全文获取类型
收费全文 | 19998篇 |
免费 | 991篇 |
国内免费 | 99篇 |
专业分类
耳鼻咽喉 | 229篇 |
儿科学 | 460篇 |
妇产科学 | 294篇 |
基础医学 | 2459篇 |
口腔科学 | 580篇 |
临床医学 | 1419篇 |
内科学 | 5470篇 |
皮肤病学 | 408篇 |
神经病学 | 1672篇 |
特种医学 | 365篇 |
外科学 | 3009篇 |
综合类 | 131篇 |
一般理论 | 6篇 |
预防医学 | 1610篇 |
眼科学 | 500篇 |
药学 | 1131篇 |
1篇 | |
中国医学 | 53篇 |
肿瘤学 | 1291篇 |
出版年
2024年 | 14篇 |
2023年 | 149篇 |
2022年 | 389篇 |
2021年 | 728篇 |
2020年 | 340篇 |
2019年 | 628篇 |
2018年 | 748篇 |
2017年 | 425篇 |
2016年 | 456篇 |
2015年 | 565篇 |
2014年 | 732篇 |
2013年 | 958篇 |
2012年 | 1592篇 |
2011年 | 1674篇 |
2010年 | 896篇 |
2009年 | 861篇 |
2008年 | 1353篇 |
2007年 | 1342篇 |
2006年 | 1285篇 |
2005年 | 1216篇 |
2004年 | 1057篇 |
2003年 | 930篇 |
2002年 | 819篇 |
2001年 | 205篇 |
2000年 | 183篇 |
1999年 | 198篇 |
1998年 | 151篇 |
1997年 | 139篇 |
1996年 | 103篇 |
1995年 | 83篇 |
1994年 | 84篇 |
1993年 | 64篇 |
1992年 | 88篇 |
1991年 | 87篇 |
1990年 | 70篇 |
1989年 | 42篇 |
1988年 | 33篇 |
1987年 | 38篇 |
1986年 | 44篇 |
1985年 | 39篇 |
1984年 | 33篇 |
1983年 | 27篇 |
1982年 | 35篇 |
1981年 | 29篇 |
1980年 | 19篇 |
1978年 | 11篇 |
1977年 | 11篇 |
1976年 | 10篇 |
1975年 | 10篇 |
1974年 | 24篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
Marcelo Biscegli Jatene Estela Azeka Edmar Atik Arlindo Riso Carla Tanamati Miguel Barbero Marcial Sergio Almeida de Oliveira 《The Journal of heart and lung transplantation》2005,24(5):638-641
A 28-month-old boy, weighing 11 kg, with severe dilated cardiomyopathy, was transplanted on December 1995. Hypertension and supraventricular tachycardia were detected in the immediate post-operative period, with favorable outcome. After 5 months of clinically asymptomatic follow-up, a dilation in the ascending aorta was observed on routine echocardiogram. Nuclear magnetic resonance imaging (NMRI) confirmed an ascending aortic aneurysm, with a diameter of 38 mm. An operation was performed, a bovine pericardium patch was sutured with reconstruction of the aortic wall, excluding the aneurysm. Good recovery was obtained and the child was discharged on Day 7 postoperatively. A post-operative echocardiogram showed absence of the aortic aneurysm and good surgical results. Another NMRI was done 5 months later, showing an intact ascending aorta. After 64 months, the patients clinical condition was confirmed as normal by echocardiogram. Surgical treatment was successful and the positive results have been maintained. 相似文献
32.
33.
Christophe Doddoli Adrian Aragon Fabrice Barlesi Bruno Chetaille Stéphane Robitail Roger Giudicelli Pierre Fuentes Pascal Thomas 《European journal of cardio-thoracic surgery》2005,27(4):680-685
OBJECTIVE: To assess the therapeutic effect of the extent of lymph node dissection performed in patients with a stage pI non-small-cell lung cancer (NSCLC). METHODS: We analysed data on 465 patients with stage I NSCLC who were treated with surgical resection and some form of lymph node sampling. The median number of lymph node sampled was 10 and the median number of ipsilateral mediastinal lymph node stations sampled was two. We chose to define a procedure that harvested 10 or more lymph nodes and sampled two or more ipsilateral mediastinal stations as a lymphadenectomy, by contrast with sampling when one or both criteria were not satisfied. The effect of the surgical techniques: lymph node sampling (LS; n=207) vs. lymphadenectomy (LA; n=258) on 30-day mortality and overall survival were investigated. RESULTS: A total of 6244 lymph nodes was examined, including 4306 mediastinal lymph nodes. The mean (+/-SD) numbers of removed lymph nodes were 7+/-6.1 per patient following LS vs.18.6+/-9.3 following LA (P=0.001). An average mean of 1+/-0.90 mediastinal lymph node station per patient was sampled following LS vs. 2.7+/-0.8 following LA (P<10(-6)). Overall 30-day mortality rates were 2.4 and 3.1%, respectively. LA was disclosed as a favourable prognosticator at multivariate analysis (Hazard Risk: 1.43; 95% Confidence Interval: 1.00-2.04; P=0.048), together with younger patient age, absence of blood vessels invasion, and smaller tumour size. CONCLUSIONS: Importance of lymph node dissection affects patients outcome, while it does not enhance the operative mortality. A minimum of 10 lymph nodes assessed, and two mediastinal stations sampled are suggested as possible pragmatic markers of the quality of lymphadenectomy. 相似文献
34.
