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81.
Rahim Amini Narges Nosrati Razieh Yazdanparast Mahsa Molaei 《Liver international》2009,29(8):1216-1221
Background: In this study, we tried to evaluate whether the ethyl acetate (EtOAc) extract of Teucrium polium, with a high antioxidant activity, is able to prevent the incidence of nonalcoholic steatohepatitis. Methods: Nonalcoholic steatohepatitis was induced in male N‐Mary rats using a methionine/choline‐deficient (MCD) diet. Rats were given normal diet (A), normal diet+EtOAc extract (B), MCD diet (C) and MCD diet+EtOAc (D). Results: The MCD diet led to grade 1 liver steatosis, inflammation and ballooning degeneration. In group D, these factors abated to grade 0 in 80% of the rats. In groups receiving the EtOAc extract, lipoprotein profiles had significantly improved relative to those not receiving the extract. Also, a dramatic reduction was observed in the sera alkaline phosphatase, aspartate aminotransferase and alanine aminoteransferase activities. The activities of the liver superoxide dismutase, glutathione peroxidase and glutathione reductase enzymes were also enhanced. Conclusion: The EtOAc extract could reverse the adverse effects of the MCD diet. 相似文献
82.
Abdolvahab Moradi Shahryar Semnani Gholamreza Roshandel Narges Mirbehbehani Abbasali Keshtkar Mohsen Aarabi Abbas Moghaddami Fatemeh Cheraghali 《Iranian journal of pediatrics.》2010,20(3):335-342
Objective
This paper presents the incidence rates of childhood cancers using the data obtained from Golestan population based cancer registry (GPCR) between 2004 and 2006.Methods
GPCR registers only primary cancers based on standard protocols of the international association of cancer registries (IACR). We collect data on newly diagnosed (incident) cancer cases from all public and private diagnostic and therapeutic centers of the whole province. CanReg-4 software was used for data entry and analysis.Findings
Totally 5076 cancer cases (all ages) were diagnosed in GPCR between 2004 and 2006. Of these, 139 (2.74 %) were children (aged 0–14 years) with mean (±SD) age of 8.06 (±4.48) years. The age standardized incidence rates for childhood cancer were 119.8 and 78.3 per 1000000 person-years in male and female children, respectively. Leukemia was the most common childhood cancer in Golestan province of Iran. Lymphomas and central nervous system tumors were the second and third ones, respectively.Conclusion
The incidence rates of childhood cancers were relatively high in Golestan province of Iran. So, controlling of childhood cancers should be mentioned as an important issue in health policy making in this area. 相似文献83.
84.
Khanjani N English DR Sim MR 《Archives of environmental contamination and toxicology》2006,50(3):452-461
A number of studies have suggested that environmental contamination with organochlorine pesticides may be related to risk
of breast cancer. To investigate this association in a rural part of Australia, organochlorine contamination data from a breast
milk organochlorine study conducted in the state of Victoria in 1993 were used. The state was divided into 11 statistical
divisions. Standardized incidence ratios (SIRs) for the 11 regions were calculated using breast cancer incidence data from
1983 to 2002. During that time, 47,250 breast cancer cases occurred in Victoria, which had an average population of 2,147,409
women. The Ovens-Murray region, which was the region most contaminated with organochlorine pesticides, showed an elevated
SIR of 1.10 (95%CI, 1.03–1.17), although two other regions with lower organochlorine contamination levels also had elevated
SIRs. The rural part of the Ovens-Murray region, where the main pesticide use occurred, had the highest SIR, 1.15 (95%CI,
1.07–1.23). We did not find any significant correlation between organochlorine contamination and the age-standardized rate
of breast cancer across all regions. But a positive dose-response relationship using an adjusted negative binomial model was
detected for heptachlor epoxide. Our study may provide limited support for the role of environmental contamination with organochlorine
pesticides in the development of breast cancer. 相似文献
85.
