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61.
Paul S. Nabity PhD Carlos A. Jaramillo MD PhD Patricia A. Resick PhD Cindy A. McGeary PhD Blessen C. Eapen MD Casey L. Straud PsyD Willie J. Hale PhD Timothy T. Houle PhD Brett T. Litz PhD Jim Mintz PhD Donald B. Penzien PhD Stacey Young-McCaughan RN PhD Terence M. Keane PhD Alan L. Peterson PhD Donald D. McGeary PhD Consortium to Alleviate PTSD 《Headache》2021,61(9):1334-1341
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Hale Sarah Freed Benjamin H. 《The international journal of cardiovascular imaging》2021,37(7):2149-2150
The International Journal of Cardiovascular Imaging - 相似文献
64.
Sener G Paskaloglu K Toklu H Kapucu C Ayanoglu-Dulger G Kacmaz A Sakarcan A 《Journal of pineal research》2004,36(4):232-241
Chronic renal failure (CRF) is associated with oxidative stress that promotes production of reactive oxygen species (ROS). Melatonin, the chief secretory product of the pineal gland, was recently found to be a potent free radical scavenger and antioxidant. The aim of this study was to examine the role of melatonin in protecting the aorta, heart, corpus cavernosum, lung, diaphragm, and kidney tissues against oxidative damage in a rat model of CRF, which was induced by five of six nephrectomy. Male Wistar albino rats were randomly assigned to either the CRF group or the sham-operated control group, which had received saline or melatonin (10 mg/kg, i.p.) for 4 wk. CRF was evaluated by serum blood urea nitrogen (BUN) level and creatinine measurements. Aorta and corporeal tissues were used for contractility studies, or stored along with heart, lung, diaphragm, and kidney tissues for the measurement of malondialdehyde (MDA, an index of lipid peroxidation), protein carbonylation (PC, an index for protein oxidation), and glutathione (GSH) levels (a key antioxidant). Plasma MDA, PC, and GSH levels and erythrocytic superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were studied to evaluate the changes of antioxidant status in CRF. In the CRF group, the contraction and the relaxation of aorta and corpus cavernosum samples decreased significantly compared with controls (P < 0.05-0.001). Melatonin treatment of the CRF group restored these responses. In the CRF group, there were significant increases in tissue MDA and PC levels in all tissues with marked reductions in GSH levels compared with controls (P < 0.05-0.001). In the plasma, while MDA and PC levels increased, GSH, SOD, CAT, and GSH-Px activities were reduced. Melatonin treatment reversed these effects as well. In this study, the increase in MDA and PC levels and the concomitant decrease in GSH levels of tissues and plasma and also SOD, CAT, GSH-Px activities of plasma demonstrate the role of oxidative mechanisms in CRF-induced tissue damage, and melatonin, via its free radical scavenging and antioxidant properties, ameliorates oxidative organ injury. CRF-induced dysfunction of the aorta and corpus cavernosum of rats was reversed by melatonin treatment. Thus, supplementing CRF patients with adjuvant therapy of melatonin may have some benefit. 相似文献
65.
