全文获取类型
收费全文 | 2141篇 |
免费 | 153篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 107篇 |
妇产科学 | 74篇 |
基础医学 | 260篇 |
口腔科学 | 34篇 |
临床医学 | 208篇 |
内科学 | 466篇 |
皮肤病学 | 12篇 |
神经病学 | 226篇 |
特种医学 | 107篇 |
外科学 | 281篇 |
综合类 | 53篇 |
一般理论 | 1篇 |
预防医学 | 75篇 |
眼科学 | 45篇 |
药学 | 99篇 |
中国医学 | 11篇 |
肿瘤学 | 240篇 |
出版年
2023年 | 10篇 |
2022年 | 36篇 |
2021年 | 61篇 |
2020年 | 32篇 |
2019年 | 33篇 |
2018年 | 54篇 |
2017年 | 48篇 |
2016年 | 57篇 |
2015年 | 70篇 |
2014年 | 93篇 |
2013年 | 104篇 |
2012年 | 151篇 |
2011年 | 181篇 |
2010年 | 93篇 |
2009年 | 71篇 |
2008年 | 134篇 |
2007年 | 113篇 |
2006年 | 92篇 |
2005年 | 114篇 |
2004年 | 108篇 |
2003年 | 96篇 |
2002年 | 72篇 |
2001年 | 61篇 |
2000年 | 56篇 |
1999年 | 49篇 |
1998年 | 22篇 |
1997年 | 13篇 |
1996年 | 18篇 |
1995年 | 10篇 |
1994年 | 5篇 |
1993年 | 10篇 |
1992年 | 15篇 |
1991年 | 13篇 |
1990年 | 29篇 |
1989年 | 33篇 |
1988年 | 21篇 |
1987年 | 25篇 |
1986年 | 23篇 |
1985年 | 18篇 |
1984年 | 12篇 |
1982年 | 11篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1979年 | 11篇 |
1978年 | 6篇 |
1977年 | 5篇 |
1976年 | 2篇 |
1974年 | 7篇 |
1973年 | 6篇 |
1972年 | 4篇 |
排序方式: 共有2321条查询结果,搜索用时 15 毫秒
61.
62.
Joiner WM Lee JE Shelhamer M 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2007,181(2):307-320
The ability to make predictive saccadic eye movements is dependent on neural signals that anticipate the onset of a visual
target. We used a novel paradigm—based on the saccade-countermanding task—as a tool to investigate rhythm saccade pacing and
to provide information on the mechanisms of predictive timing. In particular, we examined the ability of normal subjects to
stop a sequence of periodically paced eye movements when cued by a stop signal that was presented at different times with
respect to the last target of the sequence (stop signal delay, SSD). The timing of the stop signal affected the ability to
stop the saccadic sequence (make a saccade to a central target rather than to the peripheral alternating targets) in different
ways, depending on the preceding tracking behavior. For the same SSD, subjects cancelled fewer trials during predictive tracking
(promoted by tracking targets alternating at a fast pacing rate, 1.0 Hz) than during reactive tracking (tracking alternating
targets at a low pacing rate, 0.2 Hz). In addition, on non-canceled trials, there was an increase in the delay of the corrective
saccade to the central target with increasing SSD for pacing at 0.2 Hz, but the timing of the corrective saccade remained
near constant for 1.0 Hz pacing. In examining the timing between movements, we estimate that the repetitive GO process that
drives the saccades during predictive tracking begins earlier and has a shorter duration than the repetitive GO process during reactive tracking. These behavioral results provide further insight into the initiation process of predictive responses. In particular,
the reduced reaction time and the corresponding short duration of the predictive process may result from a faster accumulation
of neuronal discharge to a relatively fixed threshold. 相似文献
63.
Although there may not be a direct association between oral hygiene and implant failure, oral hygiene must be maintained around implants in the edentulous mouth. Bacterial plaque on dentures can act as a reservoir for pathogens that cause respiratory disease. Unfortunately, many edentulous patients have poor oral hygiene. In this article, we describe the development of a brochure to educate patients wearing mandibular overdentures supported by 2 implants as a supplement to the dentist"s verbal instructions. Dental literature and several specialists were consulted during preparation of the brochure, which contains photographs accompanying oral hygiene instructions. It was sent to 25 participants who were subsequently called and questioned regarding its content and their oral hygiene habits. The 24 respondents found the brochure useful; most reported that they would keep the brochure for future reference and that they learned something new about how to maintain their implants properly. No one found the brochure too long or unclear. Most participants read the brochure entirely, rather than skimming it. The brochure is available to all clinicians who wish to incorporate this tool into their implant overdenture therapeutic approach. 相似文献
64.
