全文获取类型
收费全文 | 4184篇 |
免费 | 244篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 55篇 |
儿科学 | 144篇 |
妇产科学 | 136篇 |
基础医学 | 466篇 |
口腔科学 | 94篇 |
临床医学 | 309篇 |
内科学 | 793篇 |
皮肤病学 | 107篇 |
神经病学 | 265篇 |
特种医学 | 259篇 |
外国民族医学 | 1篇 |
外科学 | 668篇 |
综合类 | 201篇 |
预防医学 | 243篇 |
眼科学 | 106篇 |
药学 | 383篇 |
中国医学 | 34篇 |
肿瘤学 | 194篇 |
出版年
2023年 | 27篇 |
2022年 | 85篇 |
2021年 | 123篇 |
2020年 | 59篇 |
2019年 | 96篇 |
2018年 | 123篇 |
2017年 | 94篇 |
2016年 | 91篇 |
2015年 | 99篇 |
2014年 | 153篇 |
2013年 | 173篇 |
2012年 | 229篇 |
2011年 | 260篇 |
2010年 | 174篇 |
2009年 | 147篇 |
2008年 | 204篇 |
2007年 | 211篇 |
2006年 | 179篇 |
2005年 | 184篇 |
2004年 | 145篇 |
2003年 | 138篇 |
2002年 | 103篇 |
2001年 | 57篇 |
2000年 | 67篇 |
1999年 | 83篇 |
1998年 | 84篇 |
1997年 | 83篇 |
1996年 | 79篇 |
1995年 | 59篇 |
1994年 | 59篇 |
1993年 | 47篇 |
1992年 | 48篇 |
1991年 | 54篇 |
1990年 | 63篇 |
1989年 | 50篇 |
1988年 | 50篇 |
1987年 | 41篇 |
1986年 | 46篇 |
1985年 | 35篇 |
1984年 | 18篇 |
1983年 | 19篇 |
1982年 | 25篇 |
1981年 | 18篇 |
1980年 | 21篇 |
1979年 | 29篇 |
1978年 | 18篇 |
1976年 | 31篇 |
1974年 | 24篇 |
1973年 | 19篇 |
1971年 | 16篇 |
排序方式: 共有4458条查询结果,搜索用时 15 毫秒
11.
Joseph Cofrancesco Nina Shah Khalil G Ghanem Adrian S Dobs Robert S Klein Kenneth Mayer Paula Schuman David Vlahov Anne M Rompalo 《Gynecological endocrinology》2006,22(5):244-251
Drug use and HIV infection may affect sex hormone levels in women. One hundred and ninety-six women with and without a history of illicit drug use (50 HIV-negative and 148 HIV-infected), with regular menses, who never used antiretrovirals, were evaluated. Luteinizing hormone levels were significantly higher in women with a CD4 cell count <200/microl (p < 0.002). Current methadone use was associated with lower levels of total testosterone (p = 0.03) and higher levels of prolactin (p = 0.002); mean estradiol levels were 43% lower in women who used intravenous drugs (p < 0.001). Alcohol and crack cocaine use was not associated with sex hormone levels. Age, race, body mass index and degree of HIV immunosuppression were also associated with differences in sex hormone levels. 相似文献
12.
Nadia Sdiqui Khalil Arar Patrick Midoux Roger Mayer Michel Monsigny Annie-Claude Roche 《Drug delivery》1995,2(1):63-72
The Ha-ras oncogene promotes cell proliferation. Antisense oligonucleotides complementary to the ras gene sequence encompassing a mutated codon 12 selectively induce a cell proliferation inhibition. However, the concentration required to reach an effective inhibition is high due to the low efficiency of the oligonucleotide crossing through cell membranes, leading to a low concentration in the cytosol and/or the nucleoplasm. In the present paper, we show that anti-ras oligonucleotides linked to a glycosylated carrier, serum albumin bearing mannose 6-phosphate residues, are more efficient than free oligonucleotides or oligonucleotides bound to an unglycosylated carrier at inhibiting proliferation of a human tumor mammary cell line expressing the mutated Ha-ras. Using fluorescein-labeled neoglycoproteins and fluorescein-labeled oligonucleotides bound to neoglycoproteins, flow cytometry and confocal microscopy revealed that (i) these tumor cells express a membrane lectin specific for mannose 6-phosphate-bearing proteins, (ii) the membrane lectin actively mediates the uptake of macromolecules substituted with mannose 6-phosphate, and (iii) the fluorescein-labeled oligonucleotides bound to the neoglycoprotein accumulate in intracellular vesicles. Furthermore, with antisense oligonucleotides carried by the neoglycoproteins, the concentration required to inhibit cell proliferation is lower than that of the carrier-free antisense oligonucleotides. 相似文献
13.
14.
15.
16.
17.
18.
Dr. M. Khalil M.D. Dr. A. R. Iwatt E.M.C.S. Prof. H. C. Gugnani Ph.D. 《Diseases of the colon and rectum》1989,32(6):518-520
A case of African histoplasmosis primarily affecting the large bowel—a very unusual manifestation—is reported. In the absence
of classical clinical features, pathognomonic of large bowel histoplasmosis, the macroscopic appearance at surgery was confused
with large-bowel cancer. The diagnosis was, therefore, retrospective and based on demonstration of large yeast cells ofHistoplasma capsulatum var.duboisii in tissue sections of the lesions. 相似文献
19.
20.
In most Special Care Neonatal Units (SCNUs) in India, mothers are excluded from the care of their sick babies for fear of over-crowding and dislocation. We have attempted to study the feasibility of involving mothers in the care of their babies admitted for neonatal septicemia and to analyse whether this changed the sepsis related case fatality rate. The study material consisted of 158 neonates with blood culture positive neonatal septicemia whose mothers were actively involved in their care during their stay in the SCNU of LNJPN Hospital throughout 1987-88. The mothers lived in with their sick neonates and were extremely useful in feeding, cleaning, and monitoring for some important signs and symptoms. There were no epidemics of infection in the nursery during this period. All the babies discharged were receiving breast feeds, and the mothers were confident in taking care of them before discharge. The mortality in this group was 43%. The onset of septicemia was most often in the first week (36%) being 25.9% in second week, 26.6% in the third, and 11.4% in the fourth. Mortality was maximum (64.5%) when the onset of illness was in the first 3 days. Klebsiella and S. aureus were commonly isolated organisms (38.6 and 21.5%, respectively). Gram negative organisms were isolated in 66.5% cases with higher mortality in this group. Nearly 46% of the babies weighed 2 kg or less, with a mortality of 60.2% compared to 28.2% in those more than 2 kg. Only 3 to 5% and 40 to 66.7% of Gram negative and 23 and 70% of Gram positive organisms were sensitive to ampicillin and gentamicin, respectively. 相似文献