全文获取类型
收费全文 | 55660篇 |
免费 | 3683篇 |
国内免费 | 135篇 |
专业分类
耳鼻咽喉 | 419篇 |
儿科学 | 2063篇 |
妇产科学 | 1893篇 |
基础医学 | 6682篇 |
口腔科学 | 736篇 |
临床医学 | 9164篇 |
内科学 | 10200篇 |
皮肤病学 | 840篇 |
神经病学 | 4925篇 |
特种医学 | 1127篇 |
外国民族医学 | 33篇 |
外科学 | 5063篇 |
综合类 | 638篇 |
一般理论 | 79篇 |
预防医学 | 7669篇 |
眼科学 | 822篇 |
药学 | 3200篇 |
1篇 | |
中国医学 | 95篇 |
肿瘤学 | 3829篇 |
出版年
2023年 | 325篇 |
2022年 | 490篇 |
2021年 | 1100篇 |
2020年 | 720篇 |
2019年 | 1169篇 |
2018年 | 1333篇 |
2017年 | 937篇 |
2016年 | 1046篇 |
2015年 | 1160篇 |
2014年 | 1562篇 |
2013年 | 2562篇 |
2012年 | 3715篇 |
2011年 | 3954篇 |
2010年 | 2110篇 |
2009年 | 1960篇 |
2008年 | 3504篇 |
2007年 | 3963篇 |
2006年 | 3852篇 |
2005年 | 3739篇 |
2004年 | 3638篇 |
2003年 | 3447篇 |
2002年 | 3258篇 |
2001年 | 593篇 |
2000年 | 452篇 |
1999年 | 554篇 |
1998年 | 710篇 |
1997年 | 566篇 |
1996年 | 514篇 |
1995年 | 399篇 |
1994年 | 398篇 |
1993年 | 380篇 |
1992年 | 349篇 |
1991年 | 299篇 |
1990年 | 292篇 |
1989年 | 253篇 |
1988年 | 267篇 |
1987年 | 246篇 |
1986年 | 218篇 |
1985年 | 242篇 |
1984年 | 261篇 |
1983年 | 238篇 |
1982年 | 282篇 |
1981年 | 262篇 |
1980年 | 204篇 |
1979年 | 159篇 |
1978年 | 143篇 |
1977年 | 148篇 |
1976年 | 132篇 |
1975年 | 114篇 |
1973年 | 121篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
Christopher L. Knight MD Henry A. Sakowski MD Bruce L. Houghton MD Mary B. Laya MD MPH Dawn E. DeWitt MD MSc 《Journal of general internal medicine》2004,19(5P2):594-598
The World Wide Web creates new challenges and opportunities for medical educators. Prominent among these are the lack of consistent standards by which to evaluate web-based educational tools. We present the instrument that was used to review web-based innovations in medical education submissions to the 2003 Society of General Internal Medicine (SGIM) national meeting, and discuss the process used by the SGIM web-based clinical curriculum interest group to develop the instrument. The 5 highest-ranked submissions are summarized with commentary from the reviewers. 相似文献
82.
Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity.
Jan M Deussing Claudia Kühne Benno Pütz Markus Panhuysen Johannes Breu Mary P Stenzel-Poore Florian Holsboer Wolfgang Wurst 《Journal of cerebral blood flow and metabolism》2007,27(8):1476-1495
Corticotropin-releasing hormone receptor type 1 (CRH-R1)-deficient mice display reduced anxiety-like behavior, a chronic corticosterone deficit, and an impaired neuroendocrine stress response caused by disruption of the hypothalamic-pituitary-adrenocortical (HPA) axis. The molecular substrates and pathways of CRH/CRH-R1-dependent signaling mechanisms underlying the behavioral phenotype as well as the consequences of lifelong glucocorticoid deficit remain largely obscure. To dissect involved neuronal circuitries, we performed comparative expression profiling of brains of CRH-R1 mutant and wild-type mice using our custom made MPIP (Max Planck Institute of Psychiatry) 17k cDNA microarray. Microarray analysis yielded 107 genes showing altered expression levels when comparing CRH-R1 knockout mice with wild-type littermates. A significant proportion of differentially expressed genes was related to control of HPA and hypothalamic-pituitary-thyroid (HPT) axes reflecting not only the disturbance of the HPA axis in CRH-R1 mutant mice but also the interplay of both neuroendocrine systems. The spatial analysis of regulated genes revealed a prevalence for genes expressed in the cerebral microvasculature. This phenotype was confirmed by the successful cross-validation of regulated genes in CRH overexpressing mice. Analysis of the cerebral vasculature of CRH-R1 mutant and CRH overexpressing mice revealed alterations of functional rather than structural properties. A direct role of the CRH/CRH-R1 system was supported by demonstrating Crhr1 expression in the adult murine cerebral vasculature. In conclusion, these data suggest a novel, previously unknown role of the CRH/CRH-R1 system in modulating neurovascular gene expression and function. 相似文献
83.