Development of a multiplex nested consensus PCR for detection and identification of major human herpesviruses in CNS infections. 总被引:2,自引:0,他引:2
Narges Kharazani Tafreshi Majid Sadeghizadeh Samad Amini-Bavil-Olyaee Ali Mohammad Ahadi Issa Jahanzad Mohammad Hassan Roostaee 《Journal of clinical virology》2005,32(4):318-324
BACKGROUND: Rapid, sensitive and economical detection and identification of human herpesviruses as causative agents of central nervous system (CNS) infections are of clinical importance. The traditional methods for the detection of herpesviruses in CNS infections all suffer from limitations. PCR has a potential to overcome each of them. OBJECTIVES: The aims of this study were reducing the number of primers in multiplex PCR and increasing the sensitivity of the assay by nested PCR. STUDY DESIGN: A multiplex nested consensus PCR (MNC-PCR) was developed for the simultaneous detection of major human herpesviruses. A pair of conserved primers was designed for detection of HSV-1, HSV-2, CMV and EBV and another pair of conserved primers for nested PCR. For VZV, a different pair of primers was designed and another pair of primers for nested PCR. A reduction in the number of designed primer pairs (from five pairs to two in both stages of PCR) is an advantage in this assay. One hundred forty-seven cerebral spinal fluid (CSF) samples from patients that showed clinical manifestation of CNS infections were tested. Results of MNC-PCR in CSF samples were compared with those of single PCR assay for each individual DNA virus. Sensitivity of the assay was determined with a plasmid containing VZV DNA binding protein gene and another plasmid for HSV-1 DNA polymerase gene. False negative results (due to the presence of inhibitor of DNA amplification in CSF samples) were avoided by the inclusion of beta2-microglobulin primers in the MNC-PCR assay as an internal control. RESULTS: Positive results were obtained in 20 CSF samples (8 HSV-1, 2 HSV-2, 4 CMV, 3 VZV, 3 HSV-1/CMV, CMV/VZV and HSV-1/EBV coinfections). The comparison between single PCR and MNC-PCR showed a marked increase in sensitivity of MNC-PCR test, since six negative samples in single PCR proved positive in MNC-PCR (P<0.005). Sensitivity was determined 1-5 plasmid copies for VZV and 50-100 plasmid copies for HSV-1. CONCLUSIONS: The MNC-PCR assay presented in this study can provide a rapid, sensitive and economical method for detection of viral infections and is applicable to small volumes of CSF samples. 相似文献
86.
The Groucho/Tle family of corepressor proteins is known to regulate multiple developmental pathways. Applying the dominant-negative effect of the short member Aes, we demonstrate here a critical role of this gene family also for ear development. Misexpression of Aes in medaka embryos resulted in reduced size or loss of otic vesicles, whereas overexpression of the full-length Groucho protein Tle4 gave the opposite phenotype. These results are in close agreement with phenotypes observed for eye formation, suggesting a similar role for Groucho/Tle proteins in the developmental pathways of both sensory organs. Furthermore, by using the heat-inducible HSE promoter, we observed reversible branching of the embryonic axis upon Aes misexpression, indicating a transient duplication of the organizer. Groucho proteins, therefore, are critical for organizer maintenance. 相似文献
87.
Characteristic features of cutaneous melanoma in a dermatology referral centre in Tehran,Iran
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88.
89.
Bidkhori Hamid Reza Hedayati-Moghaddam Mohammad Reza Mosavat Arman Valizadeh Narges Tadayon Mohsen Ahmadi Ghezeldasht Sanaz Rafatpanah Houshang Rezaee Seyed Abdolrahim 《Journal of neurovirology》2020,26(3):338-346
Journal of NeuroVirology - Interleukin (IL)-12, IL-18, and interferon gamma (IFN-γ) can induce Th1-inflammatory responses in favor of HTLV-1-associated myelopathy/tropical spastic paraparesis... 相似文献
90.
Narges Pourmorteza Maasoumeh Jafarpour Fahimeh Feizpour Abdolreza Rezaeifard 《RSC advances》2022,12(8):4931
In this work, the photocatalytic efficiency of Cu(ii)–vitamin C complex immobilized on titanium dioxide nanoparticles was exploited in the photo-assisted homocoupling reaction of aryl boronic acids under heterogeneous conditions. The homocoupling reaction affords the corresponding symmetrical biaryls in 50–97% yields at ambient temperature in the air under visible light irradiation without any need for any additive such as base or oxidant. This method tolerates various substituents on the aryl boronic acids such as halogen, carbonyl, and a nitro group. The light-dependent photocatalytic performance of the title catalyst evaluated by action spectra revealed a maximum apparent quantum efficiency (AQYs) at 410 nm demonstrating the visible-light-driven photocatalytic reaction. The as-prepared nano biophotocatalyst proved to be reusable at least six times without losing its activity. Thus this work exhibits a favorable method from the environmental and economic point of view which enables the industrially important reactions such as coupling reactions, to be carried out efficiently under photocatalytic and practically attainable conditions.TiO2–ascorbic acid (AA)–Cu(ii), nanohybrid is active in the selective aerobic oxidative homocoupling of aryl boronic acids under heterogeneous conditions in air and visible light conditions. 相似文献