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991.
992.
Neither macroscopic nor microscopic lesions were observed in the gastrointestinal mucosa following the surgical removal of Brunner's glands. This observation leaves some doubt concerning the traditional view that Brunner's glands function primarily in the protection of the proximal duodenal mucosa from acid-pepsin entering from the stomach. 相似文献
993.
Development of the pituitary in Didelphis follows the general pattern of that described for most mammalian species. The dorsal region of a multichambered pituitary vesicle, which forms from Rathke's pouch, comes to lie adjacent to the presumptive infundibulum by the 10 1/2 d of gestation. The epithelial wall of this vesicle consists of spindle-shaped cells. The dorsal wall of the upper chamber of the pituitary vesicle forms the pars intermedia; the ventral wall of this chamber gives rise to cells of the pars distalis. Corticotropes, somatotropes, and lactotropes are seen in the presumptive adenohypophysis of the 11 1/2 d embryo. Gonadotropes and thyrotropes appear about 1 d later, shortly after birth. By the 2 postnatal week, the adult distribution of all 5 cell types within the pars distalis appears to have been established. The wall bounding the pituitary cleft in the adult represents an epithelial continuum limited by a basal lamina and corresponds to the upper chamber of the original pituitary vesicle. Ultrastructurally, the limiting walls of the pituitary cleft consists of stellate (marginal) cells, large, bulbous cells, and granulated cells. The latter correspond to the various endocrine cell types normally associated with the pars distalis. Non-granular folliculo-stellate cells also are observed within the epithelial cords of the pars distalis. 相似文献
994.
T. Weber G. Schulz J. Beyer H. Geiling U. Cordes C. Diederich U. Krause 《Journal of molecular medicine (Berlin, Germany)》1990,68(19):951-958
Summary The aim of the study was to investigate the influence of 40 mg of the beta-blocker penbutolol (BetapressinTM; Hoechst Ltd., Frankfurt/ Main) in comparison to placebo on the insulin consumption on the blood sugar profile in twelve insulin-dependent diabetes (IDDM) patients. The patients were treated with penbutolol and placebo for a period of three days, and then were examined with the help of the glucose-controlled insulin infusion system.The blood sugar profile and insulin consumption over a 24 hour period was not affected by either penbutolol or placebo, nor could any changes be measured in these parameters when measured after food intake.After a submaximal exercise load on the bicycle ergometer (1 watt per kg body weight) following an evening meal, no difference could be observed between penbutolol and placebo in the above-mentioned parameters. The same was also true for hormonal parameters as STH, ACTH, cortisol, and catecholamines.These findings demonstrated that medication of penbutolol over a three-day period has no influence on the baseline blood sugar profile and insulin consumption or on insulin consumption after food intake during rest and physical exercise.Abbreviations IDDM
insulin-dependent diabetes
- STH
somatotropic hormone
- GH
growth hormone
- ACTH
adrenocorticotropic hormone
- HbA1
glycosylated hemoglobin A1
- mE
milli-units
- SEM
standard error of the mean 相似文献
995.
996.
997.
998.
A. Koy M. Weinsheimer K.A.M. Pauls A.A. Kühn P. Krause J. Huebl G.-H. Schneider G. Deuschl R. Erasmi D. Falk J.K. Krauss G. Lütjens A. Schnitzler L. Wojtecki J. Vesper R. Korinthenberg V.A. Coenen V. Visser-Vandewalle L. Timmermann 《European journal of paediatric neurology》2017,21(1):136-146
Background
Data on paediatric deep brain stimulation (DBS) is limited, especially for long-term outcomes, because of small numbers in single center series and lack of systematic multi-center trials.Objectives
We seek to systematically evaluate the clinical outcome of paediatric patients undergoing DBS.Methods
A German registry on paediatric DBS (GEPESTIM) was created to collect data of patients with dystonia undergoing DBS up to the age of 18 years. Patients were divided into three groups according to etiology (group 1 inherited, group 2 acquired, and group 3 idiopathic dystonia).Results
Data of 44 patients with a mean age of 12.8 years at time of operation provided by 6 German centers could be documented in the registry so far (group 1 n = 18, group 2 n = 16, group 3 n = 10). Average absolute improvement after implantation was 15.5 ± 18.0 for 27 patients with pre- and postoperative Burke-Fahn-Marsden Dystonia Rating scale movement scores available (p < 0.001) (group 1: 19.6 ± 19.7, n = 12; group 2: 7.0 ± 8.9, n = 8; group 3: 19.2 ± 20.7, n = 7). Infection was the main reason for hardware removal (n = 6). 20 IPG replacements due to battery expiry were necessary in 15 patients at 3.7 ± 1.8 years after last implantation.Discussion
Pre- and postoperative data on paediatric DBS are very heterogeneous and incomplete but corroborate the positive effects of DBS on inherited and acquired dystonia. Adverse events including relatively frequent IPG replacements due to battery expiry seem to be a prominent feature of children with dystonia undergoing DBS. The registry enables collaborative research on DBS treatment in the paediatric population and to create standardized management algorithms in the future. 相似文献999.
The purpose of this study was to compare dye leakage in the dentin of resected and nonresected roots. Fifty-four single rooted extracted teeth were used. The two groups were subdivided into young, middle age, and old age samples. Each sample was biomechanically prepared in a standard fashion and obturated using lateral condensation with sealer and gutta-percha. All root surfaces were sealed with nail polish, leaving the apical portion exposed. The apical portion of the roots were placed in 2% methylene blue dye for 72 h, rinsed, and placed in 15 ml of 35% HNO3 for 72 h. The supernatant was analyzed at 640 nm using a visible light spectrophotometer. The amount of leakage was extrapolated from a standard linear regression curve constructed from the stock 2% methylene blue dye solution. The percentage of concentration leakage in all samples ranged from less than 0.0600 to 0.1658. It was concluded that there is a greater amount of leakage in resected versus nonresected extracted teeth. The data also suggest that older teeth exhibit less leakage than younger teeth. 相似文献
1000.
Specificity of mannan antigen and anti‐mannan antibody screening in patients with haematological malignancies at risk for fungal infection 下载免费PDF全文
Wiebke Duettmann Christoph Koidl Robert Krause Gertrude Lackner Albert Woelfler Martin Hoenigl 《Mycoses》2016,59(6):374-378
Combination of mannan antigen and anti‐mannan antibody (Mn/A‐Mn) testing has been reported a useful and specific strategy for diagnosis of invasive Candida infections (ICIs). We evaluated Mn/A‐Mn as a screening tool in patients with haematological malignancies. This clinical prospective study was performed at the Division of Hematology, Medical University Graz, Austria between July and December 2012. Patients at risk for fungal infection were included into the study and twice weekly screened by Mn/A‐Mn testing, yielding 650 samples. Of overall 67 patients 66 had no evidence for ICI. From those, 153/640 serum samples (23.9%) were positive for mannan Ab, and nine (1.4%) for Ag. Most false positive Ab results were observed among 375 samples from patients without haematopoietic stem cell transplantation (34.9% resulted positive). Combined specificity of Mn/A‐Mn was 74.8%. Of 10 samples obtained in the single patient with candidemia, five were positive for mannan Ag (from the day of diagnosis up to 40 days after detection of candidemia) and none for Ab. In conclusion, mannan Ab screening yielded a high number of false positive results. While mannan Ag was found to be highly specific and may have potential for diagnostic driven testing, mannan Ab testing cannot be recommended based on our study results. 相似文献