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381.
S. Tariket C. Sut H. Hamzeh-Cognasse S. Laradi O. Garraud F. Cognasse 《Transfusion Clinique et Biologique》2018,25(3):204-209
Even though used systematically with leukocyte reduction, platelet transfusions still cause adverse reactions in recipients. They include Transfusion-Related Acute Lung Injury (TRALI), respiratory distress that occurs within six hours of the transfusion. The pathophysiology of this transfusion complication brings complex cellular communication into play. The role, particularly inflammatory, played by blood platelets in TRALI pathophysiology has been demonstrated, but is still under debate. Blood platelets play a role in inflammation, particularly via the CD40/CD40L (sCD40L) immunomodulator complex. In this study, we examine in particular the specific involvement of the CD40/CD40L (sCD40L) complex in the inflammatory pathogenesis of TRALI. This molecular complex could be a major target in a TRALI prevention strategy. Improving the conditions in which the platelet concentrates (PC) are prepared and stored would contribute to controlling partly the risks of non-immune TRALI. 相似文献
382.
Nuray Akkaya Nilgün Simsir Atalay Selin Taflan Selcuk Hakan Alkan Necdet Catalbas Füsun Sahin 《International journal of clinical oncology / Japan Society of Clinical Oncology》2013,18(2):285-292
Background
We aimed to determine the frequency of fibromyalgia syndrome (FM) in operated breast cancer patients and to research the relationship between FM and the severity of fatigue and quality of life in these breast cancer patients.Methods
The demographic data of 101 operated breast cancer patients were recorded. The patients who had pain were then classified as having regional pain (RP), widespread pain without FM (WP), and widespread pain with FM (WFM). The FM diagnosis was based on the American College of Rheumatology (ACR) criteria. The severity of fatigue was evaluated with the Brief Fatigue Inventory, the disease impact was evaluated with the Fibromyalgia Impact Questionnaire (FIQ), and the quality of life was evaluated with the European Organization for Research on Treatment of Cancer questionnaire Quality of Life-C30 (EORTC-QoL-C30).Results
There was no pain in 38 (37.6%) patients, whereas there was pain in 63 (62.4%) patients (N = 42, 41.6% had RP, N = 21, 20.8% had WP). Ten (9.9%) of the entire patient cohort were diagnosed as having FM according to the ACR criteria. There were no differences among the 3 groups in respect to demographic characteristics when patients were classified as RP (N = 42), WP (N = 11), and WFM (N = 10) groups. While there were negative correlations between the FIQ and EORTC-QoL-C30-function score (r = ?0.727) and EORTC-QoL-C30-global score (r = ?0.488), there was a positive correlation between the FIQ and EORTC-QoL-C30-symptom score (r = 0.726).Conclusion
We note that the frequency of FM in the operated breast cancer patients in this study was higher than that reported in normal populations in the literature. Also, we found that the presence of FM had negative effects on the quality of life of the breast cancer patients. Accordingly, in the evaluation of widespread pain and complaints of fatigue in long-surviving breast cancer patients, after metastatic disease is excluded, the probability of FM should be kept in mind, so that appropriate treatment can be initiated to improve their functional status and quality of life. 相似文献383.
384.
Kadir T. Ceyhanli DDS PhD Necdet Erdilek DDS PhD İlkan Tatar DDS PhD Bekir Çetintav DDS PhD 《Australian endodontic journal : the journal of the Australian Society of Endodontology Inc》2014,40(1):12-16
The aim of this study was to compare apical centring ability of nickel titanium (NiTi) ProTaper, RaCe and mainly stainless steel Safesider systems using micro‐computed tomography. Thirty freshly extracted mandibular molars with two separate mesial canals and separate foramina were used for the study. Mesial roots were embedded in acrylic resin and instrumented with the ProTaper, RaCe or Safesider systems. Root canal transportation and centring ability of the instruments were evaluated using superimposed micro‐computed tomography images of the apical 4 mm of the roots taken at 1 mm intervals. One‐way analysis of variance and post hoc Tukey's tests were performed to compare apical transportations. Significant differences were observed between groups at the apical 1, 2 and 3 mm levels (P < 0.05). The reciprocating Safesider system transported root canals significantly more than the other two NiTi systems in the apical 1 mm level (P = 0.001) and more than RaCe system in the apical 2 mm level (P = 0.003). The ProTaper instruments caused more apical root canal transportation than did RaCe instruments at apical 3 mm (P = 0.045). NiTi instrumentation systems showed better centring ability than the mainly stainless steel Safesider system because of the flexible structure of the NiTi alloy. 相似文献
385.