Adaani E Frost Miguel A Qui?ones William A Zoghbi George P Noon 《The Journal of heart and lung transplantation》2005,24(4):501-503
We report the first case in the world literature of a patient with an atrial septal defect, severe pulmonary hypertension, and equalization of pulmonary and systemic pressures, who underwent successful closure of an ASD following prolonged therapy with the intravenous vasodilator epoprostenol. Judicious use of continuous prostacyclin in apparently inoperable patients with congenital heart disease may be associated with significant reversal of pulmonary hypertension, and conversion to an operable state. 相似文献
35.
36.
Transcranial magnetic stimulation over dorsolateral prefrontal cortex in Parkinson's disease. 总被引:4,自引:0,他引:4
OBJECTIVE: Several studies have shown that repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) is effective in the treatment of depression in patients with Parkinson disease (PD). However, since research into the effect of this type of rTMS regime on motor function is limited, we studied the effect of rTMS over the DLPFC on the motor functions in PD patients. METHODS: Thirteen patients were randomly assigned into 2 groups, one receiving real-rTMS (90% of resting motor threshold, 10 Hz, 450 pulses-day for 10 consecutive days) over the DLPFC contralateral to the more affected side, and the other group receiving sham-rTMS. Assessment included a clinical motor evaluation using part III of the Unified Parkinson's Disease Rating Scale (UPDRS), and several motor tasks. The UPDRS was applied before and after 10 days of rTMS. Finger tapping, reach movement, grip movement and gait were measured in each session before and after the rTMS over the 10 day period. RESULTS: Statistical analysis (ANOVA for repeated measures; group *day *side *rTMS) only showed a significant effect for finger tapping, reach movement and gait for the factor day. No significant change was reported for the UPDRS in any group. CONCLUSIONS: Application of rTMS over the DLPFC as a 10 day course had no significant effect on motor functions and clinical motor status, and the improvement in performance of motor tasks can be attributed to the effects of practice. SIGNIFICANCE: rTMS over the DLPFC did not lead to any motor improvement in PD patients. 相似文献
37.
Immunophenotypic, genomic and clinical characteristics of blast crisis of chronic myelogenous leukaemia 总被引:1,自引:0,他引:1
J. M. Hernández R. González-Sarmiento C. Martin M. González I. Sánchez J. Corral A. Orfao M. C. Canizo J. F. san Miguel A. López-borrasca 《British journal of haematology》1991,79(3):408-414
We have studied phenotypic and clinical features in a consecutive series of 45 patients with chronic myelogenous leukaemia (CML) in blast crisis (BC). In addition, in 22 of these patients we have analysed the genotypic characteristics including immunoglobulin, T-cell receptor (TCR) and major breakpoint cluster region (M-bcr) gene organization. The granulomonocytic and megakaryoblastic lineages are the most commonly involved in these BC of CML (33% and 33% of cases, respectively); only 18% of our cases displayed a lymphoid phenotype. Moreover, both morphological and immunophenotypic studies revealed the frequent coexistence of two or three cell populations, especially when the megakaryoblast component is involved. The lymphoid BC displayed the highest incidence of complete remissions although this was not associated with a longer survival. Only minor differences between the different myeloid subgroups were observed. Immunoglobulin heavy chain (IgH) gene rearrangement was found in five of the six lymphoid BC and in one myeloid BC. Only one case showed k light chain gene rearrangement. In all but one myeloid BC the TCR-beta gene was in germline configuration. The TCR-gamma gene was rearranged in all lymphoid and one myeloid BC, while TCR-delta gene rearrangement was detected in 67% and 16% of the lymphoid and myeloid BC, respectively. Most of the lymphoid BC (4/5) had the M-bcr breakpoint in subregion 3, while the myeloid BC had the breakpoint either in subregion 2 or 3. No differences between the different myeloid phenotypic subgroups were observed in relation to breakpoint. 相似文献
38.
39.
The inhibitory action of the major constituent of Sebastiania schottiana (Euphorbiaceae), 2-hydroxy-4,6-dimethoxyacetophenone (xanthoxyline) on contractions induced by agonists and electrical stimulation of smooth and cardiac muscle preparations was analysed. Xanthoxyline (30 to 300 microM) inhibited contractions of the rat uterus, guinea-pig ileum, and urinary bladder induced by several agonists in a non-competitive, non-selective, concentration-related manner, with the IC50's ranging between 47 and 190 microM. Twitches evoked by electrical-stimulation of strips of guinea-pig longitudinal ileum, urinary bladder, dog ureter, and rat left atrium were also inhibited dose-dependently by cumulative additions of xanthoxyline (IC50's between 50 and 480 microM). Xanthoxyline was found to be a potent inhibitor of spontaneous contractions of the circular smooth muscle layer of the dog ureter, yielding an IC50 of 54 microM. Repeated washing of all preparations completely reversed the inhibitory effects of xanthoxyline. Therefore, it appears that xanthoxyline induces a direct and non-selective inhibition of contractions triggered by agonists or electrical stimulation of smooth and cardiac muscle preparations. The elucidation of the mechanism(s) by which xanthoxyline induced muscle relaxation requires further investigations. 相似文献
40.
Miguel J. Farolan M.D. Salve G. Ronan M.D. Lawrence M. Solomon M.D. Deborah S. Loeff M.D. 《Pediatric dermatology》1992,9(3):264-267
A 20-month-old Kuwaiti girl had manifestations of lipoid proteinosis, a rare autosomal recessive disorder seen more commonly in Caucasians. This condition is diagnosed based on clinical, histopathologic, and ultrastructural criteria. Its biochemical and genetic aspects are still poorly understood. 相似文献