全文获取类型
收费全文 | 9035篇 |
免费 | 967篇 |
国内免费 | 61篇 |
专业分类
耳鼻咽喉 | 65篇 |
儿科学 | 207篇 |
妇产科学 | 241篇 |
基础医学 | 1584篇 |
口腔科学 | 186篇 |
临床医学 | 1219篇 |
内科学 | 1885篇 |
皮肤病学 | 81篇 |
神经病学 | 772篇 |
特种医学 | 282篇 |
外国民族医学 | 1篇 |
外科学 | 1165篇 |
综合类 | 155篇 |
一般理论 | 7篇 |
预防医学 | 941篇 |
眼科学 | 123篇 |
药学 | 445篇 |
中国医学 | 11篇 |
肿瘤学 | 693篇 |
出版年
2022年 | 66篇 |
2021年 | 149篇 |
2020年 | 91篇 |
2019年 | 144篇 |
2018年 | 154篇 |
2017年 | 137篇 |
2016年 | 158篇 |
2015年 | 179篇 |
2014年 | 236篇 |
2013年 | 366篇 |
2012年 | 492篇 |
2011年 | 505篇 |
2010年 | 329篇 |
2009年 | 288篇 |
2008年 | 476篇 |
2007年 | 514篇 |
2006年 | 497篇 |
2005年 | 428篇 |
2004年 | 437篇 |
2003年 | 459篇 |
2002年 | 405篇 |
2001年 | 186篇 |
2000年 | 186篇 |
1999年 | 174篇 |
1998年 | 136篇 |
1997年 | 124篇 |
1996年 | 121篇 |
1995年 | 81篇 |
1994年 | 82篇 |
1993年 | 76篇 |
1992年 | 143篇 |
1991年 | 152篇 |
1990年 | 153篇 |
1989年 | 132篇 |
1988年 | 149篇 |
1987年 | 117篇 |
1986年 | 152篇 |
1985年 | 128篇 |
1984年 | 93篇 |
1983年 | 100篇 |
1982年 | 62篇 |
1981年 | 69篇 |
1979年 | 79篇 |
1978年 | 59篇 |
1977年 | 60篇 |
1976年 | 65篇 |
1975年 | 53篇 |
1974年 | 61篇 |
1973年 | 69篇 |
1970年 | 55篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
Leah L. Albers Deborah Anderson Leslie Cragin Susan Moore Daniels Christine Hunter Kay D. Sedler Dusty Teaf 《Journal of Midwifery & Women's Health》1996,41(4):269-276
We conducted an observational cohort study in three nurse-midwifery services to identify patient characteristics and clinical care measures related to perineal trauma at birth. Data were collected on all women who began care with a nurse-midwife in labor, using an adaptation of the Nurse-Midwifery Clinical Data Set (n = 3,049). Study variables included demographics, perineal management techniques and position for birth, and other intrapartum care and events. Univariate and multivariate analyses showed that episiotomy was strongly related to fetal bradycardia, prolonged second stage, ethnic status, and maternal education level. Warm compresses and flexion/counterpressure to slow delivery were protective. Spontaneous lacerations were influenced by these factors as well. The lateral position for birth was protective, and use of oils or lubricants and the lithotomy position increased lacerations. Multisite studies in nurse-midwifery practices may provide an ideal means of determining effective care measures in healthy populations. 相似文献
22.
23.
Ductal adenoma of the breast 总被引:1,自引:0,他引:1
Ductal adenoma is a recently described benign tumour of the breast that can be mistaken for carcinoma in both frozen and paraffin sections. Such a case is presented. Fortunately a mastectomy was not performed, but the patient did undergo axillary node dissection. Surgeons and pathologists should familiarize themselves with this lesion so that patients do not have to undergo unnecessary mastectomies and axillary node dissections. 相似文献
24.
C. R. Goucke MB ChB FFARACS J. P. Keaveny MB BCh BAO FFARCS B Kay DMSc MB ChB FFARCS T. E. J. Healy MSc MD FFARCS M. Ryan MB ChB FFARCS 《Anaesthesia》1990,45(4):329-331
Eighty-two outpatients who received general anaesthesia for surgical removal of maxillary or mandibular third molars were given either diclofenac 75 mg or nefopam 20 mg intramuscularly for postoperative pain control. They and the control group were also allowed oral paracetamol as required. The results showed that there was no significant pain relief from these single intramuscular injections. 相似文献
25.
Cyclophosphamide and etoposide therapy with GM-CSF for VAD-resistant multiple myeloma 总被引:1,自引:0,他引:1
Meletios A. Dimopoulos Kay B. Delasalle Richard Champlin Raymond Alexanian 《British journal of haematology》1993,83(2):240-244
Few effective regimens are available for patients with advanced multiple myeloma resistant to or relapsing after both alkylating agents and VAD. We treated 52 patients with advanced and refractory multiple myeloma with the combination of cyclophosphamide (3.0 g/m2 ) and etoposide (900 mg/m2 ) followed by GM-CSF at a daily dose of 0.125 mg/m2 until recovery of granulocytes. 42% of patients responded with a median time of 19 d for recovery of granulocytes to 0.5 x 109 /1 and a 4% mortality rate. Eight responding patients received a second myeloablative treatment supported by either autologous bone marrow (six patients) or blood stem cells (two patients). The median survival time for all patients was 11 months and the median remission time for responding patients was 8 months. The combination of cyclophosphamide and etoposide provided an effective rescue treatment for many patients with advanced multiple myeloma resistant to conventional therapies. This programme also allowed early marrow or blood stem cell collection in support of subsequent myeloablative therapy for selected patients. 相似文献
26.
