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41.
A nurse practitioner (NP) program to improve postpartum appointment keeping in an outpatient family planning clinic is described and evaluated. The subjects (N = 59) were non-high-risk obstetric patients prescheduled to be seen at 6 weeks postpartum by the NP. Two groups were identified by convenience sampling: Group A (n = 25), the nonintervention group, and Group B (n = 34), the intervention group. Two types of intervention were used: a postpartum telephone call after discharge (n = 11), or a predischarge postpartum visit (n = 23). Results suggest that those in the intervention group were more likely to keep their appointments (p less than .02); only the postpartum visit increased the probability of appointment keeping (p less than .05). 相似文献
42.
Robertson NP; Shaunak S; Compston DA 《QJM : monthly journal of the Association of Physicians》1998,91(4):309-313
We retrospectively analysed patients seen in a rapid referral clinic to
identify those with abnormalities genuinely requiring urgent assessment,
and to evaluate the impact of the clinic on routine services. After
advertising the availability of the service, 25% of telephone referrals
from primary-care physicians led to identification of patients considered
suitable for urgent evaluation. We assessed 350 patients over an 18-month
period. After neurological review, relevant abnormalities were identified
in 73%, and 33% were considered to have warranted urgent assessment. In
addition, 74% required radiological evaluation and 14% had a
neurophysiological procedure; 19.4% were admitted on the same day, 13%
underwent CSF analysis and 34% required some form of therapeutic
intervention. In retrospect, patients with a clinical history of > 11
days rarely warranted urgent referral. Visual failure and diplopia provided
the highest correlation with patients deemed to require urgent assessment,
and syncope and headache the lowest. Despite the number of patients
reviewed, no effect was demonstrated on waiting times for standard
out-patient review.
相似文献
43.
Single arm phase II study of oral vitamin B12 for the treatment of musculoskeletal symptoms associated with aromatase inhibitors in women with early stage breast cancer 下载免费PDF全文
Aleli Campbell MS Rosalinda Heydarian NP Cecilia Ochoa MPH Alok Kumar Dwivedi PhD Zeina A. Nahleh MD 《The breast journal》2018,24(3):260-268
Breast cancer patients receiving endocrine therapy with aromatase Inhibitors (AIs) often experience musculoskeletal and joint‐related side effects. The purpose of this study was to evaluate the effect of Vitamin B12 supplements on musculoskeletal symptoms such as pain and arthralgias induced by AIs and to correlate response with serum and inflammatory biomarkers. Upon receiving approval by the Institutional Review Board (IRB), the majority of the patients consented into the study were treated at the Texas Tech Breast Care Center. Included were patients who had a diagnosis of invasive breast cancer (Stages I‐III), and were experiencing significant musculoskeletal symptoms associated to AIs. Only patients with an average pain score ≥ 4, as assessed by the Brief Pain Inventory‐Short Form (BPI‐SF) questionnaire, were included in the study. Participants received 2500 mcg of sublingual vitamin B12 daily for 90 days. Assessments at baseline and at 3 months included: BPI‐SF pain scores, the impact on quality of life determined by Functional Assessment of Cancer Therapy–Endocrine Symptoms (FACT‐ES), and correlative serum markers relative to baseline (a pre‐post study). A total of forty‐one patients were enrolled. Average pain scores were improved by 34% (P < .0001) at 3 months compared to baseline. In addition, a 23% improvement in worst pain was noted (P = .0003). Analysis of the results for the FACT‐ES scoring showed improvement on all scales. No significant adverse events were observed. Decrease in pain score was correlated with increased serum B12 levels. This study suggests that Vitamin B12 reduces pain and improves quality of life for patients taking AIs who experienced AI‐related musculoskeletal symptoms. If confirmed in large randomized prospective trials, Vitamin B12 would be a safe and cost‐effective option for the treatment of AI‐related musculoskeletal symptoms. 相似文献
44.
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46.
Chalmers RM; Howard RS; Wiles CM; Hirsch NP; Miller DH; Williams A; Spencer GT 《QJM : monthly journal of the Association of Physicians》1996,89(6):469-476
Twenty-nine patients with a neuronopathic or neuropathic disorder were
referred for assessment of respiratory insufficiency between 1978 and 1994.
