全文获取类型
收费全文 | 4138篇 |
免费 | 395篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 118篇 |
妇产科学 | 73篇 |
基础医学 | 416篇 |
口腔科学 | 75篇 |
临床医学 | 504篇 |
内科学 | 880篇 |
皮肤病学 | 73篇 |
神经病学 | 427篇 |
特种医学 | 222篇 |
外科学 | 423篇 |
综合类 | 111篇 |
一般理论 | 2篇 |
预防医学 | 454篇 |
眼科学 | 105篇 |
药学 | 258篇 |
中国医学 | 1篇 |
肿瘤学 | 402篇 |
出版年
2021年 | 48篇 |
2020年 | 33篇 |
2019年 | 49篇 |
2018年 | 79篇 |
2017年 | 59篇 |
2016年 | 72篇 |
2015年 | 60篇 |
2014年 | 89篇 |
2013年 | 152篇 |
2012年 | 201篇 |
2011年 | 193篇 |
2010年 | 122篇 |
2009年 | 100篇 |
2008年 | 174篇 |
2007年 | 177篇 |
2006年 | 203篇 |
2005年 | 181篇 |
2004年 | 178篇 |
2003年 | 177篇 |
2002年 | 169篇 |
2001年 | 122篇 |
2000年 | 126篇 |
1999年 | 98篇 |
1998年 | 67篇 |
1997年 | 59篇 |
1996年 | 68篇 |
1995年 | 50篇 |
1994年 | 63篇 |
1993年 | 39篇 |
1992年 | 92篇 |
1991年 | 86篇 |
1990年 | 99篇 |
1989年 | 74篇 |
1988年 | 108篇 |
1987年 | 68篇 |
1986年 | 77篇 |
1985年 | 65篇 |
1984年 | 56篇 |
1983年 | 58篇 |
1982年 | 30篇 |
1981年 | 37篇 |
1979年 | 38篇 |
1978年 | 34篇 |
1977年 | 34篇 |
1976年 | 40篇 |
1975年 | 38篇 |
1974年 | 49篇 |
1973年 | 43篇 |
1972年 | 29篇 |
1969年 | 25篇 |
排序方式: 共有4559条查询结果,搜索用时 562 毫秒
91.
SB Cho JH Kim S Cho JM Park YK Park SH Oh 《Journal of the European Academy of Dermatology and Venereology》2011,25(1):64-67
Background The clinical characteristics of vitiligo in children and adolescents with an emphasis on thyroid dysfunction have only been reported in a few studies. Objective The purpose of this study was to examine the characteristics of children and adolescents with vitiligo and compare the incidence of thyroid dysfunction between them and controls without vitiligo at the same age. Methods A retrospective analysis of 324 Korean children and adolescents with vitiligo was performed. The results of thyroid function screening tests in them (n = 254) were compared with controls (n = 122). Results Of the total 324 children and adolescents with vitiligo, vitiligo vulgaris was the most common type (42.3%) and the most commonly involved site was the face (54.6%). A total of 15 of 254 (5.9%) patients screened for thyroid function were diagnosed with thyroid disease (four had Hashimoto’s thyroiditis; two, Graves’ disease; seven, subclinical hypothyroidism; and two, subclinical hyperthyroidism). None of the 50 patients with segmental vitiligo showed any thyroid dysfunction (P = 0.047). There was no significant difference in the incidence of thyroid disease between children and adolescents with vitiligo and the control group, in which seven of 122 (5.7%) showed thyroid dysfunction. Conclusion In this study, we demonstrated the characteristics of children and adolescents with vitiligo and also observed no significant difference in the incidence of thyroid disease between children and adolescents with vitiligo and the control group. 相似文献
92.
93.
94.
David J. Guervil Keith S. Kaye Ali Hassoun Phillip Cole Xing-Yue Huang H. David Friedland 《Journal of chemotherapy (Florence, Italy)》2016,28(3):180-186
The Clinical Assessment Program and Teflaro® Utilization Registry (CAPTURE) is a multicenter registry study of acute bacterial skin and skin structure infection (ABSSSI) and community-acquired bacterial pneumonia (CABP) patients treated with ceftaroline fosamil in the US. Data for this analysis were collected between August 2011 and February 2013 at US study centres by randomly ordered chart review. Clinical success rates among ABSSSI patients were >81% when ceftaroline fosamil was used as first- or second-line therapy, including monotherapy and concurrent therapy. Among CABP patients, clinical success rates were >77% among first-line and second-line patients and patients who received first-line concurrent therapy or second line monotherapy or concurrent therapy. For CABP patients treated with ceftaroline fosamil as first-line monotherapy, the clinical success rate was 70%. Ceftaroline fosamil is an effective treatment option for patients with ABSSSI or CABP with similar clinical success rates when used as first-line or second-line treatment. 相似文献
95.
Alan D. Kaye McKenzie Mayo Hollon Nalini Vadivelu Gopal Kodumudi Rachel J. Kaye Franklin Rivera Bueno Amir R. Baluch 《Journal of anesthesia》2013,27(3):423-432
Recovery from anesthesia is ideally routine and uneventful. After extubation, the recovering postoperative patient ought to breathe without supportive care or additional oxygenation. It has been demonstrated in previous studies that postoperative pulmonary complications are clinically relevant in terms of mortality, morbidity, and length of hospital stay. Compromised postoperative ventilation can be described as the condition in which the postoperative patient does not have satisfactory spontaneous ventilation support and adequate oxygenation. Causes of impaired ventilation, oxygenation, and airway maintenance can be mechanical, hemodynamic, and pharmacologic. This review describes prevalence and differential diagnosis, including co-morbidities of postoperative apnea. The physiological mechanisms of breathing and prolonged postoperative apnea are also reviewed; these mechanisms include influences from the brainstem, the cerebral cortex, and chemoreceptors in the carotid and aortic body. Causes of prolonged postoperative apnea and management are also discussed. 相似文献
97.
Leslie K. Anderson Erin E. Reilly Laura Berner Christina E. Wierenga Michelle D. Jones Tiffany A. Brown Walter H. Kaye Anne Cusack 《Current psychiatry reports》2017,19(8):48
Higher levels of care (HLC)—including inpatient hospitalization, residential treatment, partial hospitalization, and intensive outpatient treatment—are frequently utilized within routine care for eating disorders. Despite widespread use, there is limited research evaluating the efficacy of HLC, as well as clinical issues related to care in these settings. This review describes the different levels of care for eating disorders and briefly reviews the most up-to-date guidelines and research regarding how to choose a level of care. In addition, as HLC approaches for ED continue to be developed and refined, pragmatic and conceptual challenges have emerged that provide barriers to clinical efficacy and the execution of high-quality treatment research. This review includes a discussion of various issues specific to HLC, as well as a summary of recent literature addressing them. 相似文献
98.
99.
Mohamed I. Husseiny Jeffrey Rawson Alexander Kaye Indu Nair Ivan Todorov Michael Hensel Fouad Kandeel Kevin Ferreri 《Vaccine》2014
Type 1 diabetes (T1D) is a metabolic disease that is initiated by the autoimmune destruction of pancreatic insulin-producing beta cells that is accompanied by the development of antigen-specific antibodies and cytotoxic T lymphocytes (CTLs). Several studies have shown that vaccination with diabetic autoantigens provides some protection against this process. In this report we describe a new oral vaccine that utilizes live attenuated Salmonella for simultaneous delivery of autoantigens in conjunction with immunomodulatory cytokine genes to immune cells in the gut mucosa. Recent data showed that live attenuated Salmonella is a safe, simple and effective vector for expression of antigens and cytokines by antigen-presenting cells (APCs) of gut-associated lymphatic tissue (GALT). This novel strategy was tested by fusion of the diabetic autoantigen preproinsulin with Salmonella secretory effector protein (SseF) of pathogenicity island-2 (SPI2). In this way the autoantigen is only expressed inside the host immune cells and translocated to the host cell cytosol. In addition Salmonella was used to deliver the gene for the immunomodulatory cytokine transforming growth factor beta (TGFβ) for host cell expression. Oral co-vaccination of 8 week-old non-obese diabetic (NOD) mice with three weekly doses of both the autoantigen and cytokine significantly reduced the development of diabetes, improved the response to glucose challenge, preserved beta cell mass, and reduced the severity of insulitis compared with controls and autoantigen alone. Combination therapy also resulted in increased circulating levels of IL10 four weeks post-vaccination and IL2 for 12 weeks post-vaccination, but without effect on proinflammatory cytokines IL6, IL12(p70), IL17 and IFNγ. However, in non-responders there was a significant rise in IL12 compared with responders. Future studies will examine the mechanism of this vaccination strategy in more detail. In conclusion, Salmonella-based oral vaccines expressing autoantigens combined with imunomodulatory cytokines appears to be a promising therapy for prevention of T1D. 相似文献
100.