84.
85.
Johannes Bjornsson John R. Goellner David Eugene Williams Mary V. Scheiber 《Journal of cancer research and clinical oncology》1986,111(3):289-290
Preoperative cytologic examinations were performed on bronchial material from 92 patients with postsurgical (pathologic) stage I (American Joint Committee) adenocarcinoma of the lung. All patients were followed up for at least 5 years or until death; thus, cases of adenocarcinoma metastatic to the lungs were virtually excluded. Only 22 patients (24%) had abnormal preoperative cytologic findings. This low cytologic sensitivity is ascribed to the small size and peripheral location of the tumors. Large lesions of high histologic grades were more likely to have positive preoperative cytologic findings than small, well-differentiated ones. 相似文献
86.
Sabine Maguire Bruce Hunter Lindsay Hunter Jo Richard Sibert Mala Mann Alison Mary Kemp 《Archives of disease in childhood》2007,92(12):1113-1117
INTRODUCTION: A torn labial frenum is widely regarded as pathognomonic of abuse. METHODS: We systematically reviewed the evidence for this, and to define other intra-oral injuries found in physical abuse. Nine studies documented abusive torn labial frena in 27 children and 24 [corrected] were fatally abused: 22 were less than 5 years old. Only a direct blow to the face was substantiated as a mechanism of injury. RESULTS: Two studies noted accidentally torn labial frena, both from intubation. Abusive intra-oral injuries were widely distributed to the lips, gums, tongue and palate and included fractures, intrusion and extraction of the dentition, bites and contusions. CONCLUSIONS: Current literature does not support the diagnosis of abuse based on a torn labial frenum in isolation. The intra-oral hard and soft tissue should be examined in all suspected abuse cases, and a dental opinion sought where abnormalities are found. 相似文献
87.
Summary A variety of methods are now available for the preparation and labelling of viral nucleic acids for use as probes in diagnostic virology. Some of these are assessed including the use of synthetic oligonucleotides in place of molecularly cloned nucleic acids, and alternatives to labelling with radioactive isotopes such as biotin, enzymes and fluorochromes. Dot blot, sandwich, indirect sandwich and in situ hybridization are covered, and examples given of the current use of nucleic acid probes in detection of human viral infections. The potential and limitations of nucleic acid hybridization are discussed in the light of these new methods. 相似文献
88.
M. Mary Konstantareas Peter Hauser Carolyn Lennox Soula Homatidis 《Child psychiatry and human development》1986,17(1):53-65
Existing evidence suggests an excess of winter births in schizophrenia and inconsistent results for other psychiatric conditions. The present study examined seasonal effects of birth among autistic individuals. Results revealed an excess of spring and carly summer births and an underrepresentation of winter and fall births. However, this pattern was obtained only for the male, nonverbal, and lower-functioning autistic subgroup.This project was supported in part by the Ontario Mental Health Foundation Grant #988-84/86. 相似文献
89.
Neuropsychological assessment, neuroimaging, and neuropsychiatric evaluation in pediatric and adult patients with sickle cell disease (SCD)
下载免费PDF全文
![点击此处可从《Neuropsychiatric Disease and Treatment》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Christopher L Edwards Renee Dunn Raynor Miriam Feliu Camela McDougald Stephanie Johnson Donald Schmechel Mary Wood Gary G Bennett Patrick Saurona Melanie Bonner Chante Wellington Laura M DeCastro Elaine Whitworth Mary Abrams Patrick Logue Lekisha Edwards Salutario Martinez Keith E Whitfield 《Neuropsychiatric Disease and Treatment》2007,3(6):705-709
Traditionally, neuropsychological deficits due to Sickle Cell Disease (SCD) have been understudied in adults. We have begun to suspect, however, that symptomatic and asymptomatic Cerebrovascular Events (CVE) may account for an alarming number of deficits in this population. In the current brief review, we critically evaluated the pediatric and adult literatures on the neurocognitive effects of SCD. We highlighted the studies that have been published on this topic and posit that early detection of CVE via neurocognitive testing, neuropsychiatric evaluations, and neuroimaging may significantly reduce adult cognitive and functional morbidities. 相似文献
90.