论治肺癌,疗效确切,临床实用,值得学习与推广。 相似文献