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排序方式: 共有201条查询结果,搜索用时 672 毫秒
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JF Correia‐Silva O Bruna‐Romero RG Resende LPM Miranda FE Oliveira FO Costa SG Xavier SP Figueiredo‐Neves HC Almeida H Bittencourt RS Gomez 《Oral diseases》2010,16(2):210-216
Oral Diseases (2010) 16 , 210–216 Objective: The purpose of this study was to investigate the use of saliva for the identification of human cytomegalovirus (HCMV) in allogeneic hematopoietic stem cell transplant patients by real time PCR compared with blood. Materials and methods: Saliva and blood samples were sampled weekly in 30 allogeneic hematopoietic stem cell transplant patients until 100 days after transplant. Total genomic DNA, extracted from saliva and whole‐blood samples, was used for HCMV real time PCR. Nonparametric tests were performed, and P value ≤0.05 was considered statistically significant. Results: Human cytomegalovirus DNA load in saliva showed a high correlation with viral DNA in the blood ( R = 0.858; P < 0.0001). Blood DNA levels also correlated with HCMV antigenemia ( R = 0.773; P < 0.0001). The HCMV levels in saliva ( P = 0.015) and blood ( P = 0.008) showed higher levels at the beginning of antiviral treatment, with clear reduction after this period. Saliva showed earlier HCMV reactivation than blood detected by real time PCR and antigenemia assay in 11 out of 22 subjects. Conclusions: This study shows that the real time PCR test could be useful to identify HCMV DNA in saliva and to monitor patients at risk of cytomegalovirus disease after allogeneic hematopoietic stem cell transplant. However, further studies are necessary to confirm this data. 相似文献
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AO Fawole A Shah AO Fabanwo O Adegbola AA Adewunmi AB Eniayewun K Dara AM El-Ladan AC Umezulike FE Alu AA Adebayo FO Obaitan OE Onala Y Usman AO Sullayman S Kailani M Sa'id 《African health sciences》2012,12(1):32-40
Background
Maternal mortality in poor countries reflects the under-development in these societies. Global recognition of the burden of maternal mortality and the urgency for a reversal of the trend underpin the Millenium Development Goals (MDGs).Objective
To determine risk factors for maternal mortality in institutional births in Nigeria.Method
Twenty one health facilities in three states were selected using stratified multi-stage cluster sampling strategy. Information on all delivered mothers and their newborn infants within a three-month period was culled from medical records.Results
A total of 9 208 deliveries were recorded. About one-fifth (20.5%) of women had no antenatal care while 79.5% had at least one antenatal visit during pregnancy. Four-fifths (80.5%) of all deliveries were normal deliveries. Elective and emergency caesarean section rates were 3.1% and 11.5% respectively. There were 79 maternal deaths and 8 526 live births, giving a maternal mortality ratio of 927 maternal deaths per 100 000 live births. No antenatal care, parity, level of education, and mode of delivery were significantly associated with maternal mortality. Low maternal education, high parity, emergency caesarean delivery, and high risk patients risk independently predicted maternal mortality.Conclusion
Meeting goal five of the MDGs remains a major challenge in Nigeria. Multi-sectoral approaches and focused political will are needed to revert the high maternal mortality. 相似文献97.
Investigation of the relative infectivity and pathogenicity of different hepatitis C virus genotypes in hemophiliacs 总被引:1,自引:0,他引:1
Jarvis LM; Ludlam CA; Ellender JA; Nemes L; Field SP; Song E; Chuansumrit A; Preston FE; Simmonds P 《Blood》1996,87(7):3007-3011
To assess the relative infectivity and pathogenicity of variants of hepatitis C virus (HCV) genotypes, the distribution of genotypes in hemophilic patients who had been treated with nonvirally inactivated factor concentrates or cryoprecipitates prepared from local blood donors was compared with those found in the respective blood donor populations. Genotype frequencies differed markedly in the four countries investigated (Scotland, Hungary, South Africa, and Thailand) but in each, the HCV genotype distributions in hemophiliacs and blood donors were similar. In addition, HCV genotypes in recipients of commercially manufactured concentrates were similar to those found in the US general population. These findings provide no evidence that HCV genotypes differ significantly from each other in replication rate, transmissibility, or infectivity. 相似文献
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Antibiotic resistance presents a daunting challenge to health professionals worldwide and has the potential to create major problems for modern health care, resulting in more medical expenditure, extended hospital stays and increased morbidity and mortality. Advanced genome sequencing technologies present a complex picture of resistance, extending our understanding beyond the pharmacotherapeutic interface between pathogens and antibiotics. This review discusses the global scope and scale of antibiotic resistance and contextualizes it for the dental practitioner, emphasizing the role we must play in limiting the progression of resistance through antibiotic stewardship and disease prevention. 相似文献
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