全文获取类型
收费全文 | 4138篇 |
免费 | 395篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 118篇 |
妇产科学 | 73篇 |
基础医学 | 416篇 |
口腔科学 | 75篇 |
临床医学 | 504篇 |
内科学 | 880篇 |
皮肤病学 | 73篇 |
神经病学 | 427篇 |
特种医学 | 222篇 |
外科学 | 423篇 |
综合类 | 111篇 |
一般理论 | 2篇 |
预防医学 | 454篇 |
眼科学 | 105篇 |
药学 | 258篇 |
中国医学 | 1篇 |
肿瘤学 | 402篇 |
出版年
2021年 | 48篇 |
2020年 | 33篇 |
2019年 | 49篇 |
2018年 | 79篇 |
2017年 | 59篇 |
2016年 | 72篇 |
2015年 | 60篇 |
2014年 | 89篇 |
2013年 | 152篇 |
2012年 | 201篇 |
2011年 | 193篇 |
2010年 | 122篇 |
2009年 | 100篇 |
2008年 | 174篇 |
2007年 | 177篇 |
2006年 | 203篇 |
2005年 | 181篇 |
2004年 | 178篇 |
2003年 | 177篇 |
2002年 | 169篇 |
2001年 | 122篇 |
2000年 | 126篇 |
1999年 | 98篇 |
1998年 | 67篇 |
1997年 | 59篇 |
1996年 | 68篇 |
1995年 | 50篇 |
1994年 | 63篇 |
1993年 | 39篇 |
1992年 | 92篇 |
1991年 | 86篇 |
1990年 | 99篇 |
1989年 | 74篇 |
1988年 | 108篇 |
1987年 | 68篇 |
1986年 | 77篇 |
1985年 | 65篇 |
1984年 | 56篇 |
1983年 | 58篇 |
1982年 | 30篇 |
1981年 | 37篇 |
1979年 | 38篇 |
1978年 | 34篇 |
1977年 | 34篇 |
1976年 | 40篇 |
1975年 | 38篇 |
1974年 | 49篇 |
1973年 | 43篇 |
1972年 | 29篇 |
1969年 | 25篇 |
排序方式: 共有4559条查询结果,搜索用时 15 毫秒
31.
32.
D. J. Kerr G. J. Rustin S. B. Kaye P. Selby N. M. Bleehen P. Harper M. H. Brampton 《British journal of cancer》1995,72(5):1267-1269
Rhizoxin is a tubulin-binding anti-neoplastic agent which is active in a range of murine tumour models. The recommended schedule, of intravenous (i.v.) bolus administration at a dose of 2 mg m-2 every 3 weeks, has been assessed in three phase II trials of ovarian, renal and colorectal cancer. In general terms the drug was fairly well tolerated, but the response rate was disappointing: 0/18, colorectal cancer; 0/18, renal cancer; 1 partial response (PR)/17, ovarian cancer. 相似文献
33.
A total of 141 patients admitted to hospital with a diagnosis of suspected myocardial infarction were randomized to treatment with intravenous diamorphine (71) or nalbuphine (70). Myocardial infarction was subsequently confirmed in 109 patients. Both drugs provided good analgesia. Heart rate, blood pressure, respiratory rate, peak flow and minute volume were measured over a three-hour study period. Except for a slight fall in systolic blood pressure in the nalbuphine-treated group, there were no statistically significant differences between the groups. The nalbuphine-treated group had higher levels of aspartate aminotransferase and hydroxybutyric acid dehydrogenase but not creatine phosphokinase. The haemodynamic outcome and mortality at three months of the two groups were similar. It is concluded that nalbuphine provides effective analgesia coupled with few adverse circulatory or respiratory effects. 相似文献
34.
D Cunningham M Soukop N L Gilchrist G J Forrest D C Carter C S McArdle S B Kaye J W Dobbie M Smith 《Medical oncology and tumor pharmacotherapy》1986,3(1):25-28
Twenty-five patients, 16 with gastric cancer and nine with colonic cancer, received TNO-6 30 mg m-2 every four weeks. No objective tumour response was recorded. Nausea and vomiting occurred in 21 patients and was severe in 17. Severe marrow suppression developed in five patients. Renal function was unaffected in all but one patient who developed renal failure, probably as a result of septicaemia. However, the renal tubular enzyme N-acetyl-beta-D-glucosaminidase was measured in six patients and showed a rise in all. In this study TNO-6 had no anti-tumour activity in gastrointestinal malignancy, but produced significant renal tubular damage. 相似文献
35.
