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81.
Carnitine metabolism during starvation was studied in adult lean and obese female Zucker rats. Comparisons were made between rats starved for 0, 3, 6 or 9 d. Total plasma carnitine was not affected by obesity or starvation, but free plasma carnitine decreased with starvation. Plasma acid-soluble acylcarnitine was lower in obese than in lean rats, and increased with starvation in both lean and obese rats. Plasma acid-insoluble acylcarnitine was not affected by obesity but increased with starvation. Liver free and acid-soluble acylcarnitine were lower in obese rats than lean rats, and starvation increased liver free carnitine and acid-insoluble acylcarnitine. Free carnitine was lower in muscle from obese rats than from lean rats. In kidney, free carnitine decreased during starvation. Heart carnitine was not affected by obesity or starvation. Urinary free carnitine and acid-soluble acylcarnitine clearance decreased during starvation. These studies indicate that: 1) lean and obese Zucker rats conserve carnitine during starvation; and 2) the decreases in liver carnitine concentration reflect the loss of cellular constituents rather than increases in total hepatic carnitine. 相似文献
82.
83.
Guidelines for international collaborative research 总被引:2,自引:1,他引:1
OBJECTIVE: As the global village becomes a reality, there is an increasing
need to conduct international collaborative studies in family practice. A
workshop at the WONCA meeting in Hong Kong used international attendees to
produce a set of guidelines for international research. METHODS: At the
workshop four completed international projects, each using a different
strategy, were presented so that common themes might become apparent. The
themes were then discussed and guidelines emerged from the process.
RESULTS: Seven guidelines emerged for consideration before embarking on an
international collaborative research project in family medicine. The
guidelines deal with the characteristics of the research question and the
importance of communication. The need for simple, brief methods of data
collection, funding and pilot testing were identified. CONCLUSION: The
question must be relevant to all participants to maintain interest and
measurement tools must be validated to understand the impact of cultural
differences in understanding.
相似文献
84.
Colorectal metastases to the liver: selective chemoembolization 总被引:6,自引:0,他引:6
85.
86.
HAKAN SENTURK SEVAL ERDINÇCL MUSTAFA TASYUREKLI ALI MERT MACIT ARVAS CIHAT SEN 《Journal of gastroenterology and hepatology》1996,11(7):617-620
Rare causes of liver dysfunction in pregnancy may pose a challenge to the consulting gastroenterologist or hepatologist from both the diagnostic and therapeutic standpoints. We describe here liver function abnormalities in a case of hyperreactio luteinalis with light and electron microscopic findings. 相似文献
87.
To calculate the centre of pressure using piezoelectric force plates mounted on pads, no net tensile stresses may be imposed on the surface of the plate. This condition is violated when stairs are attached to the plates, unless the plates are preloaded. Typical shear forces encountered when climbing stairs were used to determine required preloads of approximately 16.4 N/cm step height. Vertical and horizontal loads were applied at known locations on the steps, and points of application were calculated. Deviations were within ± 3 mm. The effect of point of application inaccuracy on calculated joint moments is considerable. A 2 cm medial shift in the point of application resulted in calculated peak knee abduction/adduction moment errors of 35%. 相似文献
88.
Robert J. Walter Bernard Tandler Charles L. Hoppel 《Anatomical record (Hoboken, N.J. : 2007)》1980,197(3):289-295
The ultrastructural and oxidative metabolic effects of D-penicillamine were examined in hepatocytes of mice fed various concentrations of the drug for periods up to 11 days. In virtually all animals studied, membranous material in the form of whorls, sheaves, and irregular networks was observed in some bile canaliculi. In several mice a few mitochondria were substantially enlarged, with diameters of 4-6 μm. In other animals some mitochondria became quite elongated, measuring 10 μm in length but only 0.5 μm in width. Certain mitochondria had small deposits of dense material in their outer compartment. Lysosomes contained numerous small dense particles; aggregates of these particles were also observed free in the cytosol. Despite these alterations, the vast majority of hepatocytes showed no changes whatsoever. Study of isolated hepatic mitochondria derived from the experimental animals showed no alterations in oxidative metabolism. It may be concluded that, unlike other copper-chelating agents, D-penicillamine has little significant morphological and biochemical effect on mouse hepatocytes, even when its concentration exceeds standard clinical dosages. 相似文献
89.
M. Araya J. Espinoza B. Zegers S. Cruchet O. Brunser D. Humphreys CL Fernandez 《Acta paediatrica (Oslo, Norway : 1992)》1996,85(10):1213-1216
To test the hypothesis that the increased health risk of children selected by a previously calculated and validated predictive model is associated with some maternal psychological characteristics, the universe of 107 mothers of children selected by this model was evaluated by means of Goldberg's General Health Questionnaire (GHQ-30), Raven (Ra) and Rorschach (Ro) tests; 37.4% were cases according to GHQ-30, 80.9% were < 50th percentile in Ra and 85% exhibited deviant responses in Ro tests. Children whose mother's IQ was < 50th percentile suffered more episodes of total morbidity (Tm) and of diarrhoea (p = 0.0364). Children whose mothers were normal in Ro had less Tm (p = 0.0364) and fewer respiratory symptoms (p = 0.0300) and tended to have less diarrhoea (p = 0.0690). In poor urban families in Santiago psychological maternal characteristics are associated with an increased health risk for the infants. Supportive programmes should consider both biological characteristics of the infants and maternal psychological needs. 相似文献
90.
A calcified adenocarcinoma of the lung with very high CT numbers 总被引:4,自引:0,他引:4