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11.
Klaus-Peter Ratzmann Siegfried Knospe Peter Heinke Bernd Schulz 《Acta diabetologica》1979,16(1):67-75
Summary We have studied the interrelationship of total body fat mass, carbohydrate tolerance and IRI response in 17 non-obese and
obese subjects, who were suspected of having early diabetes. We carried out an i.v. glucose infusion test consisting of a
priming injection of 0.33 g/kg followed by constant glucose infusion of 12 mg/kg/min in all persons. Total body fat mass was
estimated by the tritium dilution method. There was a positive correlation of body fat mass, fasting glucose concentration
and blood glucose concentration at 150 min as well as a strong correlation between body fat mass and BG area 60–120 min as
parameters of carbohydrate tolerance in all subjects, i.e. the degree of carbohydrate intolerance was directly related to
the quantity of total body fat mass. A similar correlation was found when the non-obese and obese groups were analyzed separately.
In neither group did total body fat mass correlate with parameters of IRI response. In obese subjects with pathological carbohydrate
tolerance, however, a positive correlation of basal IRI concentration and total body fat mass was found. Furthermore, a close
relation between basal IRI level and parameters of carbohydrate tolerance could be demonstrated in obese subjects. The present
study failed to demonstrate any correlation of parameters of carbohydrate tolerance and glucose-induced IRI response in either
group. Thus, the significant relationship between body fat mass and degree of carbohydrate intolerance indicates that total
body fat mass plays an important role in the disturbance of blood glucose homeostasis in early diabetes with and without obesity.
Investigation performed within the medical research project ‘Diabetes mellitus and disturbances of lipid metabolism’, Ministry
of Health, GDR. 相似文献
12.
Mueller AR Platz KP Kremer B 《Best Practice & Research: Clinical Gastroenterology》2004,18(5):881-900
Liver transplantation is a highly successful treatment for patients with end-stage liver disease and acute liver failure. However, serious postoperative complications can significantly compromise patient survival. Complications can be technical, medical, or immunological in nature. The risk of developing early postoperative complications is associated with the patient's preoperative condition, the quality of the donor liver, the quality of the donor and recipient procedure, initial graft function, and perioperative anaesthesiological and intensive care management. The patient's preoperative condition can include gastrointestinal bleeding, acute renal failure, a requirement for cathecholamines or mechanical ventilation, and prolonged encephalopathy for the most detrimental risk factors for developing early postoperative complications. The necessity for prolonged mechanical ventilation or the requirement for reintubation after transplantation can significantly increase the risk of developing pneumonia, sepsis, and multiple organ dysfunction. A decrease in infectious and other complications can be achieved by early postoperative enteral nutition, including the application of probiotics. 相似文献
13.
Differential enhancement of collagen crosslink excretion in cases of osteosarcoma and chondrosarcoma
Açil Y Springer I Behrens P Ullrich KP Hedderich J Bruns J 《Journal of cancer research and clinical oncology》2003,129(10):583-588
Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are markers of collagen absorption and LP is specific for collagen type I in bone. In the present study we evaluated the concentration of HP and LP in urine of patients with osteosarcoma (n=20; age range 16–49 years) and chondrosarcoma (n=15; age range 18–70 years). The values were compared with those obtained from 74 healthy controls (age range 16–83 years). The range and upper limit of normal values (HPmax and LPmax) were measured in our control group. High performance liquid chromatography (HPLC) was used to determine concentrations of HP and LP (nmol/mmol creatinine). The average urinary HP concentrations were significantly increased in patients with osteosarcoma (p=0.001) and chondrosarcoma (p<0.001), whereas HP remained within the normal range in approximately half of the patients. The average urinary LP concentrations were not increased in osteosarcoma and chondrosarcoma patients as compared with the control group. Further studies in a large group of patients are necessary to evaluate whether HP might be a valuable marker of prognosis, and if its urinary concentration can be correlated to tumour burden. 相似文献
14.
Kensche A. Pötschke S. Hannig C. Dürasch A. Henle T. Hannig M. 《Clinical oral investigations》2020,24(11):3871-3880
Clinical Oral Investigations - The adsorption of bovine milk caseins on the tooth surface might have a positive impact on the prevention of dental diseases. Therefore, the present study aimed to... 相似文献
15.
Frank Leypoldt Mathias Gelderblom Daniel Schöttle Sascha Hoffmann Klaus-Peter Wandinger 《Journal of clinical neuroscience》2013,20(4):611-613
Encephalitis associated with antibodies against N-methyl-d-aspartic acid (NMDA) receptor is characterized by severe memory deficits, decreased consciousness, epileptic seizures and movement disorders and occurs most commonly in young women. Recovery is mostly good but little is known about the disease course in patients whose treatment has been delayed severely. We present a 16-year-old girl with a 36-month follow-up. A single course of methylprednisolone attenuated some symptoms but severe and incapacitating frontotemporal syndrome remained. Second-line treatment with rituximab was initiated 12 months after the onset of symptoms. A surprising recovery occurred 18 months after treatment and 30 months after onset. Recovery in NMDA receptor antibody-associated encephalitis can be severely delayed and does not have to be linear. Whether delayed therapy contributed to recovery in this patient cannot be answered with certainty. Spontaneous recovery independent of therapy is possible, as it has been observed previously as late as 3 years after onset. Although serum antibodies disappeared with recovery in this patient, previous cases have shown serum antibodies to be unreliable markers of disease activity. Second-line treatment, especially with substances as well tolerated as rituximab, should at least be considered in NMDA receptor encephalitis with persistent neuropsychiatric syndromes after first-line therapy. 相似文献
16.
