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951.
952.
反相高效液相色谱法测定甲磺酸酚妥拉明片的含量 总被引:4,自引:0,他引:4
目的:建立了反向高效液相色谱法测定甲磺酸酚妥拉明的含量的方法。方法:采用Symmetry C18硅烷键和硅胶柱,甲醇-水-冰醋酸-三乙胺(10:10:1:0.1)作为流动相,检测波长为278nm,峰面积外标法测定。结果:平均回收率为100.2%(n=11),日内、日间差分别为0.7%和0.8%,在10-250μg范围内线性关系良好(r=0.9999),结论:该法简便、准确、结果满意。 相似文献
953.
Atara Posner Owen WJ Prall Tharani Sivakumaran Dariush Etemadamoghadam Niko Thio Andrew Pattison Shiva Balachander Krista Fisher Samantha Webb Colin Wood Anna DeFazio Nicholas Wilcken Bo Gao Christos S Karapetis Madhu Singh Ian M Collins Gary Richardson Christopher Steer Mark Warren Narayan Karanth Gavin Wright Scott Williams Joshy George Rodney J Hicks Alex Boussioutas Anthony J Gill Benjamin J Solomon Huiling Xu Andrew Fellowes Stephen B Fox Penelope Schofield David Bowtell Linda Mileshkin Richard W Tothill 《The Journal of pathology》2023,259(1):81-92
Cancer of unknown primary (CUP) is a syndrome defined by clinical absence of a primary cancer after standardised investigations. Gene expression profiling (GEP) and DNA sequencing have been used to predict primary tissue of origin (TOO) in CUP and find molecularly guided treatments; however, a detailed comparison of the diagnostic yield from these two tests has not been described. Here, we compared the diagnostic utility of RNA and DNA tests in 215 CUP patients (82% received both tests) in a prospective Australian study. Based on retrospective assessment of clinicopathological data, 77% (166/215) of CUPs had insufficient evidence to support TOO diagnosis (clinicopathology unresolved). The remainder had either a latent primary diagnosis (10%) or clinicopathological evidence to support a likely TOO diagnosis (13%) (clinicopathology resolved). We applied a microarray (CUPGuide) or custom NanoString 18-class GEP test to 191 CUPs with an accuracy of 91.5% in known metastatic cancers for high–medium confidence predictions. Classification performance was similar in clinicopathology-resolved CUPs – 80% had high–medium predictions and 94% were concordant with pathology. Notably, only 56% of the clinicopathology-unresolved CUPs had high–medium confidence GEP predictions. Diagnostic DNA features were interrogated in 201 CUP tumours guided by the cancer type specificity of mutations observed across 22 cancer types from the AACR Project GENIE database (77,058 tumours) as well as mutational signatures (e.g. smoking). Among the clinicopathology-unresolved CUPs, mutations and mutational signatures provided additional diagnostic evidence in 31% of cases. GEP classification was useful in only 13% of cases and oncoviral detection in 4%. Among CUPs where genomics informed TOO, lung and biliary cancers were the most frequently identified types, while kidney tumours were another identifiable subset. In conclusion, DNA and RNA profiling supported an unconfirmed TOO diagnosis in one-third of CUPs otherwise unresolved by clinicopathology assessment alone. DNA mutation profiling was the more diagnostically informative assay. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 相似文献
954.
- • In 2004 there was an international conference at the Open University about the history of self‐advocacy. Self‐advocates and their supporters came from many different countries.
- • This issue of the journal is a collection of papers from that conference.
- • The papers tell how self‐advocacy is taking place in different countries.
- • Together the papers give a bigger picture of self‐advocacy and show how people in different countries are often dealing with similar issues.