Three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients: High rates of adverse events

The consequences of once-weekly rifapentine plus isoniazid for 3 months (3HP) against latent tuberculosis infections in hemodialysis patients have not been studied before. This is the first study to evaluate the safety and tolerability of 3HP in this population and revealed a completion rate of 65.4%. The therapy was not associated with hepatotoxicity, but with high rates of adverse events (69.2%).     

Comparative observation of the effect of electroacupuncture combined with heat-sensitive moxibustion and western medicine for premature ovarian failure

Objective

To compare the clinical efficacy between electroacupuncture combined with heat-sensitive moxibustion and western medicine for treatment of premature ovarian failure.

Treatment of a second maxillary molar with six canals

Variations in the dental anatomy are found in all teeth. Knowledge of these variations, particularly concerning the location and treatment of all canals, is very important for the success of the endodontic therapy. The purpose of this study is to present a clinical case of a maxillary second molar with three palatal canals, two mesio-buccal and one disto-buccal canal. This report serves to remind clinicians that such anatomical variations should be taken into account during endodontic treatment of the maxillary molars.     

Progression of periodontitis in a sample of regular and irregular compliers under maintenance therapy: a 3-year follow-up study

Background: To our knowledge, prospective studies (matched for sex, smoking, and diabetes) that investigated the influence of compliance in the progression of periodontitis and tooth loss in periodontal maintenance therapy (PMT) programs were not previously reported. Methods: A total of 58 regular complier (RC) and 58 erratic complier (EC) individuals were recruited from a prospective cohort with 238 patients under PMT and matched by sex, diabetes, and smoking habits. A full‐mouth periodontal examination that included bleeding on probing (BOP), probing depths (PDs), clinical attachment levels, and number of teeth were determined at all PMT visits during a 3‐year interval. The influence of variables of interest was tested through multivariate logistic regression. Results: The progression of periodontitis and tooth loss was significantly lower among RC compared to EC patients. A higher progression of periodontitis was observed among EC patients who smoked. The final logistic model for the progression of periodontitis in the RC group included smoking (odds ratio [OR]: 4.2) and >30% of sites with BOP (OR: 2.8), and the final logistic model for the progression of periodontitis in the EC group included smoking (OR: 7.3), >30% of sites with BOP (OR: 3.2), PDs of 4 to 6 mm in 10% of sites (OR: 3.5), diabetes (OR: 1.9), and number of lost teeth (OR: 3.1). Conclusions: RC patients presented a lower progression of periodontitis and tooth loss compared to EC patients. This result highlighted the influence of the pattern of compliance in maintaining a good periodontal status. Moreover, important risk variables such as smoking and diabetes influenced the periodontal status and should be considered when determining the risk profile and interval time for PMT visits.     

Effect of the adhesive application mode and fiber post translucency on the push-out bond strength to dentin

This study evaluated the effect of the adhesive application mode and fiber post translucency on the push-out bond strength to dentin. Bovine roots were endodontically treated, and 10 roots were used for each adhesive application mode: PB (Prime&Bond 2.1), PB + SC (Self-cure activator), PB + SBM (Scotchbond Multi-purpose adhesive system), BB (Brush&Bond), BB + CAT (chemical catalyst), and BB + SBM. The translucent Light-Post and Aestheti-Post were cemented. The roots/cemented posts were transversally sectioned to originate three thirds (cervical, middle, and apical). The push-out test was performed, and the failure mode of fractured specimens was analyzed. There was no difference between the fiber posts. For PB and BB, the use of hydrophobic adhesive resin SBM increased post bond strength. The use of SC and CAT catalyst did not affect the push-out bond strength values. The apical third presented the lowest bond strengths.     

口腔鳞癌手术后中药治疗远期疗效观察

作者曾对２３８例口腔鳞癌术后应用中药“参阳”方的疗效进行前瞻性的研究,本文继续对已生存４～８年的５６例病员门诊随访结果进行分析．结果是生存情况：７年生存期原治疗组高于原对照组１２．５％,原治疗组３０例均健在,而原对照组中的２６例,２例带瘤生存,１例死亡;Ｔ细胞亚群测定中,复发死亡者的ＣＤ８值均升高,ＣＤ４／ＣＤ８比值均下降;中医辨证中,正常者及肾气虚者的例数以治疗组为多,而阴虚与气阴两虚者,治疗组低于对照组;由上提示：经“参阳”方治疗者有较好的远期疗效．