Alexandre Tran Shannon M. Fernando Daniel I. McIsaac Bram Rochwerg Garrick Mok Andrew J.E. Seely Dalibor Kubelik Kenji Inaba Dennis Y. Kim Peter M. Reardon Jennifer Shen Peter Tanuseputro Kednapa Thavorn Kwadwo Kyeremanteng 《Canadian journal of surgery》2020,63(6):E598
BackgroundPrior studies of rapid response team (RRT) implementation for surgical patients have demonstrated mixed results with respect to reductions in poor outcomes. The aim of this study was to identify predictors of in-hospital mortality and hospital costs among surgical inpatients requiring RRT activation.MethodsWe analyzed data prospectively collected from May 2012 to May 2016 at The Ottawa Hospital. We included patients who were at least 18 years of age, who were admitted to hospital, who received either preoperative or postoperative care, and and who required RRT activation. We created a multivariable logistic regression model to describe mortality predictors and a multivariable generalized linear model to describe cost predictors.ResultsWe included 1507 patients. The in-hospital mortality rate was 15.9%. The patient-related factors most strongly associated with mortality included an Elixhauser Comorbidity Index score of 20 or higher (odds ratio [OR] 3.60, 95% confidence interval [CI] 1.96–6.60) and care designations excluding admission to the intensive care unit and cardiopulmonary resuscitation (OR 3.52, 95% CI 2.25–5.52). The strongest surgical predictors included neurosurgical admission (OR 2.09, 95% CI 1.17–3.75), emergent surgery (OR 2.04, 95% CI 1.37–3.03) and occurrence of 2 or more operations (OR 1.73, 95% CI 1.21–2.46). Among RRT factors, occurrence of 2 or more RRT assessments (OR 2.01, 95% CI 1.44–2.80) conferred the highest mortality. Increased cost was strongly associated with admitting service, multiple surgeries, multiple RRT assessments and medical comorbidity.ConclusionRRT activation among surgical inpatients identifies a population at high risk of death. We identified several predictors of mortality and cost, which represent opportunities for future quality improvement and patient safety initiatives. 相似文献
65.
Katie Mok Michael D Christian Sandra Nelson Lisa Burry 《The Canadian journal of hospital pharmacy》2014,67(3):213-219
Background
Current evidence suggests that administration of appropriate antibiotic therapy within 1 h after the onset of hypotension significantly improves mortality rates among patients with severe sepsis and septic shock.Objectives:
To determine the interval from recognition of severe sepsis or septic shock in inpatients to initial administration of antibiotic and to assess institutional compliance with the Surviving Sepsis Campaign’s recommendation for early antibiotic therapy.Methods:
A 6-month retrospective chart analysis was conducted to determine the interval from documented onset of hypotension to initial administration of antibiotic for patients with severe sepsis or septic shock. Patients who were admitted to a general medicine ward, a surgery ward, or the intensive care unit (ICU) of a 475-bed university-affiliated hospital and who met the criteria for severe sepsis or septic shock were eligible for inclusion. Patients who received antibiotics before meeting the criteria for severe sepsis or septic shock were excluded.Results:
Charts for 100 patients with severe sepsis or septic shock were reviewed. The mean age was 69.0 years (standard deviation 18.7 years), and 56% were men. The median interval from onset of severe sepsis or septic shock to administration of antibiotic was 4.00 h (interquartile range [IQR] 1.80–6.45 h). The median interval from the time a physician ordered an antibiotic to administration of the drug was 1.28 h (IQR 0.57–3.05 h). The interval between ordering and administration differed significantly for patients on the wards (5.67 h), those with onset in the ICU (4.00 h), and those with onset in the emergency department (3.28 h) (p = 0.039). The overall survival rate was 56%.Conclusion:
At the study hospital, the interval from onset of severe sepsis or septic shock to initial administration of antibiotic to inpatients exceeded the 1-h period recommended by the Surviving Sepsis Campaign. These results will be used as a baseline for future quality assurance and improvement initiatives aimed at minimizing the time to antibiotic administration for this group of patients, who are at high risk of death. 相似文献66.
