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171.
Gil T; Castilla JA; Hortas ML; Redondo M; Samaniego F; Garrido F; Vergara F; Herruzo AJ 《Human reproduction (Oxford, England)》1998,13(2):296-301
Using flow cytometry, we studied the expression of the CD16 antigen by
lymphocytes present in human semen samples from three groups of patients:
60 fertile men attending for vasectomy, 60 sterile patients without
antisperm antibodies (ASA) and 18 immunological sterile patients with ASA
in their ejaculate. No significant difference was found in the
concentration of leukocytes or subpopulations of these cells (monocytes,
lymphocytes and granulocytes) between fertile, sterile without ASA and
immunological sterile groups. However, we detected a predominance of
macrophages/monocytes within the population of seminal leukocytes. No
statistically significant difference was found in the absolute number of T
and B lymphocytes between the three groups studied. However, a significant
increase in the number of CD16+ lymphocytes was observed in the ejaculate
of sterile patients with ASA as compared to the other groups. This finding
might establish an important parameter in the follow-up and prognosis of
patients with immunological sterility.
相似文献
172.
Parenteral administration of follicle stimulating hormone (FSH) has been
shown to lower luteinizing hormone (LH) concentrations in women undergoing
ovulation induction. This study was designed to explore the physiological
mechanism of this effect. Seven healthy women were recruited into a
double-blind placebo-controlled study. LH secretion, after the
administration of variable i.v. boluses (37.5, 75 and 150 IU) of
recombinant FSH (Gonal-F), was evaluated. LH was measured at 10 min
intervals for 2 h before and 4 h after the FSH/placebo infusion. LH pulse
frequency and amplitude were evaluated and there was no significant
difference between control and trial cycles for each subject. A linear
regression analysis revealed that in the group receiving 150 IU FSH, the
mean plasma LH concentration decreased significantly due to a reduction
tonic LH secretion. This could be a result of the suppression of secretion
or an alteration of clearance. This decrease was not seen in the other
dosage groups, revealing that above a dosage threshold, FSH reduced
non-pulsatile LH secretion. Therefore the effect of FSH in this study
exposed the likely presence of two components of LH concentration: an
FSH-sensitive, non-pulsatile tonic secretion and a gonadotrophin-releasing
hormone-stimulated, pulsatile release that is unaffected by FSH. Although
an indirect effect involving ovarian regulation is not excluded, the
rapidity of the effect suggests that FSH acts directly on the pituitary
gland.
相似文献
173.
天保宁胶囊治疗80例冠心病的临床效果 总被引:1,自引:0,他引:1
为了在众多银杏叶制品中,选取对冠心病具有可靠疗铲的制剂。方法:治疗组随机采取80例冠心病患者服用天保宁胶囊制剂,对照为20例冠心病患者,服用复方丹参片,在正常剂量的基础一服用2个疗程。结果:治疗组症状消失率为91.3%,心电图有效率为66.35,血脂治疗前后也有较显著性差异。对照组症状消失率为70%,心电图有效率为45.0%,血脂治疗前后指标无明显改善。 相似文献
174.
175.
Idiopathic chronic ulcerative enteritis (ICUE) is considered by some physicians to be a variant of sprue. Two patients being treated at our hospital for nonspecific abdominal symptoms had abnormal findings from a small-bowel series; at surgery, an ulcerating process involving the jejunum was found. Clinical, radiological, and pathological findings in these cases suggest that ICUE is a distinct entity. 相似文献
176.
R De Pasquale MR Nasca ML Musumeci G Micali 《Journal of the European Academy of Dermatology and Venereology》2002,16(4):387-389
Elastosis perforans serpiginosa (EPS) is a rare perforating dermatosis in which elastic fibers extrude from the papillary dermis producing umbilicated papules, characteristically arranged to form arciform or serpiginous patterns on the skin. It can be observed in patients with Down's syndrome, in whom in some cases the disease has been reported to be more widespread and to run a longer course. We present the case of a 20-year-old girl with Down's syndrome, hypothyroidism, acne and hypertrichosis, who had a 2-year history of multiple atrophic lesions with an arciform pattern on the distal extensor portions of both thighs, histologically showing the typical features of EPS. 相似文献
177.