27.
28.
A B Kay 《The American review of respiratory disease》1987,135(5):1200-1203
There is now very substantial evidence to implicate mediators in the pathogenesis of asthma during both the early- and late-phase response. It seems likely that mast cells are activated since histamine was detected in early- and late-phase allergen- and exercise-induced asthma. On the other hand, the origin of NCA is still in some doubt, and the possibility exists that it may be derived from other cell types. Furthermore, there is no firm evidence that the mast cell is directly involved in pathogenesis and some evidence that it may have a secondary or amplifying role. There is an urgent need for further details of other mast-cell-associated mediators such as prostaglandins and leukotrienes. Measurements in the blood have the obvious disadvantage of only indirectly reflecting events in the lung. It seems likely that more invasive procedures such as fiberoptic bronchoscopy will yield more critical information regarding mast cells and their mediators in early- and late-phase reactions, as well as the effects of selective drugs and the role of other cell types. 相似文献
29.
M. L. Margallo-Lana P. B. Moore D. W. K. Kay R. H. Perry B. E. Reid T. P. Berney & S. P. Tyrer 《Journal of intellectual disability research : JIDR》2007,51(6):463-477
Background The clinical and neuropathological features associated with dementia in Down’s syndrome (DS) are not well established. Aims To examine clinico‐pathological correlations and the incidence of cognitive decline in a cohort of adults with DS. Method A total of 92 hospitalized persons with DS were followed up from 1985 to December 2000. At outset, 87 participants were dementia‐free, with a median age of 38 years. Assessments included the Prudhoe Cognitive Function Test (PCFT) and the Adaptive Behavior Scale (ABS), to measure cognitive and behavioural deterioration. Dementia was diagnosed from case records and caregivers’ reports. Results Eighteen (21%) patients developed dementia during follow‐up, with a median age of onset 55.5 years (range 45–74). The PCFT demonstrated cognitive decline among those with a less severe intellectual disability (mild and moderate) but not among the profoundly disabled people (severe and profound). Clinical dementia was associated with neuropathological features of Alzheimer’s disease, and correlated with neocortical neurofibrillary tangle densities. At the age of 60 years and above, a little more than 50% of patients still alive had clinical evidence of dementia. Conclusions Clinical dementia associated with measurable cognitive and functional decline is frequent in people with DS after middle age, and can be readily diagnosed among less severely intellectually disabled persons using measures of cognitive function such as the PCFT and behavioural scales such as the ABS. In the more profoundly disabled people, the diagnosis of dementia is facilitated by the use of behavioural and neurological criteria. In this study, the largest prospective DS series including neuropathology on deceased patients, the density of neurofibrillary tangles related more closely to the dementia of DS than senile plaques. In people with DS surviving to middle and old age, the development of dementia of Alzheimer type is frequent but not inevitable, and some people with DS reach old age without clinical features of dementia. 相似文献
30.
Serum interleukin 5 concentrations in atopic and non-atopic patients with glucocorticoid-dependent chronic severe asthma. 总被引:7,自引:1,他引:6
下载免费PDF全文
![点击此处可从《Thorax》网站下载免费的PDF全文](/ch/ext_images/free.gif)
BACKGROUND--Interleukin (IL)-5 is thought to play a part in asthmatic bronchial mucosal inflammation and is a potential therapeutic target. Detectable serum IL-5 concentrations have been found previously in a proportion of patients with acute severe asthma, but not in the same patients following oral glucocorticoid therapy or in normal controls. A study was undertaken to investigate whether or not IL-5 is detectable in the serum of patients with glucocorticoid-dependent chronic severe asthma. METHODS--Serum concentrations of IL-5 were measured in 29 patients with stable oral glucocorticoid-dependent chronic severe asthma (mean PEFR 59.7% predicted) and seven normal controls using a specific enzyme-linked immunoassay calibrated with recombinant human IL-5 standards (lower limit of sensitivity 40 pg/ml). RESULTS--Interleukin 5 was detectable in the serum of 15 of the 29 patients at a median concentration of 150 pg/ml (range 40-690), but was undetectable in the serum of all the control subjects. The patients with detectable serum IL-5 concentrations did not differ from those with undetectable concentrations in terms of atopic status, disease severity (percentage predicted PEFR or FEV1), prednisolone dosage, serum IgE concentrations, or peripheral eosinophil count. CONCLUSIONS--Interleukin 5 is detectable in the serum of a proportion of both atopic and non-atopic patients with chronic severe asthma, and concentrations in these patients were higher than in normal controls. These observations are compatible with the hypothesis that IL-5 release occurs in these patients during a period of stable asthma despite systemic glucocorticoid therapy. 相似文献