全文获取类型
收费全文 | 1364973篇 |
免费 | 103867篇 |
国内免费 | 4295篇 |
专业分类
耳鼻咽喉 | 17123篇 |
儿科学 | 44543篇 |
妇产科学 | 37015篇 |
基础医学 | 202790篇 |
口腔科学 | 36141篇 |
临床医学 | 132459篇 |
内科学 | 265453篇 |
皮肤病学 | 27012篇 |
神经病学 | 114868篇 |
特种医学 | 49114篇 |
外国民族医学 | 390篇 |
外科学 | 188112篇 |
综合类 | 28833篇 |
现状与发展 | 1篇 |
一般理论 | 465篇 |
预防医学 | 116506篇 |
眼科学 | 29518篇 |
药学 | 100992篇 |
6篇 | |
中国医学 | 3230篇 |
肿瘤学 | 78564篇 |
出版年
2021年 | 11352篇 |
2019年 | 12128篇 |
2018年 | 17239篇 |
2017年 | 12940篇 |
2016年 | 13897篇 |
2015年 | 16006篇 |
2014年 | 21623篇 |
2013年 | 33337篇 |
2012年 | 46557篇 |
2011年 | 49150篇 |
2010年 | 28153篇 |
2009年 | 25771篇 |
2008年 | 44769篇 |
2007年 | 47173篇 |
2006年 | 47152篇 |
2005年 | 45666篇 |
2004年 | 43570篇 |
2003年 | 41348篇 |
2002年 | 40079篇 |
2001年 | 61612篇 |
2000年 | 63319篇 |
1999年 | 52927篇 |
1998年 | 14726篇 |
1997年 | 13377篇 |
1996年 | 13222篇 |
1995年 | 12550篇 |
1994年 | 11719篇 |
1993年 | 10992篇 |
1992年 | 41978篇 |
1991年 | 41109篇 |
1990年 | 39793篇 |
1989年 | 37686篇 |
1988年 | 34884篇 |
1987年 | 34003篇 |
1986年 | 32403篇 |
1985年 | 30889篇 |
1984年 | 23223篇 |
1983年 | 19729篇 |
1982年 | 11842篇 |
1979年 | 20928篇 |
1978年 | 14893篇 |
1977年 | 12143篇 |
1976年 | 11944篇 |
1975年 | 12174篇 |
1974年 | 14899篇 |
1973年 | 14554篇 |
1972年 | 13445篇 |
1971年 | 12511篇 |
1970年 | 11570篇 |
1969年 | 10511篇 |
排序方式: 共有10000条查询结果,搜索用时 453 毫秒
41.
M.F. Werner A. López-Rueda F.X. Zarco J. Blasco L. San Román S. Amaro E. Carrero R. Valero L. Oleaga J.M. Macho N. Bargalló 《Radiologia》2019,61(2):143-152
Purpose
Endovascular treatment with mechanical thrombectomy devices demonstrated high recanalization rates but functional outcome did not correlate with high rates of recanalization obtained. Patient selection prior to the endovascular treatment is very important in the final outcome of the patient. The primary aim of our study was to evaluate the prognostic value of posterior circulation Alberta Stroke Program Early CT Score (pc-ASPECTS) and Pons-Midbrain Index (PMI) scores in patients with Basilar Artery Occlusion (BAO) treated with successful angiographic recanalization after mechanical thrombectomy.Methods
Retrospective single-center study including 18 patients between 2008 and 2013 who had acute basilar artery occlusion managed with endovascular treatment within 24 hours from symptoms onset and with successful angiographic recanalization. The patients were initially classified into two groups according to clinical outcome and mortality at 90 days. For analysis we also divided patients into groups based on pc-ASPECTS (≥8vs.< 8) and PMI (≥3vs.< 3) on non-contrast CT (NCCT) and CT Angiography Source Images (CTASI). Imaging data were correlated to clinical outcome and mortality rate.Results
CTASI pc-ASPECTS, dichotomized at < 8 versus≥8, was associated with a favorable outcome (RR: 2.6; 95% CI: 1.3-5.2) and a reduced risk of death (RR: 6.5: 95% CI: 7.8-23.3). All patients that survived and were functionally independent had pc-ASPECTS score≥8. None of the 5 patients with CTASI pc-ASPECTS score less than 8 survived.Conclusion
PC-ASPECTS on CTASI is helpful for predicting functional outcome after BAO recanalization with endovascular treatment. These results should be validated in a randomized controlled trial in order to decide whether or not to treat a patient with BAO. 相似文献42.
Notfall + Rettungsmedizin - 相似文献
43.
44.
45.
Ali Mobasheri Csaba Matta Ilona Uzielienè Emma Budd Pablo Martín-Vasallo Eiva Bernotiene 《Joint, bone, spine : revue du rhumatisme》2019,86(1):29-35
Chondrocytes are the main cells in the extracellular matrix (ECM) of articular cartilage and possess a highly differentiated phenotype that is the hallmark of the unique physiological functions of this specialised load-bearing connective tissue. The plasma membrane of articular chondrocytes contains a rich and diverse complement of membrane proteins, known as the membranome, which defines the cell surface phenotype of the cells. The membranome is a key target of pharmacological agents and is important for chondrocyte function. It includes channels, transporters, enzymes, receptors, and anchors for intracellular, cytoskeletal and ECM proteins and other macromolecular complexes. The chondrocyte channelome is a sub-compartment of the membranome and includes a complete set of ion channels and porins expressed in these cells. Many of these are multi-functional proteins with “moonlighting” roles, serving as channels, receptors and signalling components of larger molecular assemblies. The aim of this review is to summarise our current knowledge of the fundamental aspects of the chondrocyte channelome, discuss its relevance to cartilage biology and highlight its possible role in the pathogenesis of osteoarthritis (OA). Excessive and inappropriate mechanical loads, an inflammatory micro-environment, alternative splicing of channel components or accumulation of basic calcium phosphate crystals can result in an altered chondrocyte channelome impairing its function. Alterations in Ca2+ signalling may lead to defective synthesis of ECM macromolecules and aggravated catabolic responses in chondrocytes, which is an important and relatively unexplored aspect of the complex and poorly understood mechanism of OA development. 相似文献
46.
47.
48.
49.
50.
Autoimmune comorbid diseases associated with lichen planus: a nationwide case–control study
下载免费PDF全文
![点击此处可从《Journal of the European Academy of Dermatology and Venereology》网站下载免费的PDF全文](/ch/ext_images/free.gif)