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排序方式: 共有121条查询结果,搜索用时 31 毫秒
101.
Erick de la Cruz Hernández Alejandro Mohar Betancourt Marcela Lizano Soberón 《Clinical & translational oncology》2004,6(5):263-271
Resumen La infección del virus del papiloma humano (VPH) es el principal factor de riesgo para el desarrollo del cáncer cervicouterino.
El ciclo de vida del VPH está ligado al proceso de diferenciación epitelial. Cuando estos virus infectan las células basales
se mantienen como elementos autorreplicativos con bajos niveles de expresión génica. A medida que los estratos celulares se
van differenciando, los niveles de replicación del genoma vírico aumentan y se sintelizan las proteínas víricas tardías, con
lo que se inicia la formación de partículas infecciosas. Aun cuando las proteínas E1 y E2 son los elementos principales en
la replicación, otras proteínas víricas también contribuyen promoviendo o replrimiendo la transcripción de ciertos genes víricos.
Sin embargo, no está claro cómo es que estos factores de replicación son regulados durante el ciclo de vida del VPH. Por lo
tanto, resulta importante entender estos mecanismos de regulación, además de las interacciones de las proteínas víricas con
múltiples dianas celulares, que promueven la transformación celular.
相似文献
102.
Prognostic factors on 45 cases of phyllodes tumors 总被引:3,自引:0,他引:3
Meneses A Mohar A de la Garza-Salazar J Ramírez-Ugalde T 《Journal of experimental & clinical cancer research : CR》2000,19(1):69-73
The authors, in order to obtain a diagnostic index for phyllodes tumors and identified histological parameters that will predict the clinical course of this neoplasm, developed a histological degree of aggressiveness based on specific histological parameters, including: stromal:gland ratio, tumor margins, mitotic index and degree of stromal pleomorphism. Three categories were established: benign, intermediate and malignant. The probability of recurrence was estimated by the relative risk and by a multivariate Cox analysis. A strong and significant association was observed between this histological index and recurrence. The relative risk was 6.0 for intermediate lesions and 11.4 for malignant lesions when compared with the benign category. The microscopic examination of all axillary lymph nodes was negative for metastatic disease. In the multivariate analysis, the stroma:gland ratio was the strongest predictor for recurrence. These results indicate that by assigning a numerical value to certain histopathologic variables a better correlation with the clinical outcome of the patient can be obtained. 相似文献
103.
Epidemiology of cervical cancer 总被引:4,自引:0,他引:4
In 1985, 7.6 million cases of cancer were diagnosed in 24 different regions all over the world (1). Globally, cervical cancer is the fifth most frequent malignancy and second among women, with an annual estimate of 471,000 new cases and 213,000 deaths. The age-adjusted incidence rates for developed countries are 7.6 to 11.8 per 105 and for developing countries, 17.6 to 46.8 per 105 (1,2). This variation in the incidence of cervical cancer is also present within countries, where rural and poor areas have the highest rates. 相似文献
104.
N Mohar 《Acta dermato-venereologica》1980,60(6):509-513
A family genealogy, comprising four cases of familial multiple lipomatosis, making their appearance one after the other in three generations is reported. Two cases with impressive clinical features are presented in detail. This report contributes to the opinion that the disease is transmitted by the autosomal dominant route of inheritance. 相似文献
105.
Frank C Hampel Paul H Ratner Niran J Amar Julius H van Bavel Dale Mohar Carol J Fairchild G Michael Wall Michael J Brubaker Margaret Drake Krista M Crenshaw 《Allergy and asthma proceedings》2006,27(3):202-207
Seasonal allergic rhinitis (SAR) exerts a significant adverse impact on health-related quality of life (QoL) and productivity of those who suffer from it. Unfortunately, some therapies for SAR also have a negative impact. Therefore, it is important to scrutinize the influence of new SAR therapies on patients' QoL and ability to function. The purpose of this study was to evaluate the effect of a new nasal antihistamine, olopatadine, on QoL in SAR patients. In a multicenter, randomized, double-blind SAR study comparing olopatadine 0.6 and 0.4% to placebo nasal spray, patients completed the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) at baseline and after 2 weeks of treatment. The RQLQ is a validated questionnaire that addresses overall QoL and 7 domains of impairment associated with rhinoconjunctivitis (activities, sleep, non--nose/eye allergy symptoms, practical problems, nasal symptoms, eye symptoms, and emotional impairment). The overall RQLQ mean changes from baseline with olopatadine 0.6% (-1.1 +/- 1.4) and 0.4% (-1.1 +/- 1.3) nasal sprays were superior (p < 0.05) to placebo (-0.8 +/- 1.2). Olopatadine spray 0.6% was superior to placebo in six of the seven RQLQ domains and olopatadine 0.4% was superior to placebo in five RQLQ domains (p < 0.05). The correlation between the olopatadine 0.6% mean total symptom scores and mean RQLQ score was r = 0.66 (p < 0.0001), indicating that the enhancement in QoL derived from olopatadine therapy was significantly associated with symptom reduction. Olopatadine nasal spray is an effective antiallergy medication that significantly improves the QoL of patients suffering from SAR. 相似文献
106.
The impact of the use of intraoperative radiotherapy on costs,travel time and distance for women with breast cancer in the Mexico City Metropolitan Area
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Juan Enrique Bargallo‐Rocha MD Enrique Soto‐Perez‐de‐Celis MD Msc Francisco Javier Picó‐Guzmán Carlos Eduardo Quintero‐Rodríguez MD David Almog Gabriel Santiago‐Concha MD Christian Haydee Flores‐Balcazar MD Jaime Corona MD Rafael Vazquez‐Romo MD Cynthia Villarreal‐Garza MD Alejandro Mohar MD PhD 《Journal of surgical oncology》2017,116(6):683-689
107.
M T Salles O Neyra L Taja G Cervantes M Gagnière M Cerrillo A Mohar A Osornio E Reynoso G Gorodezky 《Cancer Genetics and Cytogenetics》1992,59(1):80-83
We report a case of non-Hodgkin's lymphoma in a 16-year-old male, whose peripheral white blood cells have a t(8;13)(q24;q14). There are no previous reports that describe this association. Although the tumor cells were not studied, we discuss the possible link between this finding and the development of the malignant lymphoma. 相似文献
108.
109.
Diagnostic yield of gastric biopsy specimens when screening for preneoplastic lesions 总被引:1,自引:0,他引:1
Guarner J Herrera-Goepfert R Mohar A Smith C Schofield A Halperin D Sanchez L Parsonnet J 《Human pathology》2003,34(1):28-31
The Sydney system recommends sites and numbers of stomach biopsies (mapping) for evaluation of Helicobacter pylori-associated lesions. The diagnostic yield of the recommended mapping technique in populations at high risk for gastric preneoplastic lesions has not been established. We evaluated pathology data from 733 endoscopies performed as part of an intervention study that assessed the effects of H. pylori treatment on preneoplastic conditions. Two pathologists assessed whether the mapping sequence of the 7 biopsy specimens obtained during each endoscopy was correctly followed and graded the specimens using the Sydney classification for gastritis. If the mapping sequence was followed, then we evaluated whether the amount of information obtained from 3 biopsy samples approximated that obtained from 5 and 7 biopsy samples. The mapping sequence was followed in only 239 (33%) endoscopies, indicating that experienced endoscopists can inadvertently misidentify sites in the stomach when obtaining specimens. When data from 7 specimens were used, H. pylori was found in 205 endoscopies, atrophy in 152, metaplasia in 135, and dysplasia in 22. When data from 3 specimens were used, the sensitivity was 99% for presence of H. pylori, 82% for atrophy and metaplasia, and 81% for dysplasia. When data from 5 specimens were used, the sensitivity was 100% for H. pylori, 96% for atrophy, and 95% for metaplasia and dysplasia. Although site-specific biopsy mapping is difficult in practice, the recommendations of the Sydney system as to the location and number of gastric biopsy specimens can adequately identify significant gastric histopathology. 相似文献
110.
Ramírez-Amador V Esquivel-Pedraza L Lozada-Nur F De la Rosa-García E Volkow-Fernández P Súchil-Bernal L Mohar A 《Oral oncology》2002,38(5):460-467
In this double-blind, randomized trial, we compared the clinical efficacy of intralesional vinblastine (VNB) and 3% sodium tetradecyl sulfate (STS) in the treatment of oral Kaposi's sarcoma (OKS). Subjects with OKS were randomly assigned to receive a single intralesional injection of either VNB or STS, at a standard dose (0.2 mg/cm(2)). Differences were evaluated by the Mann-Whitney U and Fisher's exact tests. Sixteen HIV-infected patients were included, eight received VNB and eight received STS; clinical response was evaluated at days 7, 14, and 28 following treatment. Tumor size reduction was 0.68 and 0.61 cm in the VNB and STS groups, respectively (P=0.80). Two VNB patients had complete or partial response whereas four STS subjects had partial responses (P=0.61). Patients in both groups experienced minimal toxicity. We conclude that intralesional vinblastine or STS are adequate for the management of OKS. The benefits of STS are its low cost and ease of use. 相似文献