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排序方式: 共有1374条查询结果,搜索用时 15 毫秒
71.
Nancy H. McGibbon MS FT Carla-Krystin Andrade PhD PT Gail Widener PhD PT Holly Lea Cintas PhD PT PCS 《Developmental medicine and child neurology》1998,40(11):754-762
The purpose of this study was to evaluate the effects of an 8-week program of hippotherapy on energy expenditure during walking; on the gait dimensions of stride length, velocity, and cadence; and on performance on the Gross Motor Function Measure (GMFM) in five children with spastic cerebral palsy (CP). A repeated-measures within-subjects design was used consisting of two baseline measurements taken 8 weeks apart, followed by an 8-week intervention period, then a posttest. After hippotherapy, all five children showed a significant decrease (Xr 2 ;=7.6, P<0.05) in energy expenditure during walking and a significant increase (Xr 2 =7.6, P<0.05) in scores on Dimension E (Walking, Running, and Jumping) of the GMFM. A trend toward increased stride length and decreased cadence was observed. This study suggests that hippotherapy may improve energy expenditure during walking and gross motor function in children with CP. 相似文献
72.
Anne M. Connolly MD Elizabeth C. Malkus PT MHS Jerry R. Mendell MD Kevin M. Flanigan MD J. Philip Miller PhD Jeanine R. Schierbecker PT MHS Catherine A. Siener PT MHS Paul T. Golumbek MD PhD Craig M. Zaidman MD Craig M. Mcdonald MD Linda Johnson PT Alina Nicorici BS Peter I. Karachunski MD John W. Day MD PhD Jason M. Kelecic DPT Linda P. Lowes PT PhD Lindsay N. Alfano PT DPT Basil T. Darras MD Peter B. Kang MD Janet Quigley PT PCS Amy E. Pasternak PT DPT Julaine M. Florence PT DPT MDA DMD Clinical Research Network 《Muscle & nerve》2015,51(4):522-532
Introduction: Therapeutic trials in Duchenne muscular dystrophy (DMD) often exclude non‐ambulatory individuals. Here we establish optimal and reliable assessments in a multicenter trial. Methods: Non‐ambulatory boys/men with DMD (N = 91; 16.7 ± 4.5 years of age) were assessed by trained clinical evaluators. Feasibility (percentage completing task) and reliability [intraclass correlation coefficients (ICCs) between morning and afternoon tests] were measured. Results: Forced vital capacity (FVC), assessed in all subjects, showed a mean of 47.8 ± 22% predicted (ICC 0.98). Brooke Upper Extremity Functional Rating (Brooke) and Egen Klassifikation (EK) scales in 100% of subjects showed ICCs ranging from 0.93 to 0.99. Manual muscle testing, range of motion, 9‐hole peg test, and Jebsen‐Taylor Hand Function Test (JHFT) demonstrated varied feasibility (99% to 70%), with ICCs ranging from 0.99 to 0.64. We found beneficial effects of different forms of corticosteroids for the Brooke scale, percent predicted FVC, and hand and finger strength. Conclusions: Reliable assessment of non‐ambulatory boys/men with DMD is possible. Clinical trials will have to consider corticosteroid use. Muscle Nerve 51: 522–532, 2015 相似文献
73.
Elena Mazzone PT Jacqueline Montes PT MA Marion Main MA Anna Mayhew PT PhD Danielle Ramsey PT Allan M. Glanzman PT DPT Sally Dunaway PT DPT Rachel Salazar PT Amy Pasternak PT Janet Quigley PT Marika Pane MD PhD Maria C. Pera MD Mariacristina Scoto MD Sonia Messina MD PhD Maria Sframeli MD Adele D'amico MD PhD Marleen Van Den Hauwe PT Serena Sivo MD Nathalie Goemans MD Basil T. Darras MD Petra Kaufmann MD MSc Enrico Bertini MD Darryl C. De Vivo MD Francesco Muntoni MD Richard Finkel MD Eugenio Mercuri MD PhD 《Muscle & nerve》2015,52(3):435-437
Introduction: A recent Rasch analysis performed on the Hammersmith Functional Motor Scale—Expanded (HFMSE) in patients with spinal muscular atrophy (SMA) identified issues impacting scale validity, redundant items, and disordered thresholds on some items. Methods: We modified the HMFSE scoring based on the Rasch analysis and on expert consensus to establish whether the traditional scoring overestimated the number of patients with changes within 2 points from baseline. Data were collected retrospectively from multicenter data sets in 255 type 2 and 3 SMA patients. Results: The mean 12‐month changes using the new and the traditional scoring system did not differ significantly (P > 0.05). The numbers of patients who improved or decreased by >2 points were also similar. Conclusions: The presence of outliers using the traditional scoring system was not due to overestimation of changes in activities that were tested bilaterally or to discrepancies in the scoring hierarchy of individual items. Muscle Nerve 52:435–437, 2015 相似文献
74.
