全文获取类型
收费全文 | 557篇 |
免费 | 50篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 11篇 |
妇产科学 | 9篇 |
基础医学 | 99篇 |
口腔科学 | 19篇 |
临床医学 | 54篇 |
内科学 | 116篇 |
皮肤病学 | 24篇 |
神经病学 | 58篇 |
特种医学 | 18篇 |
外科学 | 38篇 |
综合类 | 4篇 |
预防医学 | 54篇 |
眼科学 | 14篇 |
药学 | 37篇 |
中国医学 | 3篇 |
肿瘤学 | 46篇 |
出版年
2024年 | 4篇 |
2023年 | 8篇 |
2022年 | 25篇 |
2021年 | 28篇 |
2020年 | 27篇 |
2019年 | 23篇 |
2018年 | 31篇 |
2017年 | 23篇 |
2016年 | 19篇 |
2015年 | 19篇 |
2014年 | 24篇 |
2013年 | 34篇 |
2012年 | 53篇 |
2011年 | 41篇 |
2010年 | 20篇 |
2009年 | 19篇 |
2008年 | 39篇 |
2007年 | 32篇 |
2006年 | 20篇 |
2005年 | 19篇 |
2004年 | 22篇 |
2003年 | 22篇 |
2002年 | 30篇 |
2001年 | 2篇 |
2000年 | 3篇 |
1999年 | 7篇 |
1997年 | 1篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1983年 | 1篇 |
1942年 | 1篇 |
1940年 | 1篇 |
1924年 | 1篇 |
1913年 | 1篇 |
排序方式: 共有608条查询结果,搜索用时 15 毫秒
11.
Jacob Bertram Springborg Karoline Kanstrup Springborg Bertil Romner 《Neurocritical care》2013,18(3):400-405
Introduction
Hyperthermia is common in brain-injured patients and associated with a worse outcome. As brain rather than body temperature reduction, theoretically, is the most important in cerebral protection, there is logic in targeting cooling at the brain. Selective brain cooling can, in theory, be obtained by cooling the skull or by heat loss from the upper airways. In this preliminary safety and efficacy study, we report clinical data from brain-injured patients who because of hyperthermia were treated with intranasal cooling.Methods
Nine intubated brain-injured patients with hyperthermia were treated using a prototype intranasal balloon system perfused with cold saline. Temperature in the cerebrum, esophagus, and bladder was monitored together with intracranial pressure.Results
In only two of nine patients, normothermia was reached in the esophagus and in only four of nine patients it was reached in the bladder. When normothermia was reached, the time to normothermia was delayed. In the brain, normothermia was reached in two of five patients after approximately 72 h. Median temperature curves from the first 72 h of cooling showed that normothermia was not reached in any of the three compartments. The temperature in the brain and bladder were on average 0.6 and 0.5 °C higher than in the esophagus. ICP increased with increasing brain temperature. We found no signs of clinical important injury to the nasal mucosa from the cold saline or pressure in the balloons.Conclusion
In brain-injured patients with hyperthermia, cooling with a prototype intranasal balloon system was clinically inadequate as the effect was delayed and not brain selective. 相似文献12.
13.
Timm Heinbokel Abdallah Elkhal Guangxiang Liu Karoline Edtinger Stefan G. Tullius 《Transplantation reviews (Orlando, Fla.)》2013,27(3):65-75
Increasing numbers of elderly transplant recipients and a growing demand for organs from older donors impose pressing challenges on transplantation medicine. Continuous and complex modifications of the immune system in parallel to aging have a major impact on transplant outcome and organ quality. Both, altered alloimmune responses and increased immunogenicity of organs present risk factors for inferior patient and graft survival. Moreover, a growing body of knowledge on age-dependent modifications of allorecognition and alloimmune responses may require age-adapted immunosuppression and organ allocation.Here, we summarize relevant aspects of immunosenescence and their possible clinical impact on organ transplantation. 相似文献
14.
Although the hippocampus had been traditionally thought to be exclusively involved in long‐term memory, recent studies raised controversial explanations why hippocampal activity emerged during short‐term memory tasks. For example, it has been argued that long‐term memory processes might contribute to performance within a short‐term memory paradigm when memory capacity has been exceeded. It is still unclear, though, whether neural activity in the hippocampus predicts visual short‐term memory (VSTM) performance. To investigate this question, we measured BOLD activity in 21 healthy adults (age range 19–27 yr, nine males) while they performed a match‐to‐sample task requiring processing of object‐location associations (delay period = 900 ms; set size conditions 1, 2, 4, and 6). Based on individual memory capacity (estimated by Cowan's K‐formula), two performance groups were formed (high and low performers). Within whole brain analyses, we found a robust main effect of “set size” in the posterior parietal cortex (PPC). In line with a “set size × group” interaction in the hippocampus, a subsequent Finite Impulse Response (FIR) analysis revealed divergent hippocampal activation patterns between performance groups: Low performers (mean capacity = 3.63) elicited increased neural activity at set size two, followed by a drop in activity at set sizes four and six, whereas high performers (mean capacity = 5.19) showed an incremental activity increase with larger set size (maximal activation at set size six). Our data demonstrated that performance‐related neural activity in the hippocampus emerged below capacity limit. In conclusion, we suggest that hippocampal activity reflected successful processing of object‐location associations in VSTM. Neural activity in the PPC might have been involved in attentional updating. © 2013 Wiley Periodicals, Inc. 相似文献
15.
