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991.
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994.
Chu-Hao Weng Pei-Yin Ho Chia-Chi Tsai Jong-Ming Hsu Marcelo Chen Wun-Rong Lin 《Urological research》2013,41(2):133-136
Extracorporeal shock wave lithotripsy (ESWL) is a widely accepted procedure for urolithiasis. However, the shock waves do not pass through the body without damage. Here, we reported a 57-year-old man who underwent ESWL four times before, and immediately developed acute pancreatitis and peritoneal abscess after ESWL for a right renal stone. Although the possibility of post-ESWL acute pancreatitis is extremely low, urologists must be aware of this vital complication. 相似文献
995.
Jin Hee Park Sung Bin Kim Ho Sik Shin Gu Hee Jung Yeon Soon Jung Hark Rim 《International urology and nephrology》2013,45(2):587-590
The spontaneous and serial rupture of the bilateral Achilles tendons without history of significant trauma is an uncommon complication in long-term hemodialysis (HD) patients. The majority of these patients have additional predisposing factors, such as previous use of fluoroquinolone antibiotics or corticosteroids. In general, this condition is associated with a coexisting systemic disease, including chronic kidney disease (CKD), secondary hyperparathyroidism, systemic lupus erythematosus (SLE), and diabetes mellitus (DM). Here, we report a 46-year-old man who had been undergoing regular HD for 11 years. He developed a spontaneous and consecutive rupture of both Achilles tendons. Based on previous reports of tendon ruptures in uremic patients and on the patient’s lack of corticosteroid or fluoroquinolone use, we believe that secondary hyperparathyroidism was the predisposing factor in this patient. The mechanism seems to be related to a high parathyroid hormone (PTH) level, which results in osteolytic bone resorption at the tendon insertion site. Treatment and prevention of such tendon ruptures include early surgical repair and control of secondary hyperparathyroidism, by use of vitamin D analogs, and total parathyroidectomy, with or without autotransplantation of a parathyroid gland. 相似文献
996.
Background
Regulatory T cells (Tregs) play a pivotal role in the persistence of hepatitis C virus infection. The aim of this study was to evaluate the frequency and function of Tregs in patients with chronic hepatitis C (CHC).Methods
We enrolled 44 CHC patients with elevated alanine aminotransferase (ALT) levels (CH group), 13 CHC patients with persistent normal ALT levels (PNALT group), and 14 age-matched healthy subjects (HS group; controls). Tregs were identified as CD4+, CD25+, and forkhead box P3 (Foxp3)+ T lymphocytes, using three-color fluorescence-activated cell sorting (FACS). The frequency of Tregs was determined by calculating the percentage of CD4+CD25high T cells among CD4 T cells. CD127 and CD45RA were also analyzed for subsets of Tregs. The levels of serum transforming growth factor (TGF)-β and interleukin (IL)-10 in immunosuppressive assays were detected by enzyme-linked immunosorbent assay (ELISA). The immunosuppressive abilities of Tregs were evaluated by measuring their ability to inhibit the proliferation of effector cells.Results
Higher proportions of Tregs were found in the CH and PNALT groups compared with the HS group. The populations of CD127 low/negative and CD45RA negative cells were higher in the CH group than in the PNALT group. The expressions of IL-10 and TGF-β in the CH and PNALT groups were significantly higher than those in the HS group. In addition, the immunosuppressive ability of Tregs from the CH group was increased relative to that in the PNALT and the HS group.Conclusions
CHC patients, irrespective of liver function, had higher frequencies of Tregs than healthy subjects; however, only CHC patients with inflammation showed enhanced immunosuppressive function of Tregs. 相似文献997.
Yu TM Wen MC Li CY Cheng CH Wu MJ Chen CH Chen YH Ho HC Shu KH 《Clinical rheumatology》2012,31(4):705-710
This study was conducted to delineate the frequency of recurrent lupus nephritis in a Chinese kidney transplant cohort and
to estimate its impact on long-term transplant outcomes. A total of 32 lupus transplant patients were enrolled in this study,
and the medical records were retrospectively reviewed. Patients with unexplained graft abnormalities were subjected to allograft
biopsy. Recurrent lupus nephritis was diagnosed by light microscopy, immunofluorescence, and electron microscopy. In addition,
to determine the clinical manifestations of recurrent lupus GN in these patients, serum original systemic lupus erythematosus
disease activity index (SLEDAI) scores while undergoing allograft biopsy were evaluated. In total, six out of 32 patients
(18.8%; mean age, 40.5 ± 9.1 years) were diagnosed as having recurrent lupus nephritis and the mean time at diagnosis was
5.1 ± 4.9 years post-transplantation. According to the International Society of Nephrology/Renal Pathology Society (ISN/RPS)
2003 criteria, three of the six cases (50%) were defined as class I, one was class II, one was class IV, and one was class
III + V. The graft and patient survival rates of recurrent lupus nephritis (n = 6) were not different from those of patients with other diagnostic entities. Although recurrent lupus nephritis was not
uncommon, it did not appear to have a strong negative impact on long-term outcome in Chinese kidney transplant patients. The
recurrence was potentially treatable and should not be precluded for receiving transplantation. 相似文献
998.
