全文获取类型
收费全文 | 4782篇 |
免费 | 224篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 46篇 |
妇产科学 | 82篇 |
基础医学 | 732篇 |
口腔科学 | 144篇 |
临床医学 | 310篇 |
内科学 | 1361篇 |
皮肤病学 | 74篇 |
神经病学 | 375篇 |
特种医学 | 114篇 |
外科学 | 817篇 |
综合类 | 16篇 |
一般理论 | 1篇 |
预防医学 | 168篇 |
眼科学 | 39篇 |
药学 | 358篇 |
中国医学 | 8篇 |
肿瘤学 | 364篇 |
出版年
2022年 | 46篇 |
2021年 | 84篇 |
2020年 | 49篇 |
2019年 | 59篇 |
2018年 | 91篇 |
2017年 | 73篇 |
2016年 | 69篇 |
2015年 | 82篇 |
2014年 | 91篇 |
2013年 | 112篇 |
2012年 | 159篇 |
2011年 | 219篇 |
2010年 | 113篇 |
2009年 | 110篇 |
2008年 | 189篇 |
2007年 | 188篇 |
2006年 | 240篇 |
2005年 | 191篇 |
2004年 | 207篇 |
2003年 | 169篇 |
2002年 | 200篇 |
2001年 | 181篇 |
2000年 | 171篇 |
1999年 | 168篇 |
1998年 | 52篇 |
1997年 | 40篇 |
1996年 | 47篇 |
1995年 | 45篇 |
1994年 | 28篇 |
1993年 | 27篇 |
1992年 | 148篇 |
1991年 | 132篇 |
1990年 | 116篇 |
1989年 | 127篇 |
1988年 | 105篇 |
1987年 | 94篇 |
1986年 | 96篇 |
1985年 | 90篇 |
1984年 | 60篇 |
1983年 | 57篇 |
1982年 | 27篇 |
1979年 | 69篇 |
1978年 | 32篇 |
1977年 | 33篇 |
1976年 | 26篇 |
1975年 | 28篇 |
1973年 | 26篇 |
1972年 | 25篇 |
1970年 | 29篇 |
1968年 | 26篇 |
排序方式: 共有5028条查询结果,搜索用时 15 毫秒
91.
92.
Noboru Hanaoka MD Ryu Ishihara MD Yoji Takeuchi MD Motoyuki Suzuki MD Hirokazu Uemura MD Takashi Fujii MD Kunitoshi Yoshino MD Noriya Uedo MD Koji Higashino MD Takashi Ohta MD Hiromitsu Kanzaki MD Masao Hanafusa MD Kengo Nagai MD Fumi Matsui MD Hiroyasu Iishi MD Masaharu Tatsuta MD Yasuhiko Tomita MD 《Head & neck》2013,35(9):1248-1254
93.
94.
95.
Hisashi Ishihara Mitsuhiro Okano Pengfei Zhao Yukihide Maeda Kazunori Nishizaki 《Acta oto-laryngologica》2016,136(10):1011-1016
Conclusion: Significant expression of macrophage migration inhibitory factor and its receptor (CD74) was observed in both the middle ear and inner ear in experimental otitis media in mice. Modulation of macrophage migration inhibitory factor and its signaling pathway might be useful in the management of inner ear inflammation due to otitis media.Objectives: Inner ear dysfunction secondary to otitis media has been reported. However, the specific mechanisms involved are not clearly understood. The aim of this study is to investigate the expression of macrophage migration inhibitory factor and CD74 in the middle ear and inner ear in lipopolysaccharide-induced otitis media.Method: BALB/c mice received a transtympanic injection of either lipopolysaccharide or phosphate-buffered saline (PBS). The mice were sacrificed 24?h after injection, and temporal bones were processed for polymerase chain reaction (PCR) analysis, histologic examination, and immunohistochemistry.Results: PCR examination revealed that the lipopolysaccharide-injected mice showed a significant up-regulation of macrophage migration inhibitory factor in both the middle ear and inner ear as compared with the PBS-injected control mice. The immunohistochemical study showed positive reactions for macrophage migration inhibitory factor and CD74 in infiltrating inflammatory cells, middle ear mucosa, and inner ear in the lipopolysaccharide-injected mice. 相似文献
96.
Junko?KishikawaEmail author Shinsuke?Kazama Koji?Oba Kiyoshi?Hasegawa Hiroyuki?Anzai Yuzo?Harada Hiroyuki?Abe Keisuke?Matsusaka Kumiko?Hongo Masaru?Oba Koji?Yasuda Kensuke?Otani Takeshi?Nishikawa Toshiaki?Tanaka Junichiro?Tanaka Tomomichi?Kiyomatsu Keisuke?Hata Kazushige?Kawai Hiroaki?Nozawa Hironori?Yamaguchi Soichiro?Ishihara Eiji?Sunami Tetsuo?Ushiku Joji?Kitayama Masashi?Fukayama Norihiro?Kokudo Toshiaki?Watanabe 《Annals of surgical oncology》2016,23(6):1916-1923
Background
CD133 is a transmembrane protein that is proposed to be a stem cell marker of colorectal cancer (CRC); however, the correlation between CD133 expression and survival of CRC patients with liver metastasis has not been fully examined.Methods
CD133 expression was evaluated immunohistochemically, both in primary tumors and synchronous liver metastases of 88 consecutive CRC patients, as well as recurrent lesions in the remnant liver of 27 of these 88 patients. The relationship between CD133 expression and clinicopathological characteristics, recurrence-free survival, and overall survival (OS) was analyzed.Results
CD133 expression in liver metastases (mCD133) was detected in 50 of 88 patients (56.8 %), and had significant correlation with CD133 expression in primary lesions (pCD133) (p < 0.001). CD133 expression in liver recurrent lesions (recCD133) also had a significant correlation with mCD133 (p < 0.001). mCD133+ patients had significantly longer disease-free survival (p = 0.043) and OS (p = 0.014) than mCD133? patients. In addition, mCD133+ patients had a significantly lower rate of extrahepatic recurrence (p < 0.001).Conclusions
Patients without CD133 expression in liver metastasis had significantly shorter survival, perhaps because mCD133? patients had a significantly higher rate of extrahepatic recurrence.97.
Glycaemic control is a predictor of infection‐related hospitalization on haemodialysis patients: Miyazaki Dialysis Cohort study (MID study) 下载免费PDF全文
98.
99.
100.
Tsuyoshi Ozawa MD Shinsuke Kazama MD PhD Takashi Akiyoshi MD PhD Koji Murono MD Satomi Yoneyama MD PhD Toshiaki Tanaka MD PhD Junichiro Tanaka MD PhD Tomomichi Kiyomatsu MD PhD Kazushige Kawai MD PhD Hiroaki Nozawa MD PhD Takamitsu Kanazawa MD PhD Hironori Yamaguchi MD PhD Soichiro Ishihara MD PhD Eiji Sunami MD PhD Joji Kitayama MD PhD Teppei Morikawa MD PhD Masashi Fukayama MD PhD Toshiaki Watanabe MD PhD 《Annals of surgical oncology》2014,21(8):2650-2658