Sevket Arslan Necdet Poyraz Ramazan Ucar Mihrican Yesildag Ahmet Yesildag Ahmet Zafer Caliskaner 《Journal of clinical immunology》2016,36(1):66-72
Purpose
In some primary immunodeficiency (PID) patients, especially in the subgroup with common variable immunodeficiency (CVID), radiosensitivity is a concern and avoidance of repeated radiation exposure has been recommended. To investigate the use of lung Magnetic resonance imaging (MRI) instead of Computed Tomography (CT) for the diagnosis and follow-up of various lesions in the lung parenchyma and airways, especially in PID patients in whom x-ray exposure should be limited.Methods
The study enrolled 23 patients with PID who underwent thorax CT within the last 3 months and/or who will undergo initial radiological assessment. Lung MRI was performed in all patients to compare the pulmonary findings with CT images.Results
MRI performance was weaker at detecting bronchiectasis extension, and a low concordance was found between MRI and CT in the assessment of the number of bronchial generations. CT better identified peripheral airway abnormalities, while CT and MRI gave similar results for detecting the presence and extension of consolidation, bullae, mucus plugging, bronchial wall thickening, bronchiectasis severity and nodules.Conclusions
Despite the low spatial resolution, higher cost, and low availability, we suggest MRI as a possible radiation-free alternative to CT in selected patients with PID.386.
Cagatay Guven Alp Ozgun Borcek Berker Cemil Gokhan Kurt Zuhal Yildirim Nese Lortlar Ucankus Nedret Kilic Necdet Ceviker 《Journal of clinical neuroscience》2010,17(12):1563-1567
Reactive oxygen species (ROS) have been implicated in the pathogenesis of spinal cord injury after both ischemia–reperfusion (I/R) and trauma. This experimental study was designed to investigate the potential effects of infliximab, an anti-tumor necrosis factor-α agent, on I/R injury of the rabbit spinal cord. Eighteen New Zealand white rabbits were divided into three groups, each consisting of six rabbits: sham (no I/R), I/R, and infliximab (I/R + infliximab). Spinal cord ischemia was induced by applying an infrarenal aortic cross clamp for 30 minutes. At 48 hours after ischemia, animals were functionally evaluated using the Tarlov score. Changes in the spinal cord were observed by measuring tissue levels of malondialdehyde (MDA), glutathione (GSH), advanced oxidation protein products (AOPP), and superoxide dismutase (SOD) and by evaluating hematoxylin–eosin-stained sections. At 48 hours after ischemia, the Tarlov scores in the infliximab group were higher than those of the I/R group, MDA and AOPP levels in the I/R group were significantly higher than those in the sham and infliximab groups (p < 0.05), and SOD levels in the infliximab group were significantly higher than those in the I/R and sham groups (p < 0.05). The sham group had higher GSH levels than the infliximab group; however, the difference was not statistically significant (p > 0.05). Histological examination revealed that the infliximab group had significantly less vascular proliferation, edema, and neuron loss than the I/R group. These results indicate that infliximab may protect the spinal cord against injury in a rabbit I/R model. 相似文献
387.
388.
Mahir Ozmen Baris Zulfikaroglu Necdet Ozalp Munevver Moran Perihan Soydinc Ipek Ziraman 《American journal of surgery》2010,199(6):741-745
Background
Both totally extraperitoneal (TEP) and open preperitoneal (Stoppa) procedures involve the placement of prosthetic material preperitoneally. Because the prosthetic material overlies the femoral artery and vein, the aim of this study was to assess its effect on the velocities and diameters of the artery and vein using color Doppler ultrasonography in both approaches.Methods
Sixty-four patients with bilateral groin hernias were prospectively randomized to undergo either TEP (n = 32) or Stoppa (n = 32) repair. All patients underwent color Doppler ultrasound 6 months after the procedures, and the median follow-up period was 18 months.Results
Neither mean diameter nor mean flow velocity was changed by the insertion of the mesh preperitoneally. The only change was observed in peak systolic femoral arterial blood velocity, which was significantly decreased in the Stoppa group. Also, no patient in this study developed clinically significant deep venous thrombosis during 6 months of follow-up.Conclusions
The insertion of a prosthetic mesh during TEP and Stoppa procedures does not influence the mean peak flow velocities and cross-sectional areas of the vessels in the inguinal region and can be used safely for open and laparoscopic preperitoneal approaches. 相似文献389.
390.