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991.
Belt EJ te Velde EA Krijgsman O Brosens RP Tijssen M van Essen HF Stockmann HB Bril H Carvalho B Ylstra B Bonjer HJ Meijer GA 《Annals of surgical oncology》2012,19(4):1222-1230
Background
Lymph node (LN) yield in colon cancer resection specimens is an important indicator of treatment quality and has especially in early-stage patients therapeutic implications. However, underlying disease mechanisms, such as microsatellite instability (MSI), may also influence LN yield, as MSI tumors are known to exhibit more prominent lymphocytic antitumor reactions. The aim of the present study was to investigate the association of LN yield, MSI status, and recurrence rate in colon cancer.Methods
Clinicopathological data and tumor samples were collected from 332 stage II and III colon cancer patients. DNA was isolated and PCR-based MSI analysis performed. LN yield was defined as “high” when 10 or more LNs were retrieved and “low” in case of fewer than 10 LNs.Results
Tumors with high LN yield were significantly associated with the MSI phenotype (high LN yield: 26.3% MSI tumors vs low LN yield: 15.1% MSI tumors; P = .01), mainly in stage III disease. Stage II patients with high LN yield had a lower recurrence rate compared with those with low LN yield. Patients with MSI tumors tended to develop fewer recurrences compared with those with MSS tumors, mainly in stage II disease.Conclusions
In the present study, high LN yield was associated with MSI tumors, mainly in stage III patients. Besides adequate surgery and pathology, high LN yield is possibly a feature caused by biologic behavior of MSI tumors. 相似文献992.
993.
The National CT Colonography Trial: assessment of accuracy in participants 65 years of age and older
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996.
Newton RL Han M H Dubbert PM Johnson WD Hickson DA Ainsworth B Carithers T Taylor H Wyatt S Tudor-Locke C 《The international journal of behavioral nutrition and physical activity》2012,9(1):44
ABSTRACT: BACKGROUND: This study investigated the number of pedometer assessment occasions required to establish habitual physical activity in African American adults. METHODS: African American adults (mean age 59.9 +/- 0.60 years; 59 % female) enrolled in the Diet and Physical Activity Substudy of the Jackson Heart Study wore Yamax pedometers during 3-day monitoring periods, assessed on two to three distinct occasions, each separated by approximately one month. The stability of pedometer measured PA was described as differences in mean steps/day across time, as intraclass correlation coefficients (ICC) by sex, age, and body mass index (BMI) category, and as percent of participants changing steps/day quartiles across time. RESULTS: Valid data were obtained for 270 participants on either two or three different assessment occasions. Mean steps/day were not significantly different across assessment occasions (p values > 0.456). The overall ICCs for steps/day assessed on either two or three occasions were 0.57 and 0.76, respectively. In addition, 85 % (two assessment occasions) and 76 % (three assessment occasions) of all participants remained in the same steps/day quartile or changed one quartile over time. CONCLUSION: The current study shows that an overall mean steps/day estimate based on a 3-day monitoring period did not differ significantly over 4 - 6 months. The findings were robust to differences in sex, age, and BMI categories. A single 3-day monitoring period is sufficient to capture habitual physical activity in African American adults. 相似文献
997.