Diagnoses included spinal muscular atrophy (6), chronic idiopathic
demyelinating neuropathy (4), Vialetto-van Laere syndrome (3), hereditary
motor and sensory neuropathy (3) and a miscellaneous group (5). We also
describe seven patients with Guillain-Barre syndrome (GBS) who required
long-term ventilatory support for over 6 months to 7 years after the
initial illness. Respiratory insufficiency occurred as a consequence of
respiratory muscle weakness, impaired bulbar function and restrictive lung
defects. In some groups presentation was with progressive nocturnal
hypoventilation culminating in acute respiratory failure. Five patients
with GBS or chronic idiopathic demyelinating neuropathy were weaned from
ventilatory support up to 18 months after the initial illness. The
remaining 24 patients required continuous or nocturnal ventilatory support
using intermittent positive-pressure ventilation (13), negative pressure
ventilation (4), nasal-mask-delivered intermittent positive-pressure
ventilation (4), nasal-mask-delivered continuous positive-pressure
ventilation (3), mouthpiece-assisted ventilation by day (2) and rocking bed
(1). None have been weaned from support after a period of ventilation
ranging from one month to 10 years. Eight patients have subsequently died.
相似文献
47.
Alyssa Izquierdo BS Franziska Plessow PhD Kendra R. Becker PhD Christopher J. Mancuso BS Meghan Slattery NP Helen B. Murray BA Andrea S. Hartmann PhD Madhusmita Misra MD MPH Elizabeth A. Lawson MD Kamryn T. Eddy PhD Jennifer J. Thomas PhD 《The International journal of eating disorders》2019,52(4):419-427
48.
Elissa M. Ozanne PhD rea Loberg Sherwood Hughes Christine Lawrence Brian Drohan MS Alan Semine MD Michael Jellinek MD Claire Cronin MD Frederick Milham MD MBA Dana Dowd RN NP Caroline Block MD Deborah Lockhart John Sharko MS Georges Grinstein PhD Kevin S. Hughes MD 《The breast journal》2009,15(2):155-162
Abstract: Despite advances in identifying genetic markers of high risk patients and the availability of genetic testing, it remains challenging to efficiently identify women who are at hereditary risk and to manage their care appropriately. HughesRiskApps, an open-source family history collection, risk assessment, and Clinical Decision Support (CDS) software package, was developed to address the shortcomings in our ability to identify and treat the high risk population. This system is designed for use in primary care clinics, breast centers, and cancer risk clinics to collect family history and risk information and provide the necessary CDS to increase quality of care and efficiency. This paper reports on the first implementation of HughesRiskApps in the community hospital setting. HughesRiskApps was implemented at the Newton-Wellesley Hospital. Between April 1, 2007 and March 31, 2008, 32,966 analyses were performed on 25,763 individuals. Within this population, 915 (3.6%) individuals were found to be eligible for risk assessment and possible genetic testing based on the 10% risk of mutation threshold. During the first year of implementation, physicians and patients have fully accepted the system, and 3.6% of patients assessed have been referred to risk assessment and consideration of genetic testing. These early results indicate that the number of patients identified for risk assessment has increased dramatically and that the care of these patients is more efficient and likely more effective. 相似文献
49.
Rai NP 《中国医药工业杂志》2009,40(4)
醇或酚与2当量叔丁基溴在0.1当量碳酸铅催化下,35~45℃搅拌1~2.25h,得相应的叔丁基醚,14例收率75%~96%。 相似文献
50.
JK Gass SK Chan E Rytina DC Greenberg NP Burrows 《Journal of the European Academy of Dermatology and Venereology》2010,24(5):601-603
Background Merkel cell carcinoma (MCC) is a rare malignant cutaneous tumour, the incidence of which is increasing. Second malignancies have been reported to occur with high incidence in these patients. Objectives We report the rate and nature of multiple malignancies in patients with MCC treated over a 10 year period in Addenbrooke’s Hospital in Cambridge, United Kingdom, as well as the temporal relationship of these additional malignancies to the diagnosis of MCC. Results The 27 patients had an approximately equal sex incidence with a median age at diagnosis of 79 years. Seventy percent (n=19) of patients had a second primary malignant tumour; and 7 of these patients had two or more tumours in addition to the MCC. Eighteen patients had additional cutaneous malignancies: melanoma, squamous cell carcinoma and basal cell carcinoma, and 8 patients presented non‐cutaneous malignancy including colorectal, haematological and breast tumours. Of the 28 additional tumours in our patients, half were diagnosed prior to presentation of MCC, 32% within 6 months of diagnosis, and 18% between 6 months and 3 years after diagnosis. Possible reasons for the high rate of additional tumours in this population are discussed. Conclusions Our figures reflect a higher incidence of multiple malignancies in those with Merkel cell tumour than has previously been reported. This has important implications for the care and surveillance of these patients. 相似文献