178.
Aim: To compare the decrease in total serum bilirubin (TSB) concentration during conventional phototherapy in infants treated in supine position exclusively versus infants alternated between exposure in supine and prone position every third hour. Moreover, to survey current practice patterns in two Scandinavian countries as far as alternating exposure. Methods: A total of 112 infants with non‐haemolytic hyperbilirubinaemia, but otherwise healthy, and a gestational age ≥33 weeks were randomized to one of the treatment groups. All infants received phototherapy for 24 h. TSB was measured at start of phototherapy and after 12 and 24 h of treatment. Questionnaires about routines for position changes in infants during phototherapy were sent to all 41 neonatal departments in Denmark and Norway. Results: No statistically significant differences in the decrease in TSB were observed between the two treatment groups: at 12 h of therapy, TSB decreased 32% in both groups and at 24 h 49% and 50%, respectively. In two‐thirds of Danish and Norwegian departments, the infants were routinely turned during phototherapy, most often every third hours. Conclusion: The decrease in TSB was not significantly associated with positioning of the infant during conventional phototherapy. Alternating exposure is widely practiced in Scandinavia but is unnecessary. 相似文献
179.
F Núñez C Martínez‐Costa F Soler R Guijarro‐Martínez ML Castelló J Brines 《Acta paediatrica (Oslo, Norway : 1992)》2010,99(9):1434-1436
Background: Congenital arteriovenous fistulas are exceptional in childhood and imply a therapeutic challenge. Case report: A 9‐month‐old female infant was studied for cephalocorporal disproportion, hypotonia, progressive muscular atrophy and hyperreflexia. Computed tomography of the brain and electroencephalography were normal. Electromyographic patterns suggested proximal myopathic involvement. A continuous murmur with systolic reinforcement was audible in the neck. Angioresonance detected intracranial aneurysmal dilatations behind the bulbo‐medullary junction and cerebral panangiography evidenced a direct vertebrovertebral fistula with extra‐ and intra‐cranial varices and extreme medullary compression. Occlusion of the afferent vessel to the aneurismal sack was successfully achieved with a mixture of Histoacryl and 75% lipiodol via a microcatheter. Conclusion: Clinical signs of an arteriovenous fistula may be atypical. Considerable cephalocorporal disproportion and a bruit in the cervical or retromastoidal regions must suggest its existence. Complete obliteration with endovascular embolization permits somatic and neurological recovery. 相似文献
180.
Identification by STS PCR screening of a microdeletion in Xp21.3-22.1 associated with non-specific mental retardation 总被引:3,自引:0,他引:3
Billuart P; Vinet MC; des Portes V; Llense S; Richard L; Moutard ML; Recan D; Bruls T; Bienvenu T; Kahn A; Beldjord C; Chelly J 《Human molecular genetics》1996,5(7):977-979
X-linked non-specific mental retardation (MRX) is a heterogeneous condition
in which mental retardation (MR) appears to be the only consistent
manifestation. The genetic and phenotypic heterogeneity exclude any
possibility of pooling families and, therefore, of fine- mapping the
related disease genes. In order to identify genomic critical regions
involved in the MRX condition assigned to Xp21.3-22.1 region, we have
implemented the PCR screening of non fragile X MR patients for the presence
of deletions in this region. The amplification by PCR of 12 markers located
between POLA and DXS704 using genomic DNA from 192 MR males led to the
identification, in a 9 year old mentally retarded boy, of a microdeletion
which extends from DXS1202 to DXS1065. None of the known genes, POLA, MAGE
genes cluster, DAX1, GK and DMD, that map in the Xp21.3-22.1 region is
affected by this deletion. This approach, which could easily be applied to
several other MRX loci, allowed not only a confirmation of the presence of
a potential locus in Xp21.3-22.1 involved in non-specific mental
retardation, but also a better definition of the genomic critical region
corresponding to this locus.
相似文献