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排序方式: 共有1211条查询结果,搜索用时 15 毫秒
991.
Claudia Torresi Mariangela Fiori Luigi Bertolotti Matteo Floris Barbara Colitti Monica Giammarioli Silvia Dei Giudici Annalisa Oggiano Maja Malmberg Gian Mario De Mia Sndor Belk Fredrik Granberg 《Transboundary and Emerging Diseases》2020,67(5):1971-1980
African swine fever (ASF) is a highly contagious and lethal viral disease of pigs and wild boars, which is enzootic in many African countries and on the Italian island of Sardinia, where it has been present since 1978. Previous genetic analyses of Sardinian ASF virus (ASFV) isolates have revealed that they all belong to p72 genotype I, with only minor sequence variations. However, these studies examined only a few selected genes. To distinguish between these closely related isolates and better investigate ASFV evolution in Sardinia, we sequenced the complete genomes of 12 Sardinian ASFV isolates collected between 1978 and 2012, and compared them with 47/Ss/2008 and 26544/OG10. Most of the observed changes occurred in a time‐dependent manner; however, their biological significance remains unclear. As a whole, our results demonstrate the remarkable genetic stability of these strains, supporting a single‐source introduction of the virus. 相似文献
992.
Peroxisome proliferator activated receptor‐gamma stimulation for prevention of 5‐fluorouracil‐induced oral mucositis in mice
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Mariangela Sottili PhD Monica Mangoni MD PhD Chiara Gerini MS Giulia Salvatore PhD Francesca Castiglione MD Isacco Desideri MD Pierluigi Bonomo MD Icro Meattini MD Daniela Greto MD Mauro Loi MD Giulio Francolini MD Marco Perna MD Roberta Grassi MD Giampaolo Biti MD Lorenzo Livi MD 《Head & neck》2018,40(3):577-583
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High density of CD68+/CD163+ tumour‐associated macrophages (M2‐TAM) at diagnosis is significantly correlated to unfavorable prognostic factors and to poor clinical outcomes in patients with diffuse large B‐cell lymphoma
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995.
Inhibition of Cancer Cell Proliferation and Antiradical Effects of Decoction,Hydroalcoholic Extract,and Principal Constituents of Hemidesmus indicus R. Br.
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Giancarlo Statti Mariangela Marrelli Filomena Conforti Antonella Spagnoletti Massimo Tacchini Carmela Fimognari Eleonora Brognara Roberto Gambari Gianni Sacchetti Alessandra Guerrini 《Phytotherapy research : PTR》2015,29(6):857-863
Indian Sarsaparilla (Hemidesmus indicus R. Br.) is widely used in Indian traditional medicine. In the present work, we explored the effects of decoction, traditional Ayurvedic preparation, and hydroalcoholic extract, a phytocomplex more traditionally studied and commercialized as food supplement in western medicine, from the roots as possible source of chemicals with new functional potential linked to their nutritional uses. The antiproliferative and antioxidant properties were assayed. To test antiproliferative affects, different cancer cell lines, growing both as monolayers (CaCo2, MCF‐7, A549, K562, MDA‐MB‐231, Jurkat, HepG2, and LoVo) and in suspension (K562 and Jurkat) were used. The decoction showed strong activity on HepG2 cells, while the hydroalcoholic extracts were active on HepG2, LoVo, MCF‐7, K562, and Jurkat cell lines. Weak inhibition of cancer cell proliferation was observed for the principal constituents of the preparations: 2‐hydroxy‐4‐methoxybenzaldehyde, 2‐hydroxy‐4‐methoxybenzoic acid, and 3‐hydroxy‐4‐methoxybenzaldehyde that were tested alone. The antiradical activity was tested with 2,2‐diphenyl‐1‐picrylhydrazyl and 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid)diammonium salt tests and inhibition of nitric oxide production in lipopolysaccharide‐stimulated RAW 264.7 macrophages. Interesting result has also been obtained for hydroalcoholic extract regarding genoprotective potential (58.79% of inhibition at 37.5 µg/mL). Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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Gautam Borthakur Herve Dombret Philippe Schafhausen Tim Henrik Brummendorf Nicolas Boissel Elias Jabbour Mariangela Mariani Laura Capolongo Patrizia Carpinelli Cristina Davite Hagop Kantarjian Jorge E. Cortes 《Haematologica》2015,100(7):898-904
Danusertib is a pan-aurora kinase inhibitor with potent activity against Abl kinase including the gatekeeper T315I mutant. A phase 1 dose escalation study of danusertib was conducted in patients with accelerated or blastic phase chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia. Two dosing schedules were studied: schedule A, in which danusertib was given by 3-hour intravenous infusion daily for 7 consecutive days (days 1–7) in a 14-day cycle, and schedule B, in which the danusertib was given by 3-hour intravenous infusion daily for 14 consecutive days (days 1–14) in a 21-day cycle. A total of 37 patients were treated, 29 with schedule A and eight with schedule B. The recommended phase 2 dose for schedule A was 180 mg/m2. Enrollment to schedule B was stopped early because of logistical problems with the frequency of infusions. Febrile neutropenia and mucositis were dose-limiting toxicities in schedule A. Four patients with T315I ABL kinase mutation, all treated with schedule A, responded. Danusertib has an acceptable toxicity profile and is active in patients with Bcr-Abl-associated advanced hematologic malignancies. This study was registered with the European Clinical Trails Data Base (EudraCT number 2007-004070-18). 相似文献
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