Multicenter prospective longitudinal study of magnetic resonance biomarkers in a large duchenne muscular dystrophy cohort 下载免费PDF全文
Rebecca J. Willcocks PhD William D. Rooney PhD William T. Triplett BSc Sean C. Forbes PhD Donovan J. Lott PT PhD Claudia R. Senesac PT PhD Michael J. Daniels ScD Dah‐Jyuu Wang PhD Ann T. Harrington PT PhD Gihan I. Tennekoon MD Barry S. Russman MD Erika L. Finanger MD Barry J. Byrne MD PhD Richard S. Finkel MD Glenn A. Walter PhD H. Lee Sweeney PhD Krista Vandenborne PT PhD 《Annals of neurology》2016,79(4):535-547
75.
Electrical impedance myography in individuals with collagen 6 and laminin α‐2 congenital muscular dystrophy: a cross‐sectional and 2‐year analysis 下载免费PDF全文
Carmel Nichols BA Minal S. Jain PT DSc PCS Katherine G. Meilleur PhD Tianxia Wu PhD James Collins MD PhD Melissa R. Waite MSPT Jahannaz Dastgir DO Anam Salman MD Sandra Donkervoort MS CGC Tina Duong MPT PhD Katherine Keller MSPT Meganne E. Leach MSN Donovan J. Lott PT PhD Michelle N. McGuire PT MPT Leslie Nelson MPT Anne Rutkowski MD Carole Vuillerot MD PhD Carsten G. Bönnemann MD Tanya J. Lehky MD 《Muscle & nerve》2018,57(1):54-60
76.
77.
Matthew Bancone BS Alessandra Sacco PhD Kirkwood E. Personius PT PhD 《Muscle & nerve》2016,54(4):763-768
Introduction: Duchenne muscular dystrophy (DMD) is caused by loss of the structural protein, dystrophin, resulting in muscle fragility. Muscle stem cell (MuSC) transplantation is a potential therapy for DMD. It is unknown whether donor‐derived muscle fibers are structurally innervated. Methods: Green fluorescent protein (GFP)–expressing MuSCs were transplanted into the tibials anterior of adult dystrophic mdx/mTR mice. Three weeks later the neuromuscular junction was labeled by immunohistochemistry. Results: The percent overlap between pre‐ and postsynaptic immunolabeling was greater in donor‐derived GFP+ myofibers, and fewer GFP+ myofibers were identified as denervated compared with control GFP– fibers (P = 0.001 and 0.03). GFP+ fibers also demonstrated acetylcholine receptor fragmentation and expanded endplate area, indicators of muscle reinnervation (P = 0.008 and 0.033). Conclusion: It is unclear whether GFP+ fibers are a result of de novo synthesis or fusion with damaged endogenous fibers. Either way, donor‐derived fibers demonstrate clear histological innervation. Muscle Nerve 54 : 763–768, 2016 相似文献
78.
The quality of life in genetic neuromuscular disease questionnaire: Rasch validation of the French version 下载免费PDF全文
Antoine Dany PT PhD Amandine Rapin MD MSc Brice Lavrard MD Virginie Saoût MD Christian Réveillère PhD Guillaume Bassez MD PhD Vincent Tiffreau MD PhD Yann Péréon MD PhD Sabrina Sacconi MD PhD Bruno Eymard MD PhD Moustapha Dramé MD PhD Damien Jolly MD PhD Jean‐Luc Novella MD PhD Jean‐Benoit Hardouin PhD François C. Boyer MD PhD 《Muscle & nerve》2017,56(6):1085-1091
79.
Sharron Rushton DNP MS RN CCM CNE Allison A. Lewinski PhD MPH RN Soohyun Hwang MPH Leah L. Zullig PhD Katharine A. Ball Ricks PhD MPH MS Katherine Ramos PhD Adelaide Gordon MPH Belinda Ear MPH Lindsay A. Ballengee PT DPT Mulugu V. Brahmajothi MSc PhD MHS Thomasena Moore DNP MHA RN CPHQ Dan V. Blalock PhD John W. Williams Jr MD MHS Sarah E. Cantrell MLIS AHIP Jennifer M. Gierisch PhD MPH Karen M. Goldstein MD MSPH 《Journal of clinical nursing》2023,32(1-2):3-30
80.
Test–retest Reliability in Reporting the Pain Induced by a Pain Provocation Test: Further Validation of a Novel Approach for Pain Drawing Acquisition and Analysis 下载免费PDF全文