Saskia van Vugt Lidewij Broekhuizen Nicolaas Zuithoff Pim de Jong Christopher Butler Kerenza Hood Samuel Coenen Herman Goossens Paul Little Jordi Almirall Francesco Blasi Slawomir Chlabicz Mel Davies Maciek Godycki-Cwirko Helena Hupkova Janko Kersnik Arthur Mierzecki Sigvard M?lstad Michael Moore Tom Schaberg An De Sutter Antoni Torres Pia Touboul Theo Verheij On behalf of the GRACE Project Group 《Annals of family medicine》2012,10(6):510-515
PURPOSE
Imaging may produce unexpected or incidental findings with consequences for patients and ordering of future investigations. Chest radiography in patients with acute cough is among the most common reasons for imaging in primary care, but data on associated incidental findings are lacking. We set out to describe the type and prevalence of incidental chest radiography findings in primary care patients with acute cough.METHODS
We report on data from a cross-sectional study in 16 European primary care networks on 3,105 patients with acute cough, all of whom were undergoing chest radiography as part of a research study workup. Apart from assessment for specified signs of pneumonia and acute bronchitis, local radiologists were asked to evaluate any additional finding on the radiographs. For the 2,823 participants with good-quality chest radiographs, these findings were categorized according to clinical relevance based on previous research evidence and analyzed for type and prevalence by network, sex, age, and smoking status.RESULTS
Incidental findings were reported in 19% of all participants, and ranged from 0% to 25% by primary care network, with the network being an independent contributor (P <.001). Of all participants 3% had clinically relevant incidental findings. Suspected nodules and shadows were reported in 1.8%. Incidental findings were more common is older participants and smokers (P <. 001).CONCLUSIONS
Clinically relevant incidental findings on chest radiographs in primary care adult patients with acute cough are uncommon, and prevalence varies by setting.Key words: cough, lung/radiography, primary care, incidental findings 相似文献998.
Spike protein fusion peptide and feline coronavirus virulence 总被引:1,自引:0,他引:1
Chang HW Egberink HF Halpin R Spiro DJ Rottier PJ 《Emerging infectious diseases》2012,18(7):1089-1095
Coronaviruses are well known for their potential to change their host or tissue tropism, resulting in unpredictable new diseases and changes in pathogenicity; severe acute respiratory syndrome and feline coronaviruses, respectively, are the most recognized examples. Feline coronaviruses occur as 2 pathotypes: nonvirulent feline enteric coronaviruses (FECVs), which replicate in intestinal epithelium cells, and lethal feline infectious peritonitis viruses (FIPVs), which replicate in macrophages. Evidence indicates that FIPV originates from FECV by mutation, but consistent distinguishing differences have not been established. We sequenced the full genome of 11 viruses of each pathotype and then focused on the single most distinctive site by additionally sequencing hundreds of viruses in that region. As a result, we identified 2 alternative amino acid differences in the putative fusion peptide of the spike protein that together distinguish FIPV from FECV in >95% of cases. By these and perhaps other mutations, the virus apparently acquires its macrophage tropism and spreads systemically. 相似文献
999.
Bertrand Fouks Philipp Brand Hung N. Nguyen Jacob Herman Francisco Camara Daniel Ence Darren E. Hagen Katharina J. Hoff Stefanie Nachweide Lars Romoth Kimberly K.O. Walden Roderic Guigo Mario Stanke Giuseppe Narzisi Mark Yandell Hugh M. Robertson Nikolaus Koeniger Panuwan Chantawannakul Michael C. Schatz Kim C. Worley Gene E. Robinson Christine G. Elsik Olav Rueppell 《Genome research》2021,31(7):1203
1000.
Berendsen RR Kolfschoten NE de Jong VM Frima H Daanen HA Anema HA 《Nederlands tijdschrift voor geneeskunde》2012,156(25):A4702
Frostbite injuries rarely occur in healthy Dutch persons. However, as the number of people engaging in winter and outdoor activities and travelling to high altitudes increases, the risk of frostbite also increases. Frostbite is a cold-induced injury which results from two processes: freezing and microvascular occlusion. Adequate first aid, which focuses on the prevention of refreezing and mechanical injury, and rapid rewarming together with the administration of ibuprofen, are of the greatest importance for limiting eventual tissue damage. Iloprost infusion and possibly (r)tPA are indicated if a patient presents within 24 hours after the tissue has thawed and the injury is such that severe morbidity can be expected. If the patient presents after this time period, hyperbaric oxygen therapy may be considered; however, the evidence available on this type of treatment is limited. 相似文献