16.
Henriette Löffler-Stastka Karoline Parth Franziska Lodermeier Roland Grassl Andreas Karwautz 《Psychotherapie Forum》2014,19(2):68-74
The issue of attachment has become increasingly important in research on fields such as developmental psychology, psychoanalysis but also infant research. This paper aims at discussing concepts from attachment theory, established by Bowlby, as well as object relations theory, concentrating on Klein’s and Bion’s contributions. These two theoretical models for understanding the specific individual emotional bond between an individual and its loved objects are elaborated and compared. Subsequently, the protective aspects of secure attachment are discussed and the harmful and psychically endangering qualities of insecure attachment are illustrated, showing that insecure attachment can be connected to psychopathology. Finally, further possibilities for research are pointed out and the potential of merging research methods from objects relations theory with attachment theory are discussed. 相似文献
17.
Jakub Trizuljak Wolfgang R. Sperr Lucie Nekvindová Hanneke O. Elberink Karoline V. Gleixner Aleksandra Gorska Magdalena Lange Karin Hartmann Anja Illerhaus Massimiliano Bonifacio Cecelia Perkins Chiara Elena Luca Malcovati Anna B. Fortina Khalid Shoumariyeh Mohamad Jawhar Roberta Zanotti Patrizia Bonadonna Francesca Caroppo Alexander Zink Massimo Triggiani Roberta Parente Nikolas von Bubnoff Akif S. Yavuz Hans Hägglund Mattias Mattsson Jens Panse Nadja Jäkel Alex Kilbertus Olivier Hermine Michel Arock David Fuchs Vito Sabato Knut Brockow Agnes Bretterklieber Marek Niedoszytko Björn van Anrooij Andreas Reiter Jason Gotlib Hanneke C. Kluin-Nelemans Jiri Mayer Michael Doubek Peter Valent 《Allergy》2020,75(8):1927-1938
18.
19.
de Paula Reis Michelle de Lima Daniely Alves Pauli Karoline Bach Andreotti Carlos Eduardo Linhares de Moraes André Luiz Soares Gonçalves Daniela Dib Navarro Italmar Teodorico Bueno Paulo Sérgio Alves Seixas Flavio Augusto Vicente Gasparotto Junior Arquimedes Lourenço Emerson Luiz Botelho 《Parasitology research》2018,117(5):1465-1471
Parasitology Research - Toxoplasmosis is a zoonosis of worldwide distribution. Currently, two drugs, pyrimethamine and sulfadiazine, are used as a reference in the treatment of toxoplasmosis, but... 相似文献
20.
Barbara Uhl Katharina T Prochazka Karoline Fechter Katrin Pansy Hildegard T Greinix Peter Neumeister Alexander JA Deutsch 《World journal of gastrointestinal oncology》2022,14(1):153-162
Approximately 8% of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphomas of mucosa-associated lymphoid tissue (MALT), also known as MALT lymphomas. These arise at a wide range of different extranodal sites, with most cases affecting the stomach, the lung, the ocular adnexa and the thyroid. The small intestine is involved in a lower percentage of cases. Lymphoma growth in the early stages is associated with long-lasting chronic inflammation provoked by bacterial infections (e.g., Helicobacter pylori or Chlamydia psittaci infections) or autoimmune conditions (e.g., Sjögren’s syndrome or Hashimoto thyroiditis). While these inflammatory processes trigger lymphoma cell proliferation and/or survival, they also shape the microenvironment. Thus, activated immune cells are actively recruited to the lymphoma, resulting in either direct lymphoma cell stimulation via surface receptor interactions and/or indirect lymphoma cell stimulation via secretion of soluble factors like cytokines. In addition, chronic inflammatory conditions cause the acquisition of genetic alterations resulting in autonomous lymphoma cell growth. Recently, novel agents targeting the microenvironment have been developed and clinically tested in MALT lymphomas as well as other lymphoid malignancies. In this review, we aim to describe the composition of the microenvironment of MALT lymphoma, the interaction of activated immune cells with lymphoma cells and novel therapeutic approaches in MALT lymphomas using immunomodulatory and/or microenvironment-targeting agents. 相似文献