Helmut Kirchmann Robert Mestel Karin Schreiber-Willnow Dankwart Mattke Klaus-Peter Seidler Elke Daudert 《Psychotherapy research》2013,23(2):234-248
Abstract Within a multisite study, including 289 inpatients from six different hospitals who underwent interpersonal-psychodynamic group psychotherapy, associations among attachment characteristics, therapeutic factors, and treatment outcome were investigated. Attachment characteristics were assessed with an interview-based measure (Adult Attachment Prototype Rating [AAPR]) as well as an attachment self-report (Bielefeld Questionnaire of Client Expectations [BQCE]). Therapeutic factors were measured retrospectively with the Düsseldorf Therapeutic Factors Questionnaire and treated as an individual- as well as a hospital-specific characteristic. On an individual level, only the group climate factor independently predicted treatment outcome (i.e., Symptom Checklist-90-R Global Severity Index and Inventory of Interpersonal Problems mean). If simultaneously but separately included into a path model, analyses revealed independent significant effects of AAPR-Security and BQCE-Security on group climate. If modeled as a latent variable (common attachment security), a substantially higher proportion of group climate variance could be explained. Further analyses revealed interactions between particular therapeutic factors and attachment characteristics, indicating a particular importance of these therapeutic factors for different attachment categories. 相似文献
17.
Yi Su Wendelin Bhm Marco Wenzel Silvia Paasch Margret Acker Thomas Doert Eike Brunner Thomas Henle Jan J. Weigand 《RSC advances》2020,10(73):45116
The increasing concerns on uranium and rare earth metal ion pollution in the environment require sustainable strategies to remove them from wastewater. The present study reports an eco-friendly approach to convert a kind of protein-rich biomass, brewer''s spent grain (BSG), into effective biosorbents for uranyl and rare earth metal ions. The employed method reduces the energy consumption by performing the hydrothermal treatment at a significantly lower temperature (150 °C) than conventional hydrothermal carbonization. In addition, with the aid of the Maillard reaction between carbohydrates and proteins forming melanoidins, further activation processes are not required. Treatment at 150 °C for 16 h results in an altered biosorbent (ABSG) with increased content of carboxyl groups (1.46 mmol g−1) and a maximum adsorption capacity for La3+, Eu3+, Yb3+ (pH = 5.7) and UO22+ (pH = 4.7) of 38, 68, 46 and 221 mg g−1, respectively. Various characterization methods such as FT-IR, 13C CP/MAS NMR, SEM-EDX and STA-GC-MS analysis were performed to characterize the obtained material and to disclose the adsorption mechanisms. Aside from oxygen-containing functional groups, nitrogen-containing functional groups also contribute to the adsorption. These results strongly indicate that mild hydrothermal treatment of BSG could be applied as a greener, low-cost method to produce effective adsorbents for uranyl and rare earth metal ion removal.Effective biosorbent ABSG is obtained via hydrothermal treatment of BSG at low temperature without activation, minimizing energy consumption and environmental impact. 相似文献
18.
Biophotonics in the infrared spectral range reveal acupuncture meridian structure of the body 总被引:4,自引:0,他引:4
Schlebusch KP Maric-Oehler W Popp FA 《Journal of alternative and complementary medicine (New York, N.Y.)》2005,11(1):171-173
This study shows, for the first time, evidence of the existence of the acupuncture meridian structure in the human body. After moxibustion (or similar light stimulation) of the body in the 3-5 microm range, "light channels" appear on the body, which appear to be identical to what are known as meridians in all textbooks of Traditional Chinese Medicine. These findings appear not only to confirm the existence of acupuncture meridians, but they also open a new window on understanding the energy transfer dynamics of the human body. Furthermore, it is likely that living matter is not in the ground state, but permanently electronically excited. 相似文献
19.
20.
Annette Conzelmann Antje B. M. Gerdes Ronald F. Mucha Peter Weyers Klaus-Peter Lesch Christina G. Bähne 《The world journal of biological psychiatry》2014,15(1):56-65
Objectives. This study investigates an overall autonomic hypoactivity reflecting hypoarousal as important aetiological factor in ADHD at baseline during rest and in response towards stimuli. In addition, effects of methylphenidate (MPH) are examined. We further assessed whether this hypoarousal is a stable characteristic or ameliorated by arousing emotional stimuli. Methods. Boys with ADHD were examined with (n = 35) or without MPH (n = 45) and compared with healthy boys (n = 22) regarding skin conductance level (SCL) during rest and skin conductance responses (SCRs) as well as valence and arousal ratings in response to positive, neutral, and negative pictures. Results. ADHD children without MPH were characterized by reduced baseline SCL and overall reduced SCRs. ADHD children with MPH never differed from control children. All groups displayed normal valence and arousal ratings of the stimuli and enhanced SCRs to emotional in comparison to neutral pictures. Conclusions. This is the first study to unravel (1) a general autonomic hypoactivity in ADHD children at baseline and in response to low arousing neutral and highly arousing emotional stimuli, and (2) hints that MPH normalizes this hypoactivity. Results contribute to the understanding of ADHD aetiology and MPH functionality, and are consistent with the cognitive-energetic model of ADHD. 相似文献