Jose Paulo P. Lorenzo Ma. Hanna Monica Z. Sollano Evelyn O. Salido Julie Li-Yu Sandra A. Tankeh-Torres Ida Ayu Ratih Wulansari Manuaba Md Mujibur Rahman Binoy J. Paul Mo Yin Mok Monika De Silva Prasanta Padhan Ai Lee Lim Melvin Marcial Jennifer Jeanne Vicera Syed Atiqul Haq Sami Salman Chiranthi K. Liyanage Helen I. Keen Cheng Yew Kuang James Cheng-Chung Wei Rakhma Yanti Hellmi Charlie E. Chan Worawit Louthrenoo 《International journal of rheumatic diseases》2022,25(1):7-20
67.
68.
OBJECTIVE: To study the predictive factors for avascular necrosis (AVN) of
bone in patients with systemic lupus erythematosus (SLE). METHOD: The
records of 38 SLE patients who developed clinically apparent AVN during the
course of their disease were reviewed. Information on clinical
presentation, corticosteroid usage and autoantibody profiles was obtained,
and comparison was made between these patients and 143 consecutive control
SLE patients who did not have AVN. RESULTS: The point prevalence of AVN in
our SLE population was 12%. Patients with AVN, when compared with controls,
had a significantly higher incidence of neurological disease (39% vs 14%; P
< 0.001) and Cushingoid body habitus after steroid treatment (79% vs
53%; P = 0.004). The highest cumulative prednisolone dose in 1 and 4 months
was significantly higher in the AVN group than the controls (1.8 vs 1.1 and
4.5 vs 2.8 g, respectively; P < 0.01 in both) and showed a linear trend
with the incidence of AVN (chi2 test for trend, P < 0.01 in both). Lupus
anticoagulant was associated with AVN (P = 0.02, odds ratio 2.88 [1.14-
7.28]). Logistic regression analysis revealed that the highest cumulative
prednisolone dose administered in 4 months, the maximum and mean daily
prednisolone dosage, and the lupus anticoagulant were independent risk
factors for AVN. CONCLUSIONS: Corticosteroid remains the major predisposing
factor for AVN in SLE. Patients who require an initial high-dose steroid
for disease control are at risk of AVN, especially if they are positive for
the lupus anticoagulant or develop Cushingoid habitus after steroid
treatment. High-risk patients should be closely monitored so that early AVN
can be diagnosed by sensitive techniques such as magnetic resonance imaging
and radioisotope bone scanning.
相似文献
69.
Frontal and temporal contributions to understanding the iconic co‐speech gestures that accompany speech 下载免费PDF全文
Anthony Steven Dick Eva H. Mok Anjali Raja Beharelle Susan Goldin‐Meadow Steven L. Small 《Human brain mapping》2014,35(3):900-917
In everyday conversation, listeners often rely on a speaker's gestures to clarify any ambiguities in the verbal message. Using fMRI during naturalistic story comprehension, we examined which brain regions in the listener are sensitive to speakers' iconic gestures. We focused on iconic gestures that contribute information not found in the speaker's talk, compared with those that convey information redundant with the speaker's talk. We found that three regions—left inferior frontal gyrus triangular (IFGTr) and opercular (IFGOp) portions, and left posterior middle temporal gyrus (MTGp)—responded more strongly when gestures added information to nonspecific language, compared with when they conveyed the same information in more specific language; in other words, when gesture disambiguated speech as opposed to reinforced it. An increased BOLD response was not found in these regions when the nonspecific language was produced without gesture, suggesting that IFGTr, IFGOp, and MTGp are involved in integrating semantic information across gesture and speech. In addition, we found that activity in the posterior superior temporal sulcus (STSp), previously thought to be involved in gesture‐speech integration, was not sensitive to the gesture‐speech relation. Together, these findings clarify the neurobiology of gesture‐speech integration and contribute to an emerging picture of how listeners glean meaning from gestures that accompany speech. Hum Brain Mapp 35:900–917, 2014. © 2012 Wiley Periodicals, Inc. 相似文献
70.
Sook Hyon Ahn Ji Yeoun Lee Kyu-Chang Wang Sung-Hye Park Jung-Eun Cheon Ji Hoon Phi Seung-Ki Kim 《Child's nervous system》2014,30(2):345-350