远端与近端结肠癌在临床、病理和分子生物学特征上的区别

背景远端和近端结肠癌在起源,基因暴露,环境诱变及肠道菌群等方面均存在差异。然而这些差异很少被用来解释如何影响肿瘤的发生机制,特异的治疗响应及预后情况。研究系统性探索了远端与近端结肠癌的差异及这些差异的临床意义。资料与方法研究共纳入3 045例结肠癌患者的详细临床病理数据用于分析,这些患者资料均来源于PETACC3(关于结肠癌辅助化疗)临床试验。这些数据中,     

Intubation for patients with overdose: Time to move on from the Glasgow Coma Scale

Patients frequently present to the ED with drug overdose and reduced conscious level leading to coma. There is considerable practice variation around which patients require intubation. Indications include: (i) respiratory failure (including airway obstruction); (ii) to facilitate specific therapies or intubation as a therapy in itself; and (iii) for airway protection in the unprotected airway. We argue that intubating a patient purely for (iii) is outdated and that most patients can be safely observed. There is a paucity of good quality research in the area of drug overdose with reduced consciousness. Teaching may be outdated and based on the use of the Glasgow Coma Scale in head trauma. Current low quality research suggests observation is safe. We recommend that patients undergo an individualised risk assessment of the need for intubation. We propose a flow diagram to aid clinicians in safely observing comatose overdose patients. This can be applied if the drug is unknown, or there are multiple drugs involved.