Chung JW Lee GH Jeong JY Lee SM Jung JH Choi KD Song HJ Jung HY Kim JH 《Journal of gastroenterology and hepatology》2012,27(3):493-497
Background and Aim: New regimens, including those with new fluoroquinolones, have been developed to overcome the antibiotic resistance of Helicobacter pylori. We aimed to assess the antibiotic resistance rates, as well as the molecular mechanisms of fluoroquinolone resistance, of the clinical isolates obtained in Korea. Methods: The minimal inhibitory concentration (MIC) values of ciprofloxacin, amoxicillin, clarithromycin, metronidazole and tetracycline were determined by the agar dilution method for 185 treatment‐naïve Helicobacter pylori isolates. The resistant strains were evaluated for the presence of point mutations in the quinolone resistance‐determining region (QRDR) of the gyrA and gyrB genes by direct nucleotide sequencing. Results: Twenty‐nine (29/185, 15.7%) of the strains were found to be resistant to ciprofloxacin. The resistance rates to amoxicillin, clarithromycin, metronidazole and tetracycline were 2.2% (four of 185), 10.8% (20 of 185), 30.3% (56 of 185) and 0.5% (one of 185), respectively. The most common mutations in the H. pylori gyrA gene were found at codons corresponding to Asp87 (16/29, 55.2%) and Asn91 (10/29, 34.5%). Conclusions: Primary H. pylori resistance to ciprofloxacin occurred at a high frequency. The fluoroquinolone resistance is most likely mediated through amino acid point mutation in the gyrA gene at Asn87 and Asp91. 相似文献
999.
Hyeong Kug KimYu Jeong Choi MD Ki-Woon KangJin A. Lee MD Se Young ParkSeok-Jae Zeon MD Sang Hyun ParkWon Ho Kim MD Sahng LeeKyung Tae Jung MD Soon Chang Park MD 《The Canadian journal of cardiology》2012
Coronary artery anomalies in patients undergoing coronary angiography are often technically challenging for invasive cardiologists and may delay revascularization time. We report a patient who underwent successful bailout revascularization using dual-source computed tomography after failed emergency angiography. This case emphasizes the utility of dual-source computed tomography, especially in an urgent clinical setting, for allowing interventional cardiologists to rapidly identify and effectively treat the aberrant coronary artery. 相似文献
1000.
Moon JH Lee SJ Lee YJ Kang BW Chae YS Kim JG Suh JS Sohn SK 《Annals of hematology》2012,91(3):367-373
This study analyzed the outcomes of the combination of azacitidine and low-dose cytarabine in patients newly diagnosed with
refractory anemia with excess blast (RAEB). Patients were treated with azacitidine 75 mg/m2 for 7 days subcutaneously and cytarabine 20 mg/m2 intravenously for 7 days every 28 days. The assigned regimen was repeated for two cycles, then the patients treated with
azacytidine alone until progression or allogeneic stem cell transplantation (allo-SCT). Eighteen patients with 5 RAEB-1 and
13 RAEB-2 were enrolled in the current study. After two cycles of the combination therapy, responses were achieved in nine
patients (50.0%): four complete response (CR) (22.2%), one partial response (5.6%), two marrow-CR (11.1%), and two hematologic
improvement (11.1%). Four patients (22.2%) progressed to acute leukemia during two cycles of the combination therapy. The
1-year overall survival (OS) was 87.5% for the early response group (responses at two cycles) and 0% for the late response
group (responses at four cycles, p = 0.042). Plus, the median survival time was 476 days (range, 37–718 days) for the early response group and 221 days (range,
193–249 days) for the late response group. The 1-year OS was 100% for the patients who underwent allo-SCT and 73.4% for those
without allo-SCT. In summary, the combination therapy showed promising response rate when compared to treatment with azacitidine
alone. However, it was limited in terms of preventing leukemic transformation. Allo-SCT would seem to be the only available
treatment that can alter disease progression. 相似文献