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941.
Candice Alexandra Grzelak Luciano Gastón Martelotto Nicholas David Sigglekow Bramilla Patkunanathan Katerina Ajami Sarah Ruth Calabro Benjamin James Dwyer Janina Elke Eleonore Tirnitz-Parker D. Neil Watkins Fiona Jane Warner Nicholas Adam Shackel Geoffrey William McCaughan 《Journal of hepatology》2014
942.
To determine the effects of age and sex on in vivo mitochondrial function of distinct locomotory muscles, the tibialis anterior (TA) and medial gastrocnemius (MG), of young (Y; 24 ± 3 years) and older (O; 69 ± 4) men (M) and women (W) of similar overall physical activity (PA) was compared. In vivo mitochondrial function was measured using phosphorus magnetic resonance spectroscopy, and PA and physical function were measured in all subjects. Overall PA was similar among the groups, although O (n = 17) had fewer daily minutes of moderate-to-vigorous PA (p = 0.001), and slowed physical function (p < 0.05 for all variables), compared with Y (n = 17). In TA, oxidative capacity (Vmax; mM s−1) was higher in O than Y (p < 0.001; Y = 0.90 ± 0.12; O = 1.12 ± 0.18). There was no effect of age in MG (p = 0.5; Y = 0.91 ± 0.17; O = 0.96 ± 0.24), but women had higher oxidative capacity than men (p = 0.007; M = 0.84 ± 0.18; W = 1.03 ± 0.18). In vivo mitochondrial function was preserved in healthy O men and women, despite lower intensity PA and physical function in this group. The extent to which compensatory changes in gait may be responsible for this preservation warrants further investigation. Furthermore, women had higher oxidative capacity in the MG, but not the TA. 相似文献
943.
Prof Michael Manns Prof Patrick Marcellin Prof Fred Poordad Evaldo Stanislau Affonso de Araujo Prof Maria Buti Prof Yves Horsmans Ewa Janczewska Prof Federico Villamil Jane Scott Monika Peeters Oliver Lenz Sivi Ouwerkerk-Mahadevan Guy De La Rosa Ronald Kalmeijer Rekha Sinha Maria Beumont-Mauviel 《Lancet》2014
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948.
Elizabeth J. Baker Nancy A. Beck Ellen L. Berg Helene D. Clayton-Jeter P. Charukeshi Chandrasekera J. Lowry Curley Bruce A. Donzanti Lorna C. Ewart Jane M. Gunther J. Gerry Kenna Edward L. LeCluyse Michael N. Liebman Catherine L. Pugh Paul B. Watkins Kristie M. Sullivan 《Drug discovery today》2019,24(2):624-628
949.
Jane Mohler Karen D’Huyvetter Lisa O’Neill Conrad Clemens Amy Waer Victoria Began 《Gerontology & geriatrics education》2014,35(4):354-368
Using interprofessional faculty, the authors reviewed and enhanced the nationally renowned Chief Resident Immersion Training (CRIT) in the Care of Older Adults Program to include Triple Aim objectives and interprofessional competency-based content and developed the Interprofessional CRIT. Evaluations were positive and sustained. The authors educated chief residents about value-based care, linking them to key interprofessional staff to build team-based care. The authors addressed quality improvement issues identified by the Institute of Medicine and our health network. Chief residents are now better prepared to train medical students and residents using a team-based, patient-centered approach, and a culture of continual quality improvement toward improved care of older patients. 相似文献
950.
A phase III randomized trial of high‐dose CEOP + filgrastim versus standard‐dose CEOP in patients with non‐Hodgkin lymphoma: 10‐year follow‐up data: Australasian Leukaemia and Lymphoma Group (ALLG) NHL07 trial 下载免费PDF全文
Mark Hertzberg Jane Palfrey Matthews Janey Malka Stone Ming‐Celine Dubosq Andrew Grigg David Ellis Warwick Benson Peter Browett Noemi Horvath Henry Januszewicz Ehtesham Abdi Michael Green Anthony Bonaventura Paula Marlton Paul Cannell Max Wolf 《American journal of hematology》2014,89(5):536-541
Increasing dose intensity (DI) of chemotherapy for patients with aggressive non‐Hodgkin lymphoma (NHL) may improve outcomes at the cost of increased toxicity. This issue was addressed in a randomized trial aiming to double the DI of myelosuppressive drugs. Between 1994 and 1999, 250 patients with previously untreated aggressive NHL were randomized to treatment with six cycles of 3‐weekly standard (s) or intensive (i) chemotherapy: s‐CEOP–cyclophosphamide 750, epirubicin 75, vincristine 1.4 mg/m2 all on day 1, and prednisolone 100 mg days 1–5; i‐CEOP–cyclophosphamide 1,500, epirubicin 150, vincristine 1.4 mg/m2 all on day 1, and prednisolone 100 mg days 1–5. Primary endpoint was 5‐year overall survival (OS). Relative to s‐CEOP patients, i‐CEOP patients achieved a 78% increase in the DI of cyclophosphamide and epirubicin. Despite this, there was no significant difference in any outcome: 5‐year OS (56.7% i‐CEOP; 55.1% s‐CEOP; P = 0.80), 5‐year progression free survival (PFS; 41% i‐CEOP; 43% s‐CEOP; P = 0.73), 5‐year time to progression (TTP; 44% i‐CEOP; 47% s‐CEOP; P = 0.72), or complete remission (CR) + unconfirmed CR (CRu) rates (53% i‐CEOP; 59% s‐CEOP; P = 0.64). Long‐term follow up at 10 years also showed no significant differences in OS, PFS, or TTP. The i‐CEOP arm had higher rates of febrile neutropenia (70 vs. 26%), hospitalisations, blood product utilisation, haematological and gastrointestinal toxicities, and lower quality of life scores during treatment, although without significant differences 6‐month later. In the treatment of aggressive NHL in the prerituximab era, increasing DI did not result in improved outcomes, while at the same time lead to increased toxicity. Am. J. Hematol. 89:536–541, 2014. © 2014 Wiley Periodicals, Inc. 相似文献