全文获取类型
收费全文 | 2695篇 |
免费 | 132篇 |
国内免费 | 99篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 49篇 |
妇产科学 | 89篇 |
基础医学 | 432篇 |
口腔科学 | 98篇 |
临床医学 | 251篇 |
内科学 | 445篇 |
皮肤病学 | 124篇 |
神经病学 | 231篇 |
特种医学 | 97篇 |
外科学 | 416篇 |
综合类 | 28篇 |
预防医学 | 73篇 |
眼科学 | 59篇 |
药学 | 221篇 |
中国医学 | 33篇 |
肿瘤学 | 266篇 |
出版年
2023年 | 13篇 |
2022年 | 48篇 |
2021年 | 80篇 |
2020年 | 38篇 |
2019年 | 50篇 |
2018年 | 51篇 |
2017年 | 47篇 |
2016年 | 70篇 |
2015年 | 107篇 |
2014年 | 119篇 |
2013年 | 172篇 |
2012年 | 227篇 |
2011年 | 225篇 |
2010年 | 140篇 |
2009年 | 122篇 |
2008年 | 159篇 |
2007年 | 196篇 |
2006年 | 125篇 |
2005年 | 130篇 |
2004年 | 106篇 |
2003年 | 83篇 |
2002年 | 74篇 |
2001年 | 81篇 |
2000年 | 74篇 |
1999年 | 66篇 |
1998年 | 42篇 |
1997年 | 31篇 |
1996年 | 32篇 |
1995年 | 26篇 |
1994年 | 24篇 |
1993年 | 17篇 |
1992年 | 22篇 |
1991年 | 18篇 |
1990年 | 17篇 |
1989年 | 17篇 |
1988年 | 19篇 |
1987年 | 14篇 |
1986年 | 7篇 |
1985年 | 6篇 |
1984年 | 7篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1974年 | 3篇 |
1971年 | 1篇 |
1968年 | 1篇 |
1966年 | 1篇 |
1964年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有2926条查询结果,搜索用时 0 毫秒
81.
82.
83.
Jiyong Kwak Hye-Jin Shin Se-Hoon Kim Jin-Kyoung Shim Ji-Hyun Lee Yong-Min Huh Eui-Hyun Kim Eun-Kyung Park Jong Hee Chang Sun Ho Kim Yong-Kil Hong Dong-Seok Kim Su-Jae Lee Seok-Gu Kang 《Child's nervous system》2013,29(12):2229-2239
Purpose
It has been reported that cancer stem cells (CSCs) can be isolated from primitive neuroectodermal tumor (PNET) specimens. Moreover, mesenchymal stem-like cells (MSLCs) have been isolated from Korean glioma specimens. Here, we tested whether tumor spheres and MSLCs can be simultaneously isolated from a single PNET specimen, a question that has not been addressed.Methods
We isolated single-cell suspensions from PNET specimens, then cultured these cells using methods for MSLCs or CSCs. Cultured cells were analyzed for surface markers of CSCs using immunocytochemistry and for surface markers of bone marrow-derived mesenchymal stem cells (BM-MSCs) using fluorescence-activated cell sorting (FACS). Tumor spheres were exposed to neural differentiation conditions, and MSLCs were exposed to mesenchymal differentiation conditions. Possible locations of MSLCs within PNET specimens were determined by immunofluorescence analysis of tumor sections.Results
Cells similar to tumor spheres and MSLCs were independently isolated from one of two PNET specimens. Spheroid cells, termed PNET spheres, were positive for CD133 and nestin, and negative for musashi and podoplanin. PNET spheres were capable of differentiation into immature neural cells and astrocytes, but not oligodendrocytes or mature neural cells. FACS analysis revealed that adherent cells isolated from the same PNET specimen, termed PNET-MSLCs, had surface markers similar to BM-MSCs. These cells were capable of mesenchymal differentiation. Immunofluorescence labeling indicated that some CD105+ cells might be closely related to endothelial cells and pericytes.Conclusion
We showed that both tumor spheres and MSLCs can be isolated from the same PNET specimen. PNET-MSLCs occupied a niche in the vicinity of the vasculature and could be a source of stroma for PNETs. 相似文献84.
85.
Different pattern of viral infections and clinical outcomes in patient with acute exacerbation of chronic obstructive pulmonary disease and chronic obstructive pulmonary disease with pneumonia 下载免费PDF全文
Ho‐Cheol Kim Sang‐Ho Choi Jin‐Won Huh Heungsup Sung Sang Bum Hong Chae‐Man Lim Younsuck Koh 《Journal of medical virology》2016,88(12):2092-2099
86.
Lee WS Chun HK Lee WY Yun SH Yun H Cho YB Kang WK Park YS Huh SJ Ahn YC Park W 《Yonsei medical journal》2007,48(5):827-832
PURPOSE: The clinical features, treatment modality approaches in clinical practice, and prognostic factors for anal canal carcinoma patients were retrospectively analyzed. MATERIALS AND METHODS: Between October 1994 and December 2005, 50 patients with anal canal cancer were treated at Samsung Medical Center, Seoul, Korea. RESULTS: After a median follow up of 37.8 months (range, 6.6-136.1 months), the 5-year and 10-year survival rates for the 38 patients with early and locally advanced squamous and cloacogenic carcinoma (squamous cell carcinoma and cloacogenic carcinoma) were 74.8% and 66.5%, respectively. The 5-year survival and disease-free survival rates (DFS) of the 31 patients who received chemoradiation therapy (CRT) were 83.6% and 74.3%, respectively. The overall and DFS could not be determined for the adenocarcinoma group due to the small number of cases (n=8). Univariate analysis showed that tumor size (p=0.04) and inguinal node status (p=0.04) significantly influenced patient survival in patients with squamous cell and cloacogenic carcinomas. Furthermore, univariate analysis also showed that, inguinal node status influenced patient survival in the adenocarcinoma group. Multivariate analysis showed that inguinal node metastasis is a single independent prognostic variable for survival (p=0.04) in patients with squamous cell and cloacogenic carcinomas. CONCLUSION: Combined CRT has been adopted as standard treatment with outcomes that are comparable to those reported in randomized clinical trials. Due to the rarity and complexity of anal canal carcinoma, interdepartmental cooperation is required for disease treatment. Thus, proper treatment of patients should incorporate a team-approach and should be available to as many patients as possible. 相似文献
87.
88.
89.
Park Ji-Ho Lee Hyuk-Joon Oh Seung-Young Park Shin-Hoo Berlth Felix Son Young-Gil Kim Tae Han Huh Yeon-Ju Yang Jun-Young Lee Kyung-Goo Suh Yun-Suhk Kong Seong-Ho Yang Han-Kwang 《World journal of surgery》2020,44(5):1569-1577
World Journal of Surgery - Scarce data are available on the characteristics of postoperative organ failure (POF) and mortality after gastrectomy. We aimed to describe the causes of organ failure... 相似文献
90.
Evaluating the safety and efficacy of the 1,440‐nm laser in the treatment of photodamage in Asian skin 下载免费PDF全文
Shoshana Marmon MD PhD Samantha Y. N. Shek MBBS C.K. Yeung MD MBBS Nicola P.Y. Chan MRCP Johnny CY Chan MBBS Henry H.L. Chan MD PhD FRCP 《Lasers in surgery and medicine》2014,46(5):375-379