Valerie A. Gerriets Rigel J. Kishton Amanda G. Nichols Andrew N. Macintyre Makoto Inoue Olga Ilkayeva Peter S. Winter Xiaojing Liu Bhavana Priyadharshini Marta E. Slawinska Lea Haeberli Catherine Huck Laurence A. Turka Kris C. Wood Laura P. Hale Paul A. Smith Martin A. Schneider Nancie J. MacIver Jason W. Locasale Christopher B. Newgard Mari L. Shinohara Jeffrey C. Rathmell 《The Journal of clinical investigation》2015,125(1):194-207
Activation of CD4+ T cells results in rapid proliferation and differentiation into effector and regulatory subsets. CD4+ effector T cell (Teff) (Th1 and Th17) and Treg subsets are metabolically distinct, yet the specific metabolic differences that modify T cell populations are uncertain. Here, we evaluated CD4+ T cell populations in murine models and determined that inflammatory Teffs maintain high expression of glycolytic genes and rely on high glycolytic rates, while Tregs are oxidative and require mitochondrial electron transport to proliferate, differentiate, and survive. Metabolic profiling revealed that pyruvate dehydrogenase (PDH) is a key bifurcation point between T cell glycolytic and oxidative metabolism. PDH function is inhibited by PDH kinases (PDHKs). PDHK1 was expressed in Th17 cells, but not Th1 cells, and at low levels in Tregs, and inhibition or knockdown of PDHK1 selectively suppressed Th17 cells and increased Tregs. This alteration in the CD4+ T cell populations was mediated in part through ROS, as N-acetyl cysteine (NAC) treatment restored Th17 cell generation. Moreover, inhibition of PDHK1 modulated immunity and protected animals against experimental autoimmune encephalomyelitis, decreasing Th17 cells and increasing Tregs. Together, these data show that CD4+ subsets utilize and require distinct metabolic programs that can be targeted to control specific T cell populations in autoimmune and inflammatory diseases. 相似文献
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Jannine D. Cody Courtney Sebold Patricia Heard Erika Carter Bridgette Soileau Minire Hasi-Zogaj Annice Hill David Rupert Brian Perry Louise O'Donnell Jon Gelfond Jack Lancaster Peter T. Fox Daniel E. Hale 《American journal of medical genetics. Part C, Seminars in medical genetics》2015,169(3):265-280
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Sheri A. Hale Andrea Fergus Rachel Axmacher Kimberly Kiser 《Journal of Athletic Training》2014,49(2):181-191
Context:
Bilateral improvements in postural control have been reported among individuals with acute lateral ankle sprains and individuals with chronic ankle instability (CAI) when only the unstable ankle is rehabilitated. We do not know if training the stable ankle will improve function on the unstable side.Objective:
To explore the effects of a unilateral balance-training program on bilateral lower extremity balance and function in individuals with CAI when only the stable limb is trained.Design:
Cohort study.Setting:
University clinical research laboratory.Patients or Other Participants:
A total of 34 volunteers (8 men, 26 women; age = 24.32 ± 4.95 years, height = 167.01 ± 9.45 cm, mass = 77.54 ± 23.76 kg) with CAI were assigned to the rehabilitation (n = 17) or control (n = 17) group. Of those, 27 (13 rehabilitation group, 14 control group) completed the study.Intervention(s):
Balance training twice weekly for 4 weeks.Main Outcome Measure(s):
Foot and Ankle Disability Index (FADI), FADI Sport (FADI-S), Star Excursion Balance Test, and Balance Error Scoring System.Results:
The rehabilitation and control groups differed in changes in FADI-S and Star Excursion Balance Test scores over time. Only the rehabilitation group improved in the FADI-S and in the posteromedial and anterior reaches of the Star Excursion Balance Test. Both groups demonstrated improvements in posterolateral reach; however, the rehabilitation group demonstrated greater improvement than the control group. When the groups were combined, participants reported improvements in FADI and FADI-S scores for the unstable ankle but not the stable ankle.Conclusions:
Our data suggest training the stable ankle may result in improvements in balance and lower extremity function in the unstable ankle. This further supports the existence of a centrally mediated mechanism in the development of postural-control deficits after injury, as well as improved postural control after rehabilitation.Key Words: overflow, crossover training, rehabilitationKey Points
- The rehabilitation group performed better over time on the Foot and Ankle Disability Index Sport and the Star Excursion Balance Test (SEBT) in the anterior, posteromedial, and posterolateral directions, but this was not dependent on ankle.
- Training the stable ankle may provide therapeutic benefit to the unstable ankle.
- Performance on the Balance Error Scoring System did not reflect a therapeutic benefit of the neuromuscular-control training program, but the result should be interpreted with caution.
- Clinicians should consider incorporating rehabilitation of the stable ankle in the overall plan for patients who may not be ready to initiate aspects of rehabilitation on the unstable ankle.