Rice-based breakfast improves fasting glucose and HOMA-IR in Korean adolescents who skip breakfast,but breakfast skipping increases aromatic amino acids associated with diabetes prediction in Korean adolescents who skip breakfast: a randomized,parallel-group,controlled trial

BACKGROUND/OBJECTIVESAdolescents who skip breakfast have an increased prevalence of chronic diseases. Thus, we aimed to evaluate whether the intake of rice-based breakfast had positive effects on blood glucose indices and to determine the possibility of diabetes prevalence in Korean youths who habitually skip breakfast.SUBJECTS/METHODSIn this randomized parallel-group controlled trial, 81 subjects who were suitable for compliance among 105 middle-and high-school students aged 12-18 years who usually skipped breakfast were included in this study (rice-meal group [RMG], n = 26; wheat-meal group [WMG], n = 29; general-meal group [GMG], n = 26). The RMG and WMG received a rice-based breakfast and a wheat-based breakfast for 12 weeks, respectively. The anthropometric indices, blood glucose indices, and metabolites were measured at baseline and the endpoint, respectively.RESULTSThe mean body weights in the RMG, WMG, and GMG groups at the endpoint were 62.44 kg, 61.80 kg, and 60.28 kg, respectively, and the mean body weights of the WMG and GMG groups at the endpoint were significantly higher than that at baseline (P < 0.05). The levels of fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) values were significantly decreased in the RMG group at the endpoint compared to baseline (P < 0.05, P < 0.05, respectively). The levels of tryptophan and tyrosine in the WMG group at the endpoint were significantly higher than that those at baseline (P < 0.01, P < 0.05, respectively).CONCLUSIONSRice-based breakfast has positive effects on fasting insulin levels and HOMA-IR in Korean adolescents who skip breakfast. Additionally, it was found that a skipping breakfast could increase the prevalence of diabetes in adolescents who skip breakfast. Therefore, in addition to reducing breakfast skipping, it is vital to develop a rice-based menu that fits teenage preferences to prevent chronic diseases such as diabetes.Trial RegistrationClinical Research Information Service Identifier: KCT0004089     

多层螺旋CT评估下眼睑增龄性改变

目的 通过多层螺旋CT评估眼轮匝肌厚度与眼眶脂肪脱垂长度的增龄性改变.方法 将148例接受头部多层螺旋CT患者分为青年组(18～44岁)54例、中年组(45～59岁)30例和老年组(≥60岁)64例,于斜矢状位图像上测量右眼眼轮匝肌厚度、眼眶脂肪脱垂长度,分析年龄、性别、眼轮匝肌厚度与眼眶脂肪脱垂长度的关系.结果 青年...     

卵巢硬化性间质瘤的研究进展

卵巢硬化性间质瘤是一种临床罕见的卵巢良性肿瘤,其发病率低,病因不明确,以年轻女性多见,多为单侧肿块,常因月经不规则出血或体检发现腹部包块而就诊。影像学检查可见“湖岛征”、“快进慢出”和“向心性强化”等改变。病理组织学见单侧类圆形囊实性肿块,“假小叶”为特征性病变。免疫组织化学可见抑制素、波形蛋白和肌动蛋白等阳性表达。确诊主要通过病理组织学诊断,影像学检查具有重要参考价值。术前诊断困难,容易与卵巢纤维瘤、卵泡膜细胞瘤、卵巢库肯勃瘤和颗粒细胞瘤等相混淆。手术治疗为主要治疗手段,多采用患侧肿瘤切除术或附件切除术,术后预后较好,卵巢功能可恢复正常。对于肿瘤细胞出现核分裂象和坏死较多时,需警惕复发风险,建议长期跟踪随访。     

26例活体肾移植供者术后长期安全性观察

目的:评价活体肾移植供肾者术后长期安全性.方法:随访26例活体肾移植供者术后2～8(4.27±2.11)年血肌酐、血压、尿蛋白的变化,并评价供肾对供者心理学的影响.结果:供者术后血肌酐较术前明显升高(P＜0.01),但仍在正常范围内,且一直稳定在一定水平;供者术后血压与术前相比无明显差异;1例供者在术后1个月复查发现微量蛋白尿,经休息后好转,其他供者尿常规检查均为阴性;无1例死亡.1例供者对当初供肾行为表示后悔,觉得供肾对自己带来了一定的心理压力.结论:对于健康供者而言,无偿捐献一侧肾脏是安全可行的,不会给供者带来明显的生命威胁及心理负担,但术前对供者进行安全性评估及术后长期随访是十分必要的.     

Diagnostic significance of long non-coding RNAs expression in tuberculosis patients: A systematic review and meta-analysis

Objectives:It is crucial to identify effective diagnostic biosignatures of tuberculosis (TB) to optimize its treatment. Herein, we conducted a systematic review to elucidate the diagnostic efficacy of long noncoding RNA (lncRNAs) as TB biomarkers.Methods:We searched Medline, Web of Science, Embase, Cochrane Library, CNKI, Wanfang, VIP, and China Biology Medicine disc databases up to February 18, 2020. These studies focusing on lncRNAs as diagnosis markers of TB were collected. STATA 12.0 and Meta-disc1.4 software were used to analyze the data extracted from eligible studies.Results:We included 8 articles with 1058 TB patients, and 1896 healthy controls in our study. The values of pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 0.63, 0.86, 4.48, 0.43, and 10.31, respectively. Additionally, we plotted the summary receiver operating characteristic curve to evaluate the diagnostic accuracy, and the area under the curve was 0.80.Conclusion:The present study is the first meta-analysis to assess the diagnostic accuracy of lncRNAs in TB patients. We found that lncRNAs might constitute potential biomarkers for the diagnosis of TB patients. More population-based high-quality research should be conducted to validate the efficacy lncRNAs in TB patients.     

