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21.
Karen Elcock BSc RN Cert Ed FE 《Journal of advanced nursing》1998,28(5):1092-1098
Lecturer practitioner: a concept analysis ¶ The concept of the lecturer practitioner arose in one health authority in Britain in the late 1980s. Since its inception there, the concept has been widely adopted across the country suggesting that there is a perceived need for this role. However, there is much confusion over what a lecturer practitioner is, since each post is multifaceted, complex and unique. Rodgers' (1993) evolutionary concept analysis is used in an attempt to clarify and to identify those elements that are common to this concept. Through a review of all the available literature on this concept, the attributes, antecedents and consequences are identified and their implications discussed. Rodgers' evolutionary method is described and critiqued throughout the paper and is shown to be a suitable method for clarifying a complex concept. 相似文献
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普罗布考和抗氧化维生素不影响体外实验条件下内皮细胞的白细胞粘附 总被引:2,自引:2,他引:0
为探讨预防动脉粥样硬化的药物普罗布考,维生素C和维生素E是否抑制内皮细胞表面粘附分子表达和白细胞一内皮细胞的粘附,以及这种抑制是否通过影响核因子-kB的活性来实现的,在液体流动小室中进行细胞粘附实验。用ELISA方法测定内皮细胞粘附分子E-选择素的表达;用电泳迁移率分析测定内皮细胞核因子-kB的活性,经肿瘤坏死因子α刺激的内皮细胞核因子-B活性增加,粘附分子E-选择素的表达上调(是基础水平的3.5倍),其表面HL60细胞的粘附增加(是基础水平的4-26倍),而抗氧化剂PDTC使所有这些变化都受到抑制。PDTC浓度为18umol/L时对粘附分子E-选择素的表达呈最大半抑制;PDTC浓度为52umol/L时对内皮细胞表面HL60细胞的粘附呈最大半抑制,普罗布考,维生素C和维生素E对肿瘤坏死因子α诱导的粘附分子表达和HL60细胞与内皮细胞的粘附没有作用,对核因子-kB的活性没有影响,临床上常用的这三种抗氧化剂并未影响作为动脉粥样硬化始动机制之一的E-选择素介导的白细胞-内皮细胞粘附水平。 相似文献
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Philomena J Calpm-Davies RN RM RNT DipN Cert FE BEd MBA 《Journal of advanced nursing》1996,24(4):800-809
The British National Health Service is proposing to establish local consortia for educational contracting, with the wider involvement and responsibility being devolved to service providers This paper addresses the economic considerations of purchasing post-qualifying professional education in the English hospital sector, for hospital nurses, doctors and physiotherapists in England 相似文献
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Gulley ML; Eagan PA; Quintanilla-Martinez L; Picado AL; Smir BN; Childs C; Dunn CD; Craig FE; Williams JW Jr; Banks PM 《Blood》1994,83(6):1595-1602
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Heterogeneity of hepatitis C virus genotypes in hemophilia: relationship with chronic liver disease 总被引:2,自引:0,他引:2
Preston FE; Jarvis LM; Makris M; Philp L; Underwood JC; Ludlam CA; Simmonds P 《Blood》1995,85(5):1259-1262
In this study we have determined the hepatitis C virus (HCV) serotype and genotype in a cohort of 96 HCV-infected hemophiliacs and have examined the relationship between HCV genotype and severity of chronic liver disease as determined by liver biopsy. HCV serotype was determined by specific enzyme-linked immunosorbent assays (ELISAs) and genotype by restriction fragment length polymorphism (RFLP) and HCV viral sequencing. The pattern of genotype distribution was quite unlike that of HCV-infected United Kingdom (UK) blood donors in that five of the six known HCV genotypes were represented, 50% were type 1, 13% type 2, and 18% type 3. An unexpected observation was the presence of HCV genotype 4 in four patients and type 5 in two patients. An additional feature was the presence of mixed infection, detected in 14% and 7% by serotype and genotype analysis, respectively. Liver biopsies were available from 51 patients. Cirrhosis was present in five of 27 (19%) of individuals with type 1, in 2 of 9 (22%) with type 2, and 5 of 8 (63%) of those with type 3. The heterogeneous pattern of HCV genotype distribution in this cohort of patients and the observed relationship between the severity of the related liver disease and specific HCV genotype may have important implications with respect to the natural history and treatment of HCV-related chronic liver disease in infected hemophiliacs worldwide. 相似文献