36.
进一步研究了抗三尖杉酯碱的HL-60细胞(HR20)抗细胞凋亡的机制及该抗性和抗药性的关系。结果表明,环孢菌素A(CsA)20,10μg·ml ̄(-1)诱导HL-60细胞发生凋亡,而阻断HR20细胞于G_1期,就不能诱导细胞发生凋亡。低浓度的CsA明显增加柔红霉素在HR20细胞内的积聚,其逆转抗药性作用与阻断细胞周期运行无关。CsA10μg·ml ̄(-1)处理HR20细胞,可引起50kDa的蛋白质高度磷酸化。结果提示:环孢菌素A阻断抗三尖杉酯碱的HL-60细胞于G_1期,而诱导敏感的HL-60细胞发生凋亡,其阻断作用与抗药性无关 相似文献
37.
38.
Cody JD Semrud-Clikeman M Hardies LJ Lancaster J Ghidoni PD Schaub RL Thompson NM Wells L Cornell JE Love TM Fox PT Leach RJ Kaye CI Hale DE 《American journal of medical genetics. Part A》2005,137(1):9-15
Most individuals with constitutional deletions of chromosome 18q have developmental delays, dysmyelination of the brain, and growth failure due to growth hormone deficiency. We monitored the effects of growth hormone treatment by evaluating 23 individuals for changes in growth, nonverbal intelligence quotient (nIQ), and quantitative brain MRI changes. Over an average of 37 months, the treated group of 13 children had an average nIQ increase of 17 points, an increase in height standard deviation score of 1.7, and significant change in T1 relaxation times in the caudate and frontal white matter. Cognitive changes of this magnitude are clinically significant and are anticipated to have an effect on the long-term outcomes for the treated individuals. 相似文献
39.
Kaye SB Lloyd M Williams H Yuen C Scott JA O'Donnell N Batterbury M Hiscott P Hart CA 《Journal of medical virology》2005,77(2):227-231
Chronic papillary conjunctivitis has been described following adenoviral conjunctivitis. It is unknown however, how long adenovirus is able to persist in the tear film and conjunctiva. To determine if adenovirus persists in the ocular surface following adenoviral conjunctivitis, 304 patients with a history of adenovirus conjunctivitis from whom an adenovirus had been isolated 10 years previously were sent a questionnaire regarding persistent or recurrent symptoms and were invited to attend. Patients were examined and samples of tears and conjunctival cells were collected from both eyes using tear film washes, filter paper, and swabs, the latter for virus isolation. Extracted DNA from the ocular samples was amplified using primers for herpes simplex virus (thymidine kinase) and adenovirus (hexon) genes. Adenovirus amplicons were sequenced and compared to original serotype. Thirty patients attended, 19 of whom had persistent papillary conjunctivitis. Evidence of adenovirus DNA was detected in 17 of 30 patients, 15 of whom also had evidence of a chronic papillary conjunctivitis. Adenovirus DNA was significantly associated with papillary conjunctivitis (P = 0.03). Adenovirus amplicons were successfully sequenced from six patients. Four patients harbored type 3 adenovirus, the same serotype with which they were infected originally 10 years previously. Two patients were infected originally with adenovirus serotype 3 but the current serotype was type 4. Infection of the ocular surface with adenovirus may predispose to the development of a persistent or recurrent conjunctivitis, the presence of which, appears to be associated with evidence of long term persistence of adenovirus DNA. 相似文献
40.
Celia I. Kaye Alice O. Martin Beverly R. Rollnick R. Rollnick Konrad Nagatoshi Jeannette Israel Mark Hermanoff Brad Tropea Joan T. Richtsmeier Newton E. Morton 《American journal of medical genetics. Part A》1992,43(6):913-917
Seventy-four families of probands with oculoauriculovertebral anomaly were evaluated, including 116 parents and 195 off-spring. Relatives were examined to identify ear malformations, mandibular anomalies, and other craniofacial abnormalities. For segregation analysis using POINTER, selection of the sample was consistent with single as-certainment. Different population liabilities were used for probands and relatives, because affection was narrowly defined for probands and broadly defined for relatives. The hypothesis of no genetic transmission was rejected. The evidence favored autosomal dominant inheritance; recessive and polygenic models were not distinguishable. © 1992 Wiley-Liss, Inc. 相似文献