儿童系统性红斑狼疮患儿甲状腺相关抗体检测的临床意义

目的 探讨儿童系统性红斑狼疮(cSLE)患儿甲状腺相关抗体检测对发现甲状腺损伤及自身免疫性甲状腺炎(AITD)的临床意义。方法 选择2017年1月至2021年8月,在首都儿科研究所附属儿童医院风湿免疫科住院治疗的50例初发cSLE患儿为研究对象,并纳入cSLE组。同时选取在本院体检中心进行体检的50例健康儿童纳入对照组。回顾性分析2组受试儿的一般临床资料和甲状腺相关抗体阳性率,并对cSLE组患儿的临床特征、甲状腺相关抗体阳性率、甲状腺损伤情况、治疗和随访情况进行分析。采用电化学发光法检测促甲状腺素受体抗体(TRAb)、甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)。本研究遵循的程序符合2013年修订的《世界医学协会赫尔辛基宣言》要求,与所有受试儿监护人签署临床研究知情同意书。结果 (1)2组受试儿性别构成比、年龄等一般临床资料比较,差异均无统计学意义(P>0.05)。(2)cSLE组50例患儿中,年龄为4～15岁[(11.0±2.5)岁],均无甲状腺疾病家族史。所有患儿首诊时系统性红斑狼疮(SLE)病情活动评分(SLEDAI-2k)均>5分,仅1例以甲状腺...     

CT及MRI对肝细胞腺瘤病理学特征的显示能力

目的 研究CT及MR对肝细胞腺瘤(Hepatocellular adenoma,HA)病理学特征的显示能力.方法 回顾性分析11例病理确诊的HA(共11个病灶),比较CT及MRI对HA主要组织学特征的显示能力.结果 脂肪变性的病灶8个,MRI判断正确6个,CT3个,有假包膜病灶7例,MRI判断正确6个,CT4个,4个病灶有出血,MRI判断正确3个,CT均未判断有出血;富血供病变9个,MRI和CT均作出准确判断.结论 对于HA脂肪变性、假包膜及出血的显示,MRI优于CT,对于富血供的判断,MRI与CT相同.     

Integrative treatment of herbal medicine with western medicine on coronary artery lesions in children with Kawasaki disease

Background:Kawasaki disease (KD) is a major cause of coronary artery lesions (CALs) in children. Approximately 10% to 20% of children treated with intravenous immunoglobulin are intravenous immunoglobulin-resistant. This study evaluated the efficacy and safety of adding herbal medicine to conventional western medicines versus conventional western medicines alone for CALs in children with KD.Methods:This study searched 9 electronic databases until August 31, 2021. The inclusion criteria were the randomized controlled trials (RCTs) that assessed the CALs in children with KD and compared integrative treatment with conventional western treatments. Two authors searched independently for RCTs, including eligible articles that fulfilled the inclusion criteria, extracted data, and assessed the methodological quality using the Cochrane risk of bias tool. Meta-analysis was conducted using Cochrane Collaboration''s Review Manager 5.4 software. The effect size was presented as the risk ratio (RR), and the fixed-effect models were used to pool the results.Results:The finally selected 12 studies included a total of 1030 KD patients. According to a meta-analysis, the integrative treatment showed better results than the conventional treatment in the CAL prevalence rate (RR = 2.00; 95% confidence interval [CI], 1.49–2.71; P < .00001), CAL recovery rate (RR = 1.27; 95% CI, 1.05–1.54; P = .02), and total effective rate (RR = 1.17; 95% CI, 1.11–1.23; P < .00001). Only 2 studies referred to the safety of the treatment. The asymmetrical funnel plot of the CAL prevalence rate indicated the possibility of potential publication bias.Conclusions:This review found the integrative treatment to be more effective in reducing the CAL prevalence rate and increasing the CAL recovery rate and total effective rate in KD patients than conventional western treatment. However, additional well-designed RCTs will be needed further to compensate restrictions of insufficient trials on safety, methodological quality, and publication bias.     

原发性肠系膜肿瘤的CT诊断

目的:分析原发性肠系膜肿瘤(PMT)的CT表现,探讨CT对其定位及定性诊断的价值.方法:对13例经病理证实原发性肠系膜肿瘤的CT及临床资料进行回顾分析.结果:13例原发性肠系膜肿瘤中4例良性,其余均为恶性;位于小肠系膜10例,结肠系膜3例,肿瘤直径6.4～13.0 cm (平均9.5 cm);纤维瘤2例,平滑肌肉瘤2例,间质瘤4例,淋巴瘤2例,脂肪肉瘤2例,恶性纤维组织细胞瘤1例.结论:PMT CT表现缺乏特异性.CT对体积相对较小的PMT有较高的定位价值,对体积巨大肿瘤定位有一定困难,可较准确判断PMT的良恶性.     

原发性肺癌血中检测sFas的临床价值

目的：探讨sFas在原发性肺癌中的表达及其临床价值。方法：应用ELISA检测40例原发性肺癌标本及30例良性病变中sFas的表达情况。结果：在不同病理类型中sFas表达差异显著（P〈0．05）;在不同TNM分期中：Ⅰ期与Ⅱ期、Ⅰ期与Ⅲ期,sFas表达差异显著（P〈0．05）。在Ⅱ期与Ⅲ期表达差异不显著（P〉0．05）。结论：sFas升高有利于肺癌逃避免疫攻